FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381619762> ?p ?o ?g. }

• W4381619762 abstract "Abstract Study question What is the predicted cumulative live birth rate (CLBR) relative to AMH-level for women undergoing preimplantation genetic testing (PGT) for monogenic disorders and structural rearrangements? Summary answer Anti-müllerian hormone (AMH) and age allow to give an estimate of the CLBR in PGT and becomes poor when AMH is ≤ 2µg/L and age ≥42y. What is known already Ovarian response is an important contributory factor in PGT in order to obtain a sufficient number of embryos for genetic analysis. A proportion of the obtained embryos will be carrier of the disease tested, and another small proportion of the embryos will fail to have a genetic diagnosis hence will not be available for embryo transfer. The number of embryos not suitable for embryo transfer as a result of PGT varies between 25-81% according to the indication for PGT. The combination of female age and AMH are good predictors for CLBR in conventional IVF. Study design, size, duration This is a single-centre retrospective cohort study including 1,522 females undergoing 3,130 PGT cycles over a 6-year period (01/01/2015-31/12/2020) at a university-based referral centre for PGT. The principal outcome measure was CLBR per intention to treat (ITT), and the secondary outcome was live birth rate (LBR) per embryo transfer, in couples undergoing PGT-M and PGT-SR either by polymerase chain reaction (PCR), single nucleotide polymorphism (SNP) array, microarray-based comparative genomic hybridization (aCGH), or next-generation sequencing (NGS). Participants/materials, setting, methods Mean ±SD was applied for continuous outcomes, whereas (relative) frequency was applied for dichotomous outcomes. Multivariable logistic regression analysis was applied with dependent variable being the CLBR or LBR and the independent variables the AMH, female age, BMI, inheritance mode and PGT-technique. Best-fit (Akaike information criterion (AIC)) versus polynomials were analysed. Non-inferiority testing between different technologies was performed. A 3D-prediction mosaic (including AMH, age and CLBR) was created, which can be used for counseling purposes. Main results and the role of chance The mean female age is 32.46 years (SD 4.43), with a mean AMH level of 2.75 µg/L (SD 2.58) and a mean BMI of 24.24 (SD 4.43). Age and AMH significantly affect CLBR irrespective of the inheritance mode or PGT technique used. There is a gradual decline of CLBR from a female age of 25 years onwards reaching a critical threshold of less than 10% CLBR per ITT over the age of 42 with AMH levels ≤2 µg/L. Between cleavage stage biopsy techniques (PCR) and trophectoderm biopsy PGT techniques (SNP array, aCGH, NGS) used there was no significant difference in outcome per ITT, however per embryo transfer there is a significantly higher chance of live birth in SNP array, aCGH and NGS cycles compared to PCR cycles. Limitations, reasons for caution Despite the large sample size, the findings are confined by limited confounder adjustment. Wider implications of the findings In a PGT-program, couples need to be informed on the limited prognosis, if the combination of female age and AMH is unfavourable, in order to allow them to make other reproductive choices. The prediction mosaic produced in this study can be used as an insightful visual tool in counseling PGT-couples. Trial registration number Not applicable" @default.
• W4381619762 created "2023-06-23" @default.
• W4381619762 creator A5003883970 @default.
• W4381619762 creator A5006734538 @default.
• W4381619762 creator A5010207428 @default.
• W4381619762 creator A5012839649 @default.
• W4381619762 creator A5016129566 @default.
• W4381619762 creator A5035032165 @default.
• W4381619762 creator A5035114135 @default.
• W4381619762 creator A5045607127 @default.
• W4381619762 creator A5065086757 @default.
• W4381619762 creator A5067986584 @default.
• W4381619762 creator A5076948411 @default.
• W4381619762 creator A5087730625 @default.
• W4381619762 creator A5092234729 @default.
• W4381619762 date "2023-06-01" @default.
• W4381619762 modified "2023-09-28" @default.
• W4381619762 title "P-709 Predictive heatmap in Preimplantation Genetic Testing for Monogenic disorders (PGT-M) and Structural Rearrangements (PGT-SR)" @default.
• W4381619762 doi "https://doi.org/10.1093/humrep/dead093.1031" @default.
