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- W4381620220 abstract "Abstract Miscarriages occur in 15% of clinically recognized pregnancies in the general population. Miscarriage has several physical and psychological consequences and might be a risk marker of severe obstetrical complications during the following pregnancies and various long-term pathological conditions, such as venous thromboembolism and cardiovascular diseases. Up to 80% of reproductive losses occur in the first trimester. Miscarriage may be caused by chromosomal abnormalities, antiphospholipid syndrome and other thrombophilia’s, immune and endocrine disorders as well as inflammation. However, in up to 50% of cases, the cause of the miscarriage remains unknown. The microbiome consists of microbes that are both helpful and potentially harmful. Most are symbiotic and some, in smaller numbers, are pathogenic. In a healthy body, pathogenic and symbiotic microbiota coexist without problems. But if there is a disturbance in that balance brought on by infectious illnesses, certain diets, or the prolonged use of antibiotics or other bacteria-destroying medications dysbiosis occurs, stopping these normal interactions. In this presentation the role of the microbiome as well as the virome in recurrent miscarriage will be discussed. Possible mechanism of action will be reviewed and, if available, treatment of a perturbed microbiome will be presented. Trial registration number XXXX" @default.
- W4381620220 created "2023-06-23" @default.
- W4381620220 creator A5018688881 @default.
- W4381620220 date "2023-06-01" @default.
- W4381620220 modified "2023-09-23" @default.
- W4381620220 title "O-227 Viral, bacterial and fungal infections in patients with recurrent miscarriage" @default.
- W4381620220 doi "https://doi.org/10.1093/humrep/dead093.277" @default.
- W4381620220 hasPublicationYear "2023" @default.
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