FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381620002> ?p ?o ?g. }

• W4381620002 abstract "Abstract Study question Do infertile women with polycystic ovary syndrome(PCOS) have a higher incidence of chronic endometritis(CE) and need to screened for CE before assisted reproductive technology(ART)? Summary answer Under the diagnosis by CD138 immunohistochemical staining, no significant difference was found in the comparison of CE incidence between PCOS patients and non-PCOS patients. What is known already PCOS is the most common endocrinopathy among women of reproductive age and causes increased risks of embryo implantation failure and pregnancy loss. The chronic low-grade inflammation of the endometrium in PCOS women should not be ignored. CE is a local inflammation of the endometrium and also harms endometrial receptivity. Some specialists suggest that women at high risk of CE (such as endometrial polyps, repeated implantation failure, etc.) should be screened for CE before before ART. However, the risk of CE under the diagnosis by CD138 immunohistochemical staining for endometrial specimen in PCOS women has not been previously evaluated. Study design, size, duration We conducted a retrospective analysis of all infertile patients undergoing their first hysteroscopic operations during 2017-2022 from one tertiary hospital. All patients underwent hysteroscopy in the proliferative phase and endometrial biopsy for immunohistochemistry staining for CD138 was carried out. Cesarean section, intrauterine adhesion, recurrent spontaneous abortion or recurrent implantation failure and other diseases potentially related to chronic endometritis were strictly excluded. The CE incidence between PCOS patients and non-PCOS patients was compared. Participants/materials, setting, methods Endometrial biopsy and immunohistochemistry staining for CD138 was carried out among all patients. Demographic information were recorded. A propensity score matching (PSM) model was used to match the independent variables to balance the influence of confounding factors. Subgroup analysis according to different body mass index were also taken among PCOS patients and non-PCOS patients. Furthermore, a multivariate logistic model was used to explore the risk factors affecting CE incidence. Main results and the role of chance A total of 205 cases were allocated to the PCOS group, while 4021 cases were allocated to the non-PCOS group in the final analysis. After PSM, 197 PCOS patients were matched with 197 patients in the non-PCOS group. Significant differences were only found in the comparisons of PCOS-associated characteristics (P &lt; 0.05) and the other baseline characteristics of the two groups were not significantly different(P &gt; 0.05). No higher CE incidence in infertile women with PCOS was found either in total analysis or after PSM (P = 0.969, OR 1.01, 95% CI: 0.75-1.36; P = 0.385, OR 1.21, 95% CI: 0.75-1.36; respectively). Similar results were discovered in the subgroup of BMI≥28 kg/m2, BMI 24 -28kg/m2, and BMI＜24 kg/m2 (P = 0.301, OR 1.64, 95% CI: 0.64-4.19; P = 0.671, OR 1.13, 95% CI: 0.65-1.95; P = 0.427, OR 0.85, 95% CI: 0.58-1.27; respectively). Interestingly, a rising trend of CE incidence was found with the BMI increased in the PCOS group, even though no significant differences were found (BMI＜24 kg/m2: 28.80%; BMI 24 -28kg/m2: 36.66%; BMI≥28 kg/m2: 45.00%; respectively). Multivariate logistic regression showed that age, infertility duration, infertility type, PCOS, and obesity were not the independent risk factors affecting CE incidence. Limitations, reasons for caution Information bias cannot be ruled out because of the retrospective design of this study. Hence, we used PSM and regression analysis to minimize the impact of confounding variable. Besides, the sample size of patients with PCOS was limited. Therefore, a larger sample size will be used in our future study. Wider implications of the findings We firstly investigate the relationship between PCOS and CE diagnosed by CD138. The current evidence does not support PCOS women should screened for CE before ART. In the future, a larger sample of studies are needed to investigate the relationship between PCOS and CE, especially for obese PCOS patients. Trial registration number not applicable" @default.
• W4381620002 created "2023-06-23" @default.
• W4381620002 creator A5023776809 @default.
• W4381620002 creator A5079448575 @default.
• W4381620002 creator A5089856110 @default.
• W4381620002 creator A5091350741 @default.
• W4381620002 date "2023-06-01" @default.
• W4381620002 modified "2023-09-23" @default.
• W4381620002 title "P-326 No higher incidence of chronic endometritis in infertile women with polycystic ovary syndrome: a propensity score-matched study" @default.
