Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381598047> ?p ?o ?g. }
- W4381598047 endingPage "2439" @default.
- W4381598047 startingPage "2427" @default.
- W4381598047 abstract "Abstract The diagnosis of Brugada syndrome (BrS) requires the presence of a coved (Type 1) ST segment elevation in the right precordial leads of the electrocardiogram (ECG). The dynamic nature of the ECG is well known, and in patients with suspected BrS but non-diagnostic ECG at baseline, a sodium channel blocker test (SCBT) is routinely used to unmask BrS. There is little doubt, however, that in asymptomatic patients, a drug-induced Brugada pattern is associated with a much better prognosis compared to a spontaneous Type 1 ECG. The SCBT is also increasingly used to delineate the arrhythmogenic substrate during ablation studies. In the absence of a “gold standard” for the diagnosis of BrS, sensitivity and specificity of the SCBT remain elusive. By studying patient groups with different underlying diseases, it has become clear that the specificity of the test may not be optimal. This review aims to discuss the pitfalls of the SCBT and provides some directions in whom and when to perform the test. It is concluded that because of the debated specificity and the overall very low risk for future events in asymptomatic individuals, patients should be properly selected and counseled before SCBT is performed and that SCBT should not be performed in asymptomatic patients with a Type 2 Brugada pattern and no family history of BrS or sudden death." @default.
- W4381598047 created "2023-06-23" @default.
- W4381598047 creator A5008259359 @default.
- W4381598047 creator A5026352242 @default.
- W4381598047 creator A5045083789 @default.
- W4381598047 creator A5063961975 @default.
- W4381598047 date "2023-06-22" @default.
- W4381598047 modified "2023-10-04" @default.
- W4381598047 title "Use, misuse, and pitfalls of the drug challenge test in the diagnosis of the Brugada syndrome" @default.
- W4381598047 cites W140924846 @default.
- W4381598047 cites W1483710533 @default.
- W4381598047 cites W1490466277 @default.
- W4381598047 cites W1723287735 @default.
- W4381598047 cites W1890406602 @default.
- W4381598047 cites W1973132958 @default.
- W4381598047 cites W1980537973 @default.
- W4381598047 cites W1980997560 @default.
- W4381598047 cites W1982818774 @default.
- W4381598047 cites W1984153793 @default.
- W4381598047 cites W1989115606 @default.
- W4381598047 cites W1989363116 @default.
- W4381598047 cites W1990826945 @default.
- W4381598047 cites W1995819786 @default.
- W4381598047 cites W2000208388 @default.
- W4381598047 cites W2003377695 @default.
- W4381598047 cites W2005644773 @default.
- W4381598047 cites W2012378267 @default.
- W4381598047 cites W2027136471 @default.
- W4381598047 cites W2030756930 @default.
- W4381598047 cites W2031292103 @default.
- W4381598047 cites W2038083998 @default.
- W4381598047 cites W2045432956 @default.
- W4381598047 cites W2047836551 @default.
- W4381598047 cites W2052627878 @default.
- W4381598047 cites W2053049843 @default.
- W4381598047 cites W2056178523 @default.
- W4381598047 cites W2068643322 @default.
- W4381598047 cites W2078311582 @default.
- W4381598047 cites W2081352325 @default.
- W4381598047 cites W2083421309 @default.
- W4381598047 cites W2083594415 @default.
- W4381598047 cites W2083714051 @default.
- W4381598047 cites W2086406906 @default.
- W4381598047 cites W2089815849 @default.
- W4381598047 cites W2092718460 @default.
- W4381598047 cites W2093823784 @default.
- W4381598047 cites W2095875252 @default.
- W4381598047 cites W2097597642 @default.
- W4381598047 cites W2104001448 @default.
- W4381598047 cites W2107496062 @default.
- W4381598047 cites W2109242434 @default.
- W4381598047 cites W2111107443 @default.
- W4381598047 cites W2111936199 @default.
- W4381598047 cites W2119052397 @default.
- W4381598047 cites W2126935117 @default.
- W4381598047 cites W2128734390 @default.
- W4381598047 cites W2129087585 @default.
- W4381598047 cites W2130073848 @default.
- W4381598047 cites W2133204526 @default.
- W4381598047 cites W2134831745 @default.
- W4381598047 cites W2137615016 @default.
- W4381598047 cites W2137694665 @default.
- W4381598047 cites W2141622694 @default.
- W4381598047 cites W2144237838 @default.
- W4381598047 cites W2146214743 @default.
- W4381598047 cites W2146739569 @default.
- W4381598047 cites W2147325702 @default.
- W4381598047 cites W2147490644 @default.
- W4381598047 cites W2148601586 @default.
- W4381598047 cites W2149984293 @default.
- W4381598047 cites W2151832186 @default.
- W4381598047 cites W2159108018 @default.
- W4381598047 cites W2165819362 @default.
- W4381598047 cites W2167623042 @default.
- W4381598047 cites W2180318936 @default.
- W4381598047 cites W220488953 @default.
- W4381598047 cites W2264508662 @default.
- W4381598047 cites W2279412383 @default.
- W4381598047 cites W2297499338 @default.
- W4381598047 cites W2303889636 @default.
- W4381598047 cites W2306050302 @default.
- W4381598047 cites W2329187849 @default.
- W4381598047 cites W2433313398 @default.
- W4381598047 cites W2464776507 @default.
- W4381598047 cites W2493871576 @default.
- W4381598047 cites W2548415391 @default.
- W4381598047 cites W2586811357 @default.
- W4381598047 cites W2604359798 @default.
- W4381598047 cites W2610316557 @default.
- W4381598047 cites W2613895821 @default.
- W4381598047 cites W2616180695 @default.
- W4381598047 cites W2616249537 @default.
- W4381598047 cites W2626038252 @default.
- W4381598047 cites W2626184202 @default.
- W4381598047 cites W2726661268 @default.
- W4381598047 cites W2728963017 @default.
- W4381598047 cites W2732682916 @default.
- W4381598047 cites W2743523885 @default.