• W4381619762 hasPublicationYear "2023" @default.
• W4381619762 type Work @default.
• W4381619762 citedByCount "0" @default.
• W4381619762 crossrefType "journal-article" @default.
• W4381619762 hasAuthorship W4381619762A5003883970 @default.
• W4381619762 hasAuthorship W4381619762A5006734538 @default.
• W4381619762 hasAuthorship W4381619762A5010207428 @default.
• W4381619762 hasAuthorship W4381619762A5012839649 @default.
• W4381619762 hasAuthorship W4381619762A5016129566 @default.
• W4381619762 hasAuthorship W4381619762A5035032165 @default.
• W4381619762 hasAuthorship W4381619762A5035114135 @default.
• W4381619762 hasAuthorship W4381619762A5045607127 @default.
• W4381619762 hasAuthorship W4381619762A5065086757 @default.
• W4381619762 hasAuthorship W4381619762A5067986584 @default.
• W4381619762 hasAuthorship W4381619762A5076948411 @default.
• W4381619762 hasAuthorship W4381619762A5087730625 @default.
• W4381619762 hasAuthorship W4381619762A5092234729 @default.
• W4381619762 hasBestOaLocation W43816197621 @default.
• W4381619762 hasConcept C126322002 @default.
• W4381619762 hasConcept C131872663 @default.
• W4381619762 hasConcept C160099875 @default.
• W4381619762 hasConcept C167135981 @default.
• W4381619762 hasConcept C196843134 @default.
• W4381619762 hasConcept C2776210078 @default.
• W4381619762 hasConcept C2778279030 @default.
• W4381619762 hasConcept C2778805741 @default.
• W4381619762 hasConcept C2779234561 @default.
• W4381619762 hasConcept C2780673598 @default.
• W4381619762 hasConcept C29456083 @default.
• W4381619762 hasConcept C512716672 @default.
• W4381619762 hasConcept C54355233 @default.
• W4381619762 hasConcept C71924100 @default.
• W4381619762 hasConcept C86803240 @default.
• W4381619762 hasConceptScore W4381619762C126322002 @default.
• W4381619762 hasConceptScore W4381619762C131872663 @default.
• W4381619762 hasConceptScore W4381619762C160099875 @default.
• W4381619762 hasConceptScore W4381619762C167135981 @default.
• W4381619762 hasConceptScore W4381619762C196843134 @default.
• W4381619762 hasConceptScore W4381619762C2776210078 @default.
• W4381619762 hasConceptScore W4381619762C2778279030 @default.
• W4381619762 hasConceptScore W4381619762C2778805741 @default.
• W4381619762 hasConceptScore W4381619762C2779234561 @default.
• W4381619762 hasConceptScore W4381619762C2780673598 @default.
• W4381619762 hasConceptScore W4381619762C29456083 @default.
• W4381619762 hasConceptScore W4381619762C512716672 @default.
• W4381619762 hasConceptScore W4381619762C54355233 @default.
• W4381619762 hasConceptScore W4381619762C71924100 @default.
• W4381619762 hasConceptScore W4381619762C86803240 @default.
• W4381619762 hasIssue "Supplement_1" @default.
• W4381619762 hasLocation W43816197621 @default.
• W4381619762 hasOpenAccess W4381619762 @default.
• W4381619762 hasPrimaryLocation W43816197621 @default.
• W4381619762 hasRelatedWork W1482992277 @default.
• W4381619762 hasRelatedWork W2355835144 @default.
• W4381619762 hasRelatedWork W2908652082 @default.
• W4381619762 hasRelatedWork W3121510571 @default.
• W4381619762 hasRelatedWork W3156285644 @default.
• W4381619762 hasRelatedWork W4220716798 @default.
• W4381619762 hasRelatedWork W4319297546 @default.
• W4381619762 hasRelatedWork W4319601417 @default.
• W4381619762 hasRelatedWork W4386471914 @default.
• W4381619762 hasRelatedWork W3004524109 @default.
• W4381619762 hasVolume "38" @default.
• W4381619762 isParatext "false" @default.
• W4381619762 isRetracted "false" @default.
• W4381619762 workType "article" @default.