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- W4381617252 startingPage "3271" @default.
- W4381617252 abstract "Caspase-8 is a cysteine-aspartic acid protease that has been identified as an initiator caspase that plays an essential role in the extrinsic apoptotic pathway. Evasion of apoptosis is a hallmark of cancer and Caspase-8 expression is silenced in some tumors, consistent with its central role in apoptosis. However, in the past years, several studies reported an increased expression of Caspase-8 levels in many tumors and consistently identified novel non-canonical non-apoptotic functions of Caspase-8 that overall promote cancer progression and sustain therapy resistance. These reports point to the ability of cancer cells to rewire Caspase-8 function in cancer and raise the question of which are the signaling pathways aberrantly activated in cancer that may contribute to the hijack of Caspase-8 activity. In this regard, tyrosine kinases are among the first oncogenes ever identified and genomic, transcriptomic and proteomic studies indeed show that they represent a class of signaling molecules constitutively activated in most of the tumors. Here, we aim to review and discuss the role of Caspase-8 in cancer and its interplay with Src and other tyrosine kinases." @default.
- W4381617252 created "2023-06-23" @default.
- W4381617252 creator A5035228139 @default.
- W4381617252 creator A5042762556 @default.
- W4381617252 creator A5048656292 @default.
- W4381617252 creator A5057799963 @default.
- W4381617252 creator A5071591004 @default.
- W4381617252 date "2023-06-21" @default.
- W4381617252 modified "2023-10-16" @default.
- W4381617252 title "Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer" @default.
- W4381617252 cites W1493702629 @default.
- W4381617252 cites W1495326470 @default.
- W4381617252 cites W1964581938 @default.
- W4381617252 cites W1965948555 @default.
- W4381617252 cites W1966165467 @default.
- W4381617252 cites W1966861143 @default.
- W4381617252 cites W1968671346 @default.
- W4381617252 cites W1975200051 @default.
- W4381617252 cites W1976111574 @default.
- W4381617252 cites W1976473462 @default.
- W4381617252 cites W1978675599 @default.
- W4381617252 cites W1982166284 @default.
- W4381617252 cites W1986241711 @default.
- W4381617252 cites W1992435071 @default.
- W4381617252 cites W1992831404 @default.
- W4381617252 cites W1996557730 @default.
- W4381617252 cites W1999838288 @default.
- W4381617252 cites W2001478728 @default.
- W4381617252 cites W2002573912 @default.
- W4381617252 cites W2003423830 @default.
- W4381617252 cites W2008610647 @default.
- W4381617252 cites W2013388585 @default.
- W4381617252 cites W2023133242 @default.
- W4381617252 cites W2023583823 @default.
- W4381617252 cites W2024592761 @default.
- W4381617252 cites W2027021865 @default.
- W4381617252 cites W2028893971 @default.
- W4381617252 cites W2057986298 @default.
- W4381617252 cites W2059444339 @default.
- W4381617252 cites W2060669212 @default.
- W4381617252 cites W2066904130 @default.
- W4381617252 cites W2073896185 @default.
- W4381617252 cites W2080377650 @default.
- W4381617252 cites W2080869790 @default.
- W4381617252 cites W2084607024 @default.
- W4381617252 cites W2086925846 @default.
- W4381617252 cites W2091270752 @default.
- W4381617252 cites W2094334993 @default.
- W4381617252 cites W2099606391 @default.
- W4381617252 cites W2100246815 @default.
- W4381617252 cites W2114050989 @default.
- W4381617252 cites W2114843025 @default.
- W4381617252 cites W2117443690 @default.
- W4381617252 cites W2117692326 @default.
- W4381617252 cites W2121842388 @default.
- W4381617252 cites W2129698514 @default.
- W4381617252 cites W2134486128 @default.
- W4381617252 cites W2135201591 @default.
- W4381617252 cites W2136853633 @default.
- W4381617252 cites W2139419679 @default.
- W4381617252 cites W2140364596 @default.
- W4381617252 cites W2141456617 @default.
- W4381617252 cites W2142578085 @default.
- W4381617252 cites W2143178808 @default.
- W4381617252 cites W2149441684 @default.
- W4381617252 cites W2151330389 @default.
- W4381617252 cites W2152145375 @default.
- W4381617252 cites W2157371409 @default.
- W4381617252 cites W2161289668 @default.
- W4381617252 cites W2162399617 @default.
- W4381617252 cites W2169172722 @default.
- W4381617252 cites W2209259861 @default.
- W4381617252 cites W2318205119 @default.
- W4381617252 cites W2341846550 @default.
- W4381617252 cites W2343871152 @default.
- W4381617252 cites W2410981016 @default.
- W4381617252 cites W2462979737 @default.
- W4381617252 cites W2482498495 @default.
- W4381617252 cites W2502738299 @default.
- W4381617252 cites W2571998636 @default.
- W4381617252 cites W2586339216 @default.
- W4381617252 cites W2588177032 @default.
- W4381617252 cites W2600396554 @default.
- W4381617252 cites W2624114007 @default.
- W4381617252 cites W2756470947 @default.
- W4381617252 cites W2790240371 @default.
- W4381617252 cites W2795353688 @default.
- W4381617252 cites W2806340710 @default.
- W4381617252 cites W2902353350 @default.
- W4381617252 cites W2904049988 @default.
- W4381617252 cites W2907885025 @default.
- W4381617252 cites W2938588875 @default.
- W4381617252 cites W2987784277 @default.
- W4381617252 cites W3000877897 @default.
- W4381617252 cites W3011405279 @default.
- W4381617252 cites W3034524078 @default.
- W4381617252 cites W3035581788 @default.
- W4381617252 cites W3092287536 @default.