FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381620058> ?p ?o ?g. }

• W4381620058 abstract "Abstract Study question Does semen quality affect preimplantation development and clinical outcomes in ICSI cycles using donor oocytes? Summary answer Poor semen parameters led to altered morphokinetic parameters during preimplantation development but did not compromise blastocyst quality nor clinical outcomes in oocyte donation cycles. What is known already The quality of semen used for in vitro fertilization (IVF) may compromise the kinetics and morphology of developing embryos, ultimately impairing implantation and reducing live birth rates. Such effects are particularly pronounced when testicular or epididymal spermatozoa are used for IVF treatment. However, current studies assessing the impact of poor semen parameters on embryo development and clinical outcomes are often confounded by the use of oocytes from infertile patients. Performing such evaluations in oocyte donation cycles will provide more definitive insights into the role of semen during preimplantation development. Study design, size, duration This retrospective study included 616 embryos from 99 oocyte donation ICSI cycles, performed between February 2018 and July 2019. We compared embryo morphokinetics and clinical outcomes (cumulative pregnancy and live birth rates) across three groups with variable semen parameters. These included donor semen (control group, DD, n = 294), partner sperm obtained by testicular sperm extraction (TESE group, n = 72) and partner semen with altered parameters (including poor concentration, motility and morphology, ALT group, n = 250). Participants/materials, setting, methods We assessed several morphokinetic parameters, including second polar body extrusion (tPB2), pronuclei appearance (PN1a, PN2a), 2-3-4-5-8-cell stages (t2 to t8), start of blastulation (tSB) and blastocyst formation (tB). Kaplan-Meier survival curves were built for each parameter per study group. Survival curves were analysed by Cox regression. Qualitative parameters (even size PN and blastomeres, percent fragmentation, abnormal cleavages, blastocyst grade) were assessed using a Chi-Squared test, while Fisher’s exact test was used to evaluate clinical outcomes. Main results and the role of chance Interestingly, TESE embryos reached several developmental stages faster than the DD group: tPB2 (3.03 vs. 3.08, p &lt; 0.001), PN1a (5.55 vs. 6.19, p &lt; 0.001), PN2a (6.78 vs. 7.36, p &lt; 0.001), tPNf (21.30 vs. 22.20, p = 0.001), t3 (34.02 vs. 35.79, p = 0.016), t4 (35.90 vs. 36.92, p = 0.015), t5 (46.70 vs. 48.07, p = 0.036), t8 (52.48 vs. 55.28, p = 0.049), tSB (85.53 vs. 94.62, p &lt; 0.001) and tB (104.09 vs. 106.60, p = 0.002). ALT embryos were faster in early stages: PN1a (6.63 vs. 6.19, p = 0.005), PN2a (7.84 vs. 7.36, p &lt; 0.001), t5 (48.12 vs. 48.07, p = 0.028), t8 (55.57 vs. 55.28, p = 0.032), but slower in the late stages: tSB (93.71 vs. 94.62, p = 0.001), tB (105.60 vs. 106.60, p = 0.002). Compared to DD, ALT and TESE embryos showed a lower rate of even pronuclei (ALT p = 4.6x10-06; TESE p = 8x10-05) and even blastomeres at the 2-cell (ALT p &lt; 0.001; TESE p = 0.006) and 4-cell stage (ALT p = 0.004; TESE p = 0.005). Moreover, embryos derived from testicular sperm showed significantly higher fragmentation rates at the 8-cell stage (p = 0.005), while no significant differences in the frequency of irregular divisions nor in the number of top-quality blastocysts were detected in ALT and TESE. Importantly, cumulative live birth rates per cycle were similar across all study groups (DD 31/53, ALT 31/51, TESE 8/11; p &gt; 0.05). Limitations, reasons for caution The main limitation resides in the retrospective nature of this study and the limited number of embryos in the TESE group. We also note variability in the testicular biopsy (obstructive and non-obstructive azoospermia) and non-normozoospermic diagnoses (oligozoospermia, teratozoospermia or asthenozoospermia), which may confound the analysis. Wider implications of the findings Although poor semen parameters significantly altered embryo morphokinetics, they did not compromise embryo quality, pregnancy or cumulative live birth rates, resulting in similar clinical outcomes as with double donation. Overall, our findings support the use of autologous sperm with donor oocytes, even in severe cases of male factor infertility. Trial registration number not applicable" @default.
• W4381620058 created "2023-06-23" @default.
• W4381620058 creator A5000733004 @default.
• W4381620058 creator A5023940075 @default.
• W4381620058 creator A5047282667 @default.
• W4381620058 creator A5073355272 @default.
• W4381620058 creator A5081373423 @default.
• W4381620058 creator A5083614468 @default.
• W4381620058 creator A5092234809 @default.
