FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381619997> ?p ?o ?g. }

• W4381619997 abstract "Abstract Study question Is singleton birth from assisted reproductive technology (ART) associated with imprinting disorders (IDs) independent of parental infertility and other background factors? Summary answer Singletons conceived using intracytoplasmic sperm injection (ICSI) and frozen embryos have higher risks of Beckwith-Wiedemann syndrome (BWS), Prader-Willi syndrome (PWS) and Silver-Russell syndrome (SRS). What is known already Previous studies have suggested elevated risk of IDs in children conceived with ART compared with children conceived with spontaneous conception (SC). It is not clear to what extent the observed associations could be explained by parental infertility and related risk factors. Knowledge on specific ART procedures and their association with IDs is also limited. Study design, size, duration A nationwide register-based cohort study was carried out in which all liveborn singletons in 1997-2017 in Sweden were included with follow-up to 2018. Participants/materials, setting, methods Among 1 998 825 singletons, 60 210 were conceived using ART. The International Classification of Diseases (ICD) version 10 was used to identify three distinct ID groups: PWS/SRS, BWS, and central precocious puberty (CPP). Cox regression, combined with inverse probability treatment weights to account for birth year, parity, pregnancy loss history, parental age and country of origin, was used to compare ART singletons with all SC singletons and those born to couples with known infertility. Main results and the role of chance A total of 1012 children were diagnosed with the IDs of interest (654 PWS/SRS, 255 BWS, and 109 CPP), and 49 of them were conceived through ART. Compared with all SC singletons, higher risk of PWS/SRS and BWS was observed in ART singletons and the weighted hazard ratios (wHRs) were 1.57 [95% CI, 1.09-2.26] and 2.57 [95% CI, 1.60-4.12], respectively. The elevated risks remained when comparison was restricted to SC singletons of couples with known infertility, though the wHR for BWS was somewhat attenuated (1.87, 95% CI: 1.04-3.36). No difference in risk of CPP was observed between singletons conceived with and without ART irrespective of parental infertility. Further subgroup analysis revealed that ICSI in combination with frozen embryo transfer was responsible for the higher risks of PWS/SRS (wHR 6.32, 95% CI: 3.34-11.95) and BWS (wHR 9.04, 95% CI: 4.34-18.82). Limitations, reasons for caution The use of the Swedish ICD-10 did not allow distinction of PWS and SRS. The number of CPP cases in ART singletons was too small (N = 3) to make inference. Wider implications of the findings This study found that ART-conceived singletons, particularly those conceived using ICSI and frozen embryos, had a higher risk of IDs independent of parental infertility. However, the underlying mechanism is not clear, and the role of type and severity of infertility warrants further investigation. Trial registration number not applicable" @default.
• W4381619997 created "2023-06-23" @default.
• W4381619997 creator A5005997456 @default.
• W4381619997 creator A5021233639 @default.
• W4381619997 creator A5048744749 @default.
• W4381619997 creator A5052110402 @default.
• W4381619997 creator A5070160184 @default.
• W4381619997 date "2023-06-01" @default.
• W4381619997 modified "2023-10-03" @default.
• W4381619997 title "O-199 Imprinting disorders in singletons conceived by assisted reproductive technology in Sweden" @default.
• W4381619997 doi "https://doi.org/10.1093/humrep/dead093.240" @default.
• W4381619997 hasPublicationYear "2023" @default.
• W4381619997 type Work @default.
• W4381619997 citedByCount "0" @default.
• W4381619997 crossrefType "journal-article" @default.
• W4381619997 hasAuthorship W4381619997A5005997456 @default.
• W4381619997 hasAuthorship W4381619997A5021233639 @default.
• W4381619997 hasAuthorship W4381619997A5048744749 @default.
• W4381619997 hasAuthorship W4381619997A5052110402 @default.
• W4381619997 hasAuthorship W4381619997A5070160184 @default.
• W4381619997 hasBestOaLocation W43816199971 @default.
• W4381619997 hasConcept C117354338 @default.
• W4381619997 hasConcept C131872663 @default.
• W4381619997 hasConcept C2776659692 @default.
• W4381619997 hasConcept C2777688143 @default.
• W4381619997 hasConcept C2778278907 @default.
• W4381619997 hasConcept C2779234561 @default.
• W4381619997 hasConcept C2780340734 @default.
• W4381619997 hasConcept C29456083 @default.
• W4381619997 hasConcept C2994278967 @default.
• W4381619997 hasConcept C500014431 @default.
• W4381619997 hasConcept C54355233 @default.
• W4381619997 hasConcept C71924100 @default.
• W4381619997 hasConcept C86803240 @default.
• W4381619997 hasConceptScore W4381619997C117354338 @default.
• W4381619997 hasConceptScore W4381619997C131872663 @default.
• W4381619997 hasConceptScore W4381619997C2776659692 @default.
• W4381619997 hasConceptScore W4381619997C2777688143 @default.
• W4381619997 hasConceptScore W4381619997C2778278907 @default.
• W4381619997 hasConceptScore W4381619997C2779234561 @default.
• W4381619997 hasConceptScore W4381619997C2780340734 @default.
• W4381619997 hasConceptScore W4381619997C29456083 @default.
• W4381619997 hasConceptScore W4381619997C2994278967 @default.
• W4381619997 hasConceptScore W4381619997C500014431 @default.
• W4381619997 hasConceptScore W4381619997C54355233 @default.
• W4381619997 hasConceptScore W4381619997C71924100 @default.
• W4381619997 hasConceptScore W4381619997C86803240 @default.
• W4381619997 hasIssue "Supplement_1" @default.
• W4381619997 hasLocation W43816199971 @default.
• W4381619997 hasOpenAccess W4381619997 @default.
• W4381619997 hasPrimaryLocation W43816199971 @default.
• W4381619997 hasRelatedWork W2042807040 @default.
• W4381619997 hasRelatedWork W2062916060 @default.
• W4381619997 hasRelatedWork W2067595320 @default.
• W4381619997 hasRelatedWork W2461485790 @default.
• W4381619997 hasRelatedWork W2526742159 @default.
• W4381619997 hasRelatedWork W4213008302 @default.
• W4381619997 hasRelatedWork W4214941454 @default.
• W4381619997 hasRelatedWork W4250153440 @default.
• W4381619997 hasRelatedWork W4381619997 @default.
• W4381619997 hasRelatedWork W4383116915 @default.
• W4381619997 hasVolume "38" @default.
• W4381619997 isParatext "false" @default.
• W4381619997 isRetracted "false" @default.
• W4381619997 workType "article" @default.