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• W4381664813 abstract "Endometriosis is one of the most common benign gynecological disorders in reproductive-aged women. The major symptoms are chronic pelvic pain and infertility. Despite its profound impact on women’s health and quality of life, its pathogenesis has not been fully elucidated, it cannot be cured and the long-term use of drugs yields severe side effects and hinders fertility. This review aims to present the advances in pathogenesis and the newly reported lead compounds and drugs managing endometriosis. This paper investigated Genetic changes, estrogen-dependent inflammation induction, progesterone resistance, imbalance in proliferation and apoptosis, angiogenesis, lymphangiogenesis and neurogenesis, and tissue remodeling in its pathogenesis; and explored the pharmacological mechanisms, constitutive relationships, and application prospects of each compound in the text. To date, Resveratrol, Bay1316957, and bardoxifene were effective against lesions and pain in controlled animal studies. In clinical trials, Quinagolide showed no statistical difference with the placebo group; the results of phase II clinical trial of the IL-33 antibody have not been announced yet; clinical trial stage III of vilaprisan was suspended due to drug toxicity. Elagolix was approved for the treatment of endometriosis-related pain, but clinical studies of Elagolix for the pretreatment of patients with endometriosis to before In vitro fertilization treatment have not been fulfilled. The results of a clinical study of Linzagolix in patients with moderate to severe endometriosis-related pain have not been disclosed yet. Letrozole improved the fertility of patients with mild endometriosis. For endometriosis patients with infertility, oral GnRH antagonists and aromatase inhibitors are promising drugs, especially Elagolix and Letrozole." @default.
• W4381664813 created "2023-06-23" @default.
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• W4381664813 date "2023-06-21" @default.
• W4381664813 modified "2023-09-24" @default.
• W4381664813 title "Research advances in drug therapy of endometriosis" @default.
• W4381664813 cites W1482806521 @default.
• W4381664813 cites W1506736207 @default.
• W4381664813 cites W1521813310 @default.
• W4381664813 cites W1546988495 @default.
• W4381664813 cites W1575712003 @default.
• W4381664813 cites W1593694282 @default.
• W4381664813 cites W1949590937 @default.
• W4381664813 cites W1966113688 @default.
• W4381664813 cites W1976877206 @default.
• W4381664813 cites W1978088642 @default.
• W4381664813 cites W1981263394 @default.
• W4381664813 cites W1987147125 @default.
• W4381664813 cites W1994392455 @default.
• W4381664813 cites W2002840726 @default.
• W4381664813 cites W2003129079 @default.
• W4381664813 cites W2007530728 @default.
• W4381664813 cites W2009034762 @default.
• W4381664813 cites W2009718214 @default.
• W4381664813 cites W2010229505 @default.
• W4381664813 cites W2010770199 @default.
• W4381664813 cites W2012650501 @default.
• W4381664813 cites W2017027476 @default.
• W4381664813 cites W2019599115 @default.
• W4381664813 cites W2023298070 @default.
• W4381664813 cites W2028348682 @default.
• W4381664813 cites W2029994287 @default.
• W4381664813 cites W2031756196 @default.
• W4381664813 cites W2038337167 @default.
• W4381664813 cites W2039274017 @default.
• W4381664813 cites W2043862432 @default.
• W4381664813 cites W2045458073 @default.
• W4381664813 cites W2046516822 @default.
• W4381664813 cites W2046759896 @default.
• W4381664813 cites W2048280620 @default.
• W4381664813 cites W2052591056 @default.
• W4381664813 cites W2052734212 @default.
• W4381664813 cites W2054240696 @default.
• W4381664813 cites W2055335169 @default.
• W4381664813 cites W2056251749 @default.
• W4381664813 cites W2056529697 @default.
• W4381664813 cites W2062127602 @default.
• W4381664813 cites W2064322936 @default.
• W4381664813 cites W2066865081 @default.
• W4381664813 cites W2071667212 @default.
• W4381664813 cites W2075026340 @default.
• W4381664813 cites W2076668848 @default.
• W4381664813 cites W2079070934 @default.
• W4381664813 cites W2084795216 @default.
• W4381664813 cites W2085320423 @default.
• W4381664813 cites W2092919766 @default.
• W4381664813 cites W2096579757 @default.
• W4381664813 cites W2097313599 @default.
• W4381664813 cites W2100503022 @default.
• W4381664813 cites W2101766472 @default.
• W4381664813 cites W2102586246 @default.
• W4381664813 cites W2105925637 @default.
• W4381664813 cites W2109525253 @default.
• W4381664813 cites W2110950937 @default.
• W4381664813 cites W2111015948 @default.
• W4381664813 cites W2117304335 @default.
• W4381664813 cites W2120749461 @default.
• W4381664813 cites W2122475546 @default.
• W4381664813 cites W2123895053 @default.
• W4381664813 cites W2124424570 @default.
• W4381664813 cites W2134542679 @default.
• W4381664813 cites W2138001589 @default.
• W4381664813 cites W2141020709 @default.
• W4381664813 cites W2145383112 @default.
• W4381664813 cites W2151903246 @default.
• W4381664813 cites W2152300718 @default.
• W4381664813 cites W2152401059 @default.
• W4381664813 cites W2155206661 @default.
• W4381664813 cites W2155854444 @default.
• W4381664813 cites W2156760929 @default.
• W4381664813 cites W2160761602 @default.
• W4381664813 cites W2163308401 @default.
• W4381664813 cites W2163315477 @default.
• W4381664813 cites W2165943038 @default.
• W4381664813 cites W2168963576 @default.
• W4381664813 cites W2203749559 @default.
• W4381664813 cites W2204545205 @default.
• W4381664813 cites W2236644252 @default.
• W4381664813 cites W2286087213 @default.
• W4381664813 cites W2323264979 @default.

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