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• W4381681686 abstract "Licensed rabies virus vaccines based on whole inactivated virus are effective in humans. However, there is a lack of detailed investigations of the elicited immune response, and whether responses can be improved using novel vaccine platforms. Here we show that two doses of a lipid nanoparticle-formulated unmodified mRNA vaccine encoding the rabies virus glycoprotein (RABV-G) induces higher levels of RABV-G specific plasmablasts and T cells in blood, and plasma cells in the bone marrow compared to two doses of Rabipur in non-human primates. The mRNA vaccine also generates higher RABV-G binding and neutralizing antibody titers than Rabipur, while the degree of somatic hypermutation and clonal diversity of the response are similar for the two vaccines. The higher overall antibody titers induced by the mRNA vaccine translates into improved cross-neutralization of related lyssavirus strains, suggesting that this platform has potential for the development of a broadly protective vaccine against these viruses." @default.
• W4381681686 created "2023-06-23" @default.
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• W4381681686 date "2023-06-22" @default.
• W4381681686 modified "2023-10-09" @default.
• W4381681686 title "Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses" @default.
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• W4381681686 doi "https://doi.org/10.1038/s41467-023-39421-5" @default.
• W4381681686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37349310" @default.
• W4381681686 hasPublicationYear "2023" @default.
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