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- W4381618225 endingPage "10440" @default.
- W4381618225 startingPage "10440" @default.
- W4381618225 abstract "The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its association with Alzheimer's disease (AD) and longevity. This genetic association appears across multiple genes in the APOE locus. Despite the apparent differences between AD and longevity, both conditions share a commonality of aging-related changes in mitochondrial function. This commonality is likely due to accumulative biological effects partly exerted by the APOE locus. In this study, we investigated changes in mitochondrial structure/function-related markers using oxidative stress-induced human cellular models and postmortem brains (PMBs) from individuals with AD and normal controls. Our results reveal a range of expressional alterations, either upregulated or downregulated, in these genes in response to oxidative stress. In contrast, we consistently observed an upregulation of multiple APOE locus genes in all cellular models and AD PMBs. Additionally, the effects of AD status on mitochondrial DNA copy number (mtDNA CN) varied depending on APOE genotype. Our findings imply a potential coregulation of APOE locus genes possibly occurring within the same topologically associating domain (TAD) of the 3D chromosome conformation. The coordinated expression of APOE locus genes could impact mitochondrial function, contributing to the development of AD or longevity. Our study underscores the significant role of the APOE locus in modulating mitochondrial function and provides valuable insights into the underlying mechanisms of AD and aging, emphasizing the importance of this locus in clinical research." @default.
- W4381618225 created "2023-06-23" @default.
- W4381618225 creator A5011618008 @default.
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- W4381618225 creator A5033521964 @default.
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- W4381618225 creator A5088811953 @default.
- W4381618225 date "2023-06-21" @default.
- W4381618225 modified "2023-09-25" @default.
- W4381618225 title "APOE Locus-Associated Mitochondrial Function and Its Implication in Alzheimer’s Disease and Aging" @default.
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- W4381618225 doi "https://doi.org/10.3390/ijms241310440" @default.
- W4381618225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37445616" @default.
- W4381618225 hasPublicationYear "2023" @default.