• W4381620058 date "2023-06-01" @default.
• W4381620058 modified "2023-09-23" @default.
• W4381620058 title "O-298 Poor semen parameters alter embryo morphokinetic patterns during preimplantation development but do not compromise clinical outcomes" @default.
• W4381620058 doi "https://doi.org/10.1093/humrep/dead093.362" @default.
• W4381620058 hasPublicationYear "2023" @default.
• W4381620058 type Work @default.
• W4381620058 citedByCount "0" @default.
• W4381620058 crossrefType "journal-article" @default.
• W4381620058 hasAuthorship W4381620058A5000733004 @default.
• W4381620058 hasAuthorship W4381620058A5023940075 @default.
• W4381620058 hasAuthorship W4381620058A5047282667 @default.
• W4381620058 hasAuthorship W4381620058A5073355272 @default.
• W4381620058 hasAuthorship W4381620058A5081373423 @default.
• W4381620058 hasAuthorship W4381620058A5083614468 @default.
• W4381620058 hasAuthorship W4381620058A5092234809 @default.
• W4381620058 hasBestOaLocation W43816200581 @default.
• W4381620058 hasConcept C110758877 @default.
• W4381620058 hasConcept C160099875 @default.
• W4381620058 hasConcept C16685009 @default.
• W4381620058 hasConcept C196843134 @default.
• W4381620058 hasConcept C2776537878 @default.
• W4381620058 hasConcept C2776690073 @default.
• W4381620058 hasConcept C2777589648 @default.
• W4381620058 hasConcept C2777688143 @default.
• W4381620058 hasConcept C2778080409 @default.
• W4381620058 hasConcept C2778093475 @default.
• W4381620058 hasConcept C2778177303 @default.
• W4381620058 hasConcept C2778279030 @default.
• W4381620058 hasConcept C2779234561 @default.
• W4381620058 hasConcept C2781087480 @default.
• W4381620058 hasConcept C28748434 @default.
• W4381620058 hasConcept C29456083 @default.
• W4381620058 hasConcept C512716672 @default.
• W4381620058 hasConcept C54355233 @default.
• W4381620058 hasConcept C71924100 @default.
• W4381620058 hasConcept C86803240 @default.
• W4381620058 hasConcept C87073359 @default.
• W4381620058 hasConceptScore W4381620058C110758877 @default.
• W4381620058 hasConceptScore W4381620058C160099875 @default.
• W4381620058 hasConceptScore W4381620058C16685009 @default.
• W4381620058 hasConceptScore W4381620058C196843134 @default.
• W4381620058 hasConceptScore W4381620058C2776537878 @default.
• W4381620058 hasConceptScore W4381620058C2776690073 @default.
• W4381620058 hasConceptScore W4381620058C2777589648 @default.
• W4381620058 hasConceptScore W4381620058C2777688143 @default.
• W4381620058 hasConceptScore W4381620058C2778080409 @default.
• W4381620058 hasConceptScore W4381620058C2778093475 @default.
• W4381620058 hasConceptScore W4381620058C2778177303 @default.
• W4381620058 hasConceptScore W4381620058C2778279030 @default.
• W4381620058 hasConceptScore W4381620058C2779234561 @default.
• W4381620058 hasConceptScore W4381620058C2781087480 @default.
• W4381620058 hasConceptScore W4381620058C28748434 @default.
• W4381620058 hasConceptScore W4381620058C29456083 @default.
• W4381620058 hasConceptScore W4381620058C512716672 @default.
• W4381620058 hasConceptScore W4381620058C54355233 @default.
• W4381620058 hasConceptScore W4381620058C71924100 @default.
• W4381620058 hasConceptScore W4381620058C86803240 @default.
• W4381620058 hasConceptScore W4381620058C87073359 @default.
• W4381620058 hasIssue "Supplement_1" @default.
• W4381620058 hasLocation W43816200581 @default.
• W4381620058 hasOpenAccess W4381620058 @default.
• W4381620058 hasPrimaryLocation W43816200581 @default.
• W4381620058 hasRelatedWork W1965693865 @default.
• W4381620058 hasRelatedWork W1973007694 @default.
• W4381620058 hasRelatedWork W2110080849 @default.
• W4381620058 hasRelatedWork W2348510606 @default.
• W4381620058 hasRelatedWork W2349296746 @default.
• W4381620058 hasRelatedWork W2364513653 @default.
• W4381620058 hasRelatedWork W2378094771 @default.
• W4381620058 hasRelatedWork W2382159885 @default.
• W4381620058 hasRelatedWork W2400155816 @default.
• W4381620058 hasRelatedWork W4200140020 @default.
• W4381620058 hasVolume "38" @default.
• W4381620058 isParatext "false" @default.
• W4381620058 isRetracted "false" @default.
• W4381620058 workType "article" @default.