FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381619995> ?p ?o ?g. }

• W4381619995 abstract "Abstract Study question Is follicular steroidogenesis impaired in women undergoing random start protocols for fertility preservation? Summary answer The phase of menstrual cycle at initiation of ovarian stimulation does not influence the endocrine microenvironment surrounding oocytes. What is known already Cryopreservation of oocytes is the gold standard for fertility preservation in women with cancer. Random start protocols have been introduced for oocytes cryopreservation in these patients to shorten the duration of ovarian stimulation. However, albeit generally reassuring, available evidence is still insufficient to rule out a sub-optimal cycle outcome of random start protocols. Study design, size, duration The present study was conducted to provide evidence on the validity of random start protocols by exploring the quality of ovarian steroidogenesis. The primary outcome was comparing levels of steroids in the follicular fluid between women initiating the random start protocol in the luteal phase and those initiating in the follicular phase (considered as controls since equivalent to the conventional protocols). We excluded those requiring concomitant letrozole assumption. Participants/materials, setting, methods Seventy-one women with cancer were prospectively recruited during a 24-month period. Thirty-three initiated in luteal phase while 38 in follicular phase. All women were stimulated with recombinant FSH and GnRH antagonists. At the time of oocytes retrieval, follicular fluids were pooled, and a sample was frozen at -80 °C. All samples were assayed concomitantly after thawing, by liquid chromatography tandem mass spectrometry. The concentration of 15 different steroid hormones was determined. Main results and the role of chance Baseline characteristics of the two groups were similar. No differences emerged in anamnestic data and ovarian reserve variables. Cycle outcome did not also differ, the two study groups being similar in terms of total dose of gonadotropins, duration of stimulation, number of developed follicles and number of oocytes retrieved. The median [interquartile range] number of frozen mature oocytes was 9 [5-14] and 10 [5-21] in women who initiated in the luteal and the follicular phase, respectively (p = 0.42). None of the 15 tested steroid hormones differed. Two subgroup secondary analyses were performed to rule out confounders. First, we excluded women who were on estroprogestins at the time of recruitment (leaving 31 women initiating in the follicular phase and 32 in the luteal phase). Levels of steroids in the follicular fluids were still mainly similar. We observed a significant difference only for androstenedione, levels being higher for women initiating stimulation in the follicular phase. Second, we compared women in the early (up to day 5) and late follicular phase (26 and 12 cases, respectively). Levels of steroids in the follicular fluids did not differ except for cortisone, the concentration being higher in the early follicular phase. Limitations, reasons for caution Our study is not randomized, inevitably exposing our results to confounders. Assessment of intraovarian steroidogenesis is an indirect evidence of oocyte quality. Multiple comparisons were done, exposing our findings to type I errors (such as, in our opinion, the differences that emerged in the secondary analyses). Wider implications of the findings Random start protocols have become the standard of care for fertility preservation in women with cancer in the absence of robust evidence. Our data supports the validity of random start protocols in terms of quality of ovarian response since none of the tested hormones differed. Trial registration number Not applicable" @default.
• W4381619995 created "2023-06-23" @default.
• W4381619995 creator A5010157680 @default.
• W4381619995 creator A5015007650 @default.
• W4381619995 creator A5020542860 @default.
• W4381619995 creator A5037804880 @default.
• W4381619995 creator A5053054986 @default.
• W4381619995 creator A5063431711 @default.
• W4381619995 creator A5069350522 @default.
• W4381619995 creator A5073892131 @default.
• W4381619995 date "2023-06-01" @default.
• W4381619995 modified "2023-10-16" @default.
• W4381619995 title "P-419 Oocytes quality in random start protocols for fertility preservation: insights from follicular steroidogenesis." @default.
• W4381619995 doi "https://doi.org/10.1093/humrep/dead093.769" @default.
• W4381619995 hasPublicationYear "2023" @default.
• W4381619995 type Work @default.
• W4381619995 citedByCount "0" @default.
• W4381619995 crossrefType "journal-article" @default.
• W4381619995 hasAuthorship W4381619995A5010157680 @default.
• W4381619995 hasAuthorship W4381619995A5015007650 @default.
• W4381619995 hasAuthorship W4381619995A5020542860 @default.
• W4381619995 hasAuthorship W4381619995A5037804880 @default.
• W4381619995 hasAuthorship W4381619995A5053054986 @default.
• W4381619995 hasAuthorship W4381619995A5063431711 @default.
• W4381619995 hasAuthorship W4381619995A5069350522 @default.
• W4381619995 hasAuthorship W4381619995A5073892131 @default.
• W4381619995 hasBestOaLocation W43816199951 @default.
• W4381619995 hasConcept C126322002 @default.
• W4381619995 hasConcept C143228043 @default.
• W4381619995 hasConcept C16685009 @default.
• W4381619995 hasConcept C187785154 @default.
• W4381619995 hasConcept C2777702977 @default.
• W4381619995 hasConcept C2777904497 @default.
• W4381619995 hasConcept C2779058012 @default.
• W4381619995 hasConcept C2781230225 @default.
• W4381619995 hasConcept C2908647359 @default.
• W4381619995 hasConcept C42407357 @default.
• W4381619995 hasConcept C518429986 @default.
• W4381619995 hasConcept C71315377 @default.
• W4381619995 hasConcept C71924100 @default.
• W4381619995 hasConcept C86803240 @default.
• W4381619995 hasConcept C99454951 @default.
• W4381619995 hasConceptScore W4381619995C126322002 @default.
• W4381619995 hasConceptScore W4381619995C143228043 @default.
• W4381619995 hasConceptScore W4381619995C16685009 @default.
• W4381619995 hasConceptScore W4381619995C187785154 @default.
• W4381619995 hasConceptScore W4381619995C2777702977 @default.
• W4381619995 hasConceptScore W4381619995C2777904497 @default.
• W4381619995 hasConceptScore W4381619995C2779058012 @default.
• W4381619995 hasConceptScore W4381619995C2781230225 @default.
• W4381619995 hasConceptScore W4381619995C2908647359 @default.
• W4381619995 hasConceptScore W4381619995C42407357 @default.
• W4381619995 hasConceptScore W4381619995C518429986 @default.
• W4381619995 hasConceptScore W4381619995C71315377 @default.
• W4381619995 hasConceptScore W4381619995C71924100 @default.
• W4381619995 hasConceptScore W4381619995C86803240 @default.
• W4381619995 hasConceptScore W4381619995C99454951 @default.
• W4381619995 hasIssue "Supplement_1" @default.
• W4381619995 hasLocation W43816199951 @default.
• W4381619995 hasOpenAccess W4381619995 @default.
• W4381619995 hasPrimaryLocation W43816199951 @default.
• W4381619995 hasRelatedWork W2017577003 @default.
• W4381619995 hasRelatedWork W2043899786 @default.
• W4381619995 hasRelatedWork W2067530378 @default.
• W4381619995 hasRelatedWork W2262919345 @default.
• W4381619995 hasRelatedWork W2622422316 @default.
• W4381619995 hasRelatedWork W2899355319 @default.
• W4381619995 hasRelatedWork W2925332910 @default.
• W4381619995 hasRelatedWork W3202490182 @default.
• W4381619995 hasRelatedWork W4294817029 @default.
• W4381619995 hasRelatedWork W4386856184 @default.
• W4381619995 hasVolume "38" @default.
• W4381619995 isParatext "false" @default.
• W4381619995 isRetracted "false" @default.
• W4381619995 workType "article" @default.