FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381661856> ?p ?o ?g. }

• W4381661856 abstract "Objectives The low immunogenicity of tumor antigens and unacceptable toxicity of adjuvants has hindered the application and development of tumor vaccines. Hence, we designed a novel anti-tumor vaccine composed of a plant-derived immunostimulant molecular nanoadjuvant (a self-nanoemulsifying system, SND) and the antigen OVA, to reinvigorate the immune response and inhibit tumor progression. Methods In this study, this novel nanoadjuvant with Saponin D (SND) was designed and prepared by low-energy emulsification methods. Several important characteristics of the SND, including morphology, size, polymer dispersity index (PDI), zeta potential, and stability, were estimated, and the cytotoxicity of the SND was evaluated by MTT assay. Additionally, the immune response in terms of antibody titer levels and cellular immunity were evaluated in vivo after immunization with the vaccine, and the preventative and therapeutic effects of this novel vaccine against tumors were estimated. Finally, the antigen release profile was determined by IVIS imaging and by in vivo assay. Results This SND nanoadjuvant had good characteristics including the average particle size of 26.35 ± 0.225 nm, narrow distribution of 0.221 ± 1.76, and stability zeta potential of -12.9 ± 0.83 mV. And also, it had good stability (size, PDI, zeta potential, antigen stability) and low toxicity in vitro and in vivo , and delayed antigen release in vivo . The humoral immune response (IgG, IgG1, IgG2a, and IgG2b) and cellular immune level (cytokines of splenocytes including IFN-γ, IL-4, IL-1β andIL-17A) were both improved greatly after injected immunization at 0, 14, 28 days with the novel nanoadjuvant and antigen OVA. Importantly, this novel nanoadjuvant combined with OVA might lead to the induction of the prevent and treatment efficacy in the E.G7-OVA tumor-bearing mice. Conclusions These results suggested that this novel nanoadjuvant encapsulated natural plant immunostimulant molecular OPD could be a good candidate of tumor vaccine adjuvant for reinvigorating the immune response and powerfully inhibiting tumor growth effect." @default.
• W4381661856 created "2023-06-23" @default.
• W4381661856 creator A5005539479 @default.
• W4381661856 creator A5024385770 @default.
• W4381661856 creator A5031150824 @default.
• W4381661856 creator A5037644867 @default.
• W4381661856 creator A5044238505 @default.
• W4381661856 creator A5045384063 @default.
• W4381661856 creator A5047886846 @default.
• W4381661856 creator A5049225588 @default.
• W4381661856 creator A5053258491 @default.
• W4381661856 creator A5053683203 @default.
• W4381661856 creator A5058609799 @default.
• W4381661856 creator A5060774781 @default.
• W4381661856 creator A5067755910 @default.
• W4381661856 creator A5070792298 @default.
• W4381661856 creator A5072853438 @default.
• W4381661856 date "2023-06-21" @default.
• W4381661856 modified "2023-09-27" @default.
• W4381661856 title "A promising self-nanoemulsifying adjuvant with plant-derived saponin D boosts immune response and exerts an anti-tumor effect" @default.
• W4381661856 cites W1839141223 @default.
• W4381661856 cites W1922412259 @default.
• W4381661856 cites W1938515409 @default.
• W4381661856 cites W1968554125 @default.
• W4381661856 cites W2012268753 @default.
• W4381661856 cites W2032141937 @default.
• W4381661856 cites W2043567210 @default.
• W4381661856 cites W2047902191 @default.
• W4381661856 cites W2072134878 @default.
• W4381661856 cites W2074272681 @default.
• W4381661856 cites W2114070751 @default.
• W4381661856 cites W2144733364 @default.
• W4381661856 cites W2167028666 @default.
• W4381661856 cites W2193982141 @default.
• W4381661856 cites W2368732230 @default.
• W4381661856 cites W2564809671 @default.
• W4381661856 cites W2566775074 @default.
• W4381661856 cites W2884198733 @default.
• W4381661856 cites W2886290895 @default.
• W4381661856 cites W2894921048 @default.
• W4381661856 cites W2894969679 @default.
• W4381661856 cites W2902185751 @default.
• W4381661856 cites W2904297611 @default.
• W4381661856 cites W2966298359 @default.
• W4381661856 cites W2978688118 @default.
• W4381661856 cites W2982632100 @default.
• W4381661856 cites W2999381694 @default.
• W4381661856 cites W3007601922 @default.
• W4381661856 cites W3016559380 @default.
• W4381661856 cites W3025138115 @default.
• W4381661856 cites W3124641163 @default.
• W4381661856 cites W3133971897 @default.
• W4381661856 cites W3216119267 @default.
• W4381661856 cites W4206384730 @default.
• W4381661856 cites W4239658327 @default.
• W4381661856 cites W4282916436 @default.
• W4381661856 cites W4285097347 @default.
• W4381661856 cites W4289528800 @default.
• W4381661856 cites W4297253553 @default.
• W4381661856 cites W4310052224 @default.
• W4381661856 cites W4311092865 @default.
• W4381661856 cites W4319444982 @default.
• W4381661856 doi "https://doi.org/10.3389/fimmu.2023.1154836" @default.
• W4381661856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37415983" @default.
• W4381661856 hasPublicationYear "2023" @default.
• W4381661856 type Work @default.
• W4381661856 citedByCount "0" @default.
• W4381661856 crossrefType "journal-article" @default.
• W4381661856 hasAuthorship W4381661856A5005539479 @default.
• W4381661856 hasAuthorship W4381661856A5024385770 @default.
• W4381661856 hasAuthorship W4381661856A5031150824 @default.
• W4381661856 hasAuthorship W4381661856A5037644867 @default.
• W4381661856 hasAuthorship W4381661856A5044238505 @default.
• W4381661856 hasAuthorship W4381661856A5045384063 @default.
• W4381661856 hasAuthorship W4381661856A5047886846 @default.
• W4381661856 hasAuthorship W4381661856A5049225588 @default.
• W4381661856 hasAuthorship W4381661856A5053258491 @default.
• W4381661856 hasAuthorship W4381661856A5053683203 @default.
• W4381661856 hasAuthorship W4381661856A5058609799 @default.
• W4381661856 hasAuthorship W4381661856A5060774781 @default.
• W4381661856 hasAuthorship W4381661856A5067755910 @default.
• W4381661856 hasAuthorship W4381661856A5070792298 @default.
• W4381661856 hasAuthorship W4381661856A5072853438 @default.
• W4381661856 hasBestOaLocation W43816618561 @default.
• W4381661856 hasConcept C147483822 @default.
• W4381661856 hasConcept C150903083 @default.
• W4381661856 hasConcept C185592680 @default.
• W4381661856 hasConcept C203014093 @default.
• W4381661856 hasConcept C207001950 @default.
• W4381661856 hasConcept C2777701055 @default.
• W4381661856 hasConcept C2777863537 @default.
• W4381661856 hasConcept C2780868878 @default.
• W4381661856 hasConcept C2781264782 @default.
• W4381661856 hasConcept C2909935589 @default.
• W4381661856 hasConcept C2911179620 @default.
• W4381661856 hasConcept C71924100 @default.
• W4381661856 hasConcept C86803240 @default.
• W4381661856 hasConcept C8891405 @default.
• W4381661856 hasConceptScore W4381661856C147483822 @default.
• W4381661856 hasConceptScore W4381661856C150903083 @default.

• next