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- W4381621145 abstract "Granulosa cell tumors (GCTs) frequently present with elevated levels of estrogen and inhibin. Most diagnoses in the pediatric and adolescent population are juvenile-type GCTs; adult-type GCTs in this population are rare.We describe a 14-year-old female who presented with a large adnexal mass and clinical hyperandrogenism. Laboratory evaluation revealed elevated levels of free and total testosterone, low-normal estradiol, and mildly elevated alpha-fetoprotein (AFP). Other tumor markers, including inhibin, were within normal limits. Intraoperative assessment with unilateral oophorectomy, pathology, and imaging resulted in a diagnosis of a stage IA adult-type GCT.GCTs often result in elevated estrogen and inhibin B levels; however, this case demonstrates that non-classic elevations in testosterone and normal inhibin levels should not eliminate concern for a GCT, particularly in the setting of a large ovarian mass." @default.
- W4381621145 created "2023-06-23" @default.
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- W4381621145 date "2023-06-01" @default.
- W4381621145 modified "2023-09-23" @default.
- W4381621145 title "Atypical Presentation of Granulosa Cell Tumor in an Adolescent: A Case Report" @default.
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- W4381621145 doi "https://doi.org/10.1016/j.jpag.2023.06.007" @default.
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