FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381684823> ?p ?o ?g. }

• W4381684823 endingPage "100654" @default.
• W4381684823 startingPage "100654" @default.
• W4381684823 abstract "PurposeDescribe the clinical outcome of hyperfractionated re-irradiation (HFRT) in patients with recurrent or second primary (SP) head and neck cancer (HNC).MethodsThis prospective observational study included HNC patients eligible for HFRT. Inclusion criteria: age ≥18 years, recurrent or SP HNC, planned re-irradiation and ability to respond to questionnaires. Patients received 1.5 Gy twice daily, five days a week for three (palliative) or four (curative/local control) weeks, total dose 45/60 Gy. Toxicity was scored with CTCAE v3 at baseline, end of treatment, at three, six, 12 and 36 months follow-up. Health-related quality of life (HRQoL) was measured with EORTC QLQ-C30 and EORTC QLQ-H&N35, pre-treatment and eight times until 36 months. In the main outcome (Global quality of life and H&N Pain), a change score of ≥10 was considered clinically significant, and p-values < 0.05 (two-sided) statistically significant. The Kaplan-Meier method was used for survival analyses.ResultsOver four years from 2015, 58 patients were enrolled (37 recurrent and 21 SP). All, but two patients completed treatment as planned. Toxicity (≥grade 3) increased from pre-treatment to end of treatment with improvement in the follow-up period. The mean Global quality of life (QoL) and H&N Pain scores were stable from pre-treatment to three months. Maintained/ improved Global QoL was reported by 60% of patients at three months and 56% of patients at 12 months. For patients with curative, local control and palliative intent, the median survival (range) was 23 (2–53), 10 (1–66) and 14 (3–41) months respectively. Of those alive, the proportion of disease-free patients at 12 and 36 months, were 58% and 48%, respectively.ConclusionMost HNC patients reported maintained HRQoL at three and 12 months after HFRT despite serious toxicity observed in many patients. Long-term survival can be achieved in a limited proportion of the patients." @default.
• W4381684823 created "2023-06-23" @default.
• W4381684823 creator A5003379784 @default.
• W4381684823 creator A5035478857 @default.
• W4381684823 creator A5064341406 @default.
• W4381684823 creator A5070024329 @default.
• W4381684823 creator A5074278239 @default.
• W4381684823 creator A5089704483 @default.
• W4381684823 date "2023-09-01" @default.
• W4381684823 modified "2023-10-18" @default.
• W4381684823 title "Impact of hyperfractionated re-irradiation on quality of life in patients with recurrent or second primary head and neck cancer, a prospective single institutional study" @default.
• W4381684823 cites W127718828 @default.
• W4381684823 cites W1937480701 @default.
• W4381684823 cites W1974833358 @default.
• W4381684823 cites W1976808634 @default.
• W4381684823 cites W1977117542 @default.
• W4381684823 cites W1991732395 @default.
• W4381684823 cites W2000445173 @default.
• W4381684823 cites W2022711355 @default.
• W4381684823 cites W2061014005 @default.
• W4381684823 cites W2070357222 @default.
• W4381684823 cites W2075738043 @default.
• W4381684823 cites W2119046971 @default.
• W4381684823 cites W2121638520 @default.
• W4381684823 cites W2123200562 @default.
• W4381684823 cites W2124654120 @default.
• W4381684823 cites W2128474597 @default.
• W4381684823 cites W2133472045 @default.
• W4381684823 cites W2167569107 @default.
• W4381684823 cites W2603127500 @default.
• W4381684823 cites W2646801317 @default.
• W4381684823 cites W2775150748 @default.
• W4381684823 cites W2802311308 @default.
• W4381684823 cites W2895700371 @default.
• W4381684823 cites W2968682558 @default.
• W4381684823 cites W2986633517 @default.
• W4381684823 cites W3017189588 @default.
• W4381684823 cites W3028053165 @default.
• W4381684823 cites W3091261312 @default.
• W4381684823 cites W3144394701 @default.
• W4381684823 cites W3156494876 @default.
• W4381684823 cites W4213351092 @default.
• W4381684823 cites W4306888971 @default.
• W4381684823 doi "https://doi.org/10.1016/j.ctro.2023.100654" @default.
• W4381684823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37415638" @default.
• W4381684823 hasPublicationYear "2023" @default.
• W4381684823 type Work @default.
• W4381684823 citedByCount "0" @default.
• W4381684823 crossrefType "journal-article" @default.
• W4381684823 hasAuthorship W4381684823A5003379784 @default.
• W4381684823 hasAuthorship W4381684823A5035478857 @default.
• W4381684823 hasAuthorship W4381684823A5064341406 @default.
• W4381684823 hasAuthorship W4381684823A5070024329 @default.
• W4381684823 hasAuthorship W4381684823A5074278239 @default.
• W4381684823 hasAuthorship W4381684823A5089704483 @default.
• W4381684823 hasBestOaLocation W43816848231 @default.
• W4381684823 hasConcept C121608353 @default.
• W4381684823 hasConcept C126322002 @default.
• W4381684823 hasConcept C141071460 @default.
• W4381684823 hasConcept C159110408 @default.
• W4381684823 hasConcept C188816634 @default.
• W4381684823 hasConcept C2776530083 @default.
• W4381684823 hasConcept C2779951463 @default.
• W4381684823 hasConcept C2994186709 @default.
• W4381684823 hasConcept C509974204 @default.
• W4381684823 hasConcept C71924100 @default.
• W4381684823 hasConceptScore W4381684823C121608353 @default.
• W4381684823 hasConceptScore W4381684823C126322002 @default.
• W4381684823 hasConceptScore W4381684823C141071460 @default.
• W4381684823 hasConceptScore W4381684823C159110408 @default.
• W4381684823 hasConceptScore W4381684823C188816634 @default.
• W4381684823 hasConceptScore W4381684823C2776530083 @default.
• W4381684823 hasConceptScore W4381684823C2779951463 @default.
• W4381684823 hasConceptScore W4381684823C2994186709 @default.
• W4381684823 hasConceptScore W4381684823C509974204 @default.
• W4381684823 hasConceptScore W4381684823C71924100 @default.
• W4381684823 hasLocation W43816848231 @default.
• W4381684823 hasLocation W43816848232 @default.
• W4381684823 hasLocation W43816848233 @default.
• W4381684823 hasOpenAccess W4381684823 @default.
• W4381684823 hasPrimaryLocation W43816848231 @default.
• W4381684823 hasRelatedWork W1938654188 @default.
• W4381684823 hasRelatedWork W1997646508 @default.
• W4381684823 hasRelatedWork W1999854806 @default.
• W4381684823 hasRelatedWork W2087822253 @default.
• W4381684823 hasRelatedWork W2102989609 @default.
• W4381684823 hasRelatedWork W2118921797 @default.
• W4381684823 hasRelatedWork W2129187957 @default.
• W4381684823 hasRelatedWork W2154299143 @default.
• W4381684823 hasRelatedWork W3195074806 @default.
• W4381684823 hasRelatedWork W4315465216 @default.
• W4381684823 hasVolume "42" @default.
• W4381684823 isParatext "false" @default.
• W4381684823 isRetracted "false" @default.
• W4381684823 workType "article" @default.