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• W4381682017 abstract "This article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alteration and systemic inflammation under certain circumstances. The two share common pathophysiology, including enhancement of interleukin-1 neutrophils, activation of the inflammasome, pyroptosis, or NETosis. Moreover, the clinical presentation of the diseases overlaps. However, they are indeed two separate diseases, proven by the differences in the epidemiological and etiological aspects and the pathophysiological processes involved in the development and frequency of some clinical signs. This article highlights potentially exciting areas that have not yet been studied in detail, which could help better understand the development of these diseases. This article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alteration and systemic inflammation under certain circumstances. The two share common pathophysiology, including enhancement of interleukin-1 neutrophils, activation of the inflammasome, pyroptosis, or NETosis. Moreover, the clinical presentation of the diseases overlaps. However, they are indeed two separate diseases, proven by the differences in the epidemiological and etiological aspects and the pathophysiological processes involved in the development and frequency of some clinical signs. This article highlights potentially exciting areas that have not yet been studied in detail, which could help better understand the development of these diseases." @default.
• W4381682017 created "2023-06-23" @default.
• W4381682017 creator A5028187243 @default.
• W4381682017 creator A5088930710 @default.
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• W4381682017 date "2023-06-01" @default.
• W4381682017 modified "2023-10-08" @default.
• W4381682017 title "Pathophysiological and clinical point of view on Kawasaki disease and MIS-C" @default.
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• W4381682017 doi "https://doi.org/10.1016/j.pedneo.2023.05.002" @default.
• W4381682017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453902" @default.
• W4381682017 hasPublicationYear "2023" @default.
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