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- W4381714589 abstract "Voltage-gated sodium (Nav) channels constitute a prime target for drug design and discovery, given their implication in various diseases such as epilepsy, migraine and ataxia to name a few. In this regard, performing morphological analysis is a crucial step in comprehensively understanding their biological function and mechanism, as well as in uncovering subtle details of their mechanism that may be elusive to experimental observations. Despite their tremendous therapeutic potential, drug design resources are deficient, particularly in terms of accurate and comprehensive geometric information. This paper presents a geometric dataset of molecular surfaces that are representative of Nav channels in mammals. For each structure we provide three representations and a number of geometric measures, including length, volume and straightness of the recognized channels. To demonstrate the effective use of GEO-Nav, we have tested it on two methods belonging to two different categories of approaches: a sphere-based and a tessellation-based method." @default.
- W4381714589 created "2023-06-24" @default.
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- W4381714589 date "2023-06-21" @default.
- W4381714589 modified "2023-10-14" @default.
- W4381714589 title "GEO-Nav: a geometric dataset of voltage-gated sodium channels" @default.
- W4381714589 doi "https://doi.org/10.48550/arxiv.2306.12348" @default.
- W4381714589 hasPublicationYear "2023" @default.
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