• W4381620002 doi "https://doi.org/10.1093/humrep/dead093.684" @default.
• W4381620002 hasPublicationYear "2023" @default.
• W4381620002 type Work @default.
• W4381620002 citedByCount "0" @default.
• W4381620002 crossrefType "journal-article" @default.
• W4381620002 hasAuthorship W4381620002A5023776809 @default.
• W4381620002 hasAuthorship W4381620002A5079448575 @default.
• W4381620002 hasAuthorship W4381620002A5089856110 @default.
• W4381620002 hasAuthorship W4381620002A5091350741 @default.
• W4381620002 hasBestOaLocation W43816200021 @default.
• W4381620002 hasConcept C120665830 @default.
• W4381620002 hasConcept C121332964 @default.
• W4381620002 hasConcept C126322002 @default.
• W4381620002 hasConcept C131872663 @default.
• W4381620002 hasConcept C134018914 @default.
• W4381620002 hasConcept C2775846227 @default.
• W4381620002 hasConcept C2775934546 @default.
• W4381620002 hasConcept C2775963564 @default.
• W4381620002 hasConcept C2776606343 @default.
• W4381620002 hasConcept C2777391703 @default.
• W4381620002 hasConcept C2777688143 @default.
• W4381620002 hasConcept C2779234561 @default.
• W4381620002 hasConcept C2779742232 @default.
• W4381620002 hasConcept C29456083 @default.
• W4381620002 hasConcept C3018442814 @default.
• W4381620002 hasConcept C54355233 @default.
• W4381620002 hasConcept C555293320 @default.
• W4381620002 hasConcept C61511704 @default.
• W4381620002 hasConcept C71924100 @default.
• W4381620002 hasConcept C86803240 @default.
• W4381620002 hasConceptScore W4381620002C120665830 @default.
• W4381620002 hasConceptScore W4381620002C121332964 @default.
• W4381620002 hasConceptScore W4381620002C126322002 @default.
• W4381620002 hasConceptScore W4381620002C131872663 @default.
• W4381620002 hasConceptScore W4381620002C134018914 @default.
• W4381620002 hasConceptScore W4381620002C2775846227 @default.
• W4381620002 hasConceptScore W4381620002C2775934546 @default.
• W4381620002 hasConceptScore W4381620002C2775963564 @default.
• W4381620002 hasConceptScore W4381620002C2776606343 @default.
• W4381620002 hasConceptScore W4381620002C2777391703 @default.
• W4381620002 hasConceptScore W4381620002C2777688143 @default.
• W4381620002 hasConceptScore W4381620002C2779234561 @default.
• W4381620002 hasConceptScore W4381620002C2779742232 @default.
• W4381620002 hasConceptScore W4381620002C29456083 @default.
• W4381620002 hasConceptScore W4381620002C3018442814 @default.
• W4381620002 hasConceptScore W4381620002C54355233 @default.
• W4381620002 hasConceptScore W4381620002C555293320 @default.
• W4381620002 hasConceptScore W4381620002C61511704 @default.
• W4381620002 hasConceptScore W4381620002C71924100 @default.
• W4381620002 hasConceptScore W4381620002C86803240 @default.
• W4381620002 hasIssue "Supplement_1" @default.
• W4381620002 hasLocation W43816200021 @default.
• W4381620002 hasOpenAccess W4381620002 @default.
• W4381620002 hasPrimaryLocation W43816200021 @default.
• W4381620002 hasRelatedWork W2105068090 @default.
• W4381620002 hasRelatedWork W2116661139 @default.
• W4381620002 hasRelatedWork W2359795764 @default.
• W4381620002 hasRelatedWork W2361087671 @default.
• W4381620002 hasRelatedWork W3196113829 @default.
• W4381620002 hasRelatedWork W4220691288 @default.
• W4381620002 hasRelatedWork W4313238833 @default.
• W4381620002 hasRelatedWork W4381620067 @default.
• W4381620002 hasRelatedWork W2183705678 @default.
• W4381620002 hasRelatedWork W2209158764 @default.
• W4381620002 hasVolume "38" @default.
• W4381620002 isParatext "false" @default.
• W4381620002 isRetracted "false" @default.
• W4381620002 workType "article" @default.