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• W4381620715 startingPage "216278" @default.
• W4381620715 abstract "Manufacturing chimeric antigen receptor (CAR)-T cells using viral vectors is expensive and time-consuming. In addition, during viral transduction, genes encoding CARs are randomly integrated into the genome, which can cause oncogenesis or produce devastating CAR-tumor cells. Here, using a virus-free and non-transgenic minicircle DNA (mcDNA) vector, we enabled the rapid generation of CD19 CAR-T cells within two days. Furthermore, we demonstrated in vitro and in xenograft models that the antitumor effects of CD19 CAR-T cells produced by mcDNA are as effective as those produced by viral vectors. Finally, we showed that our manufacturing process avoids the production of fatal CAR-tumor cells. Taken together, we have provided a fast, effective, and therapeutically safe method for generating CD19 CAR-T cells for the treatment of leukemia." @default.
• W4381620715 created "2023-06-23" @default.
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• W4381620715 date "2023-08-01" @default.
• W4381620715 modified "2023-09-23" @default.
• W4381620715 title "Rapid generation of CD19 CAR-T cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia" @default.
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• W4381620715 doi "https://doi.org/10.1016/j.canlet.2023.216278" @default.
• W4381620715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37354981" @default.
• W4381620715 hasPublicationYear "2023" @default.
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