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- W4381597986 abstract "Abstract Recently published work showed that members of the PAQR protein family are activated by cell membrane rigidity and contribute to our ability to eat a wide variety of diets. Cell membranes are primarily composed of phospholipids containing dietarily obtained fatty acids, which poses a challenge to membrane properties because diets can vary greatly in their fatty acid composition and could impart opposite properties to the cellular membranes. In particular, saturated fatty acids (SFAs) can pack tightly and form rigid membranes (like butter at room temperature) while unsaturated fatty acids (UFAs) form more fluid membranes (like vegetable oils). Proteins of the PAQR protein family, characterized by the presence of seven transmembrane domains and a cytosolic N‐terminus, contribute to membrane homeostasis in bacteria, yeasts, and animals. These proteins respond to membrane rigidity by stimulating fatty acid desaturation and incorporation of UFAs into phospholipids and explain the ability of animals to thrive on diets with widely varied fat composition. Also see the video abstract here: https://youtu.be/6ckcvaDdbQg" @default.
- W4381597986 created "2023-06-23" @default.
- W4381597986 creator A5051677373 @default.
- W4381597986 creator A5077239442 @default.
- W4381597986 date "2023-06-22" @default.
- W4381597986 modified "2023-09-26" @default.
- W4381597986 title "PAQR proteins and the evolution of a superpower: Eating all kinds of fats" @default.
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- W4381597986 doi "https://doi.org/10.1002/bies.202300079" @default.
- W4381597986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37345585" @default.
- W4381597986 hasPublicationYear "2023" @default.
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