Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381736315> ?p ?o ?g. }
- W4381736315 abstract "The immune system eliminates pathogen intruders such as viruses and bacteria. To recruit immune effectors to virus-infected cells, we conjugated a small molecule, the influenza neuraminidase inhibitor zanamivir, to a nanobody that recognizes the kappa light chains of mouse immunoglobulins. This adduct was designed to achieve half-life extension of zanamivir through complex formation with the much-larger immunoglobulins in the circulation. The zanamivir moiety targets the adduct to virus-infected cells, whereas the anti-kappa component simultaneously delivers polyclonal immunoglobulins of indeterminate specificity and all isotypes. Activation of antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity promoted elimination of influenza neuraminidase-positive cells. A single dose of the conjugate protected mice against influenza A or B viruses and was effective even when given several days after infection with a lethal dose of virus. In the absence of circulating immunoglobulins, we observed no in vivo protection from the adduct. The type of conjugates described here may thus find application for both anti-influenza prophylaxis and therapy." @default.
- W4381736315 created "2023-06-24" @default.
- W4381736315 creator A5043764806 @default.
- W4381736315 creator A5066666004 @default.
- W4381736315 creator A5081514135 @default.
- W4381736315 creator A5085586317 @default.
- W4381736315 date "2023-06-23" @default.
- W4381736315 modified "2023-09-24" @default.
- W4381736315 title "An armed anti-immunoglobulin light chain nanobody protects mice against influenza A and B infections" @default.
- W4381736315 cites W1979122114 @default.
- W4381736315 cites W2002632348 @default.
- W4381736315 cites W2015723482 @default.
- W4381736315 cites W2028849261 @default.
- W4381736315 cites W2030129290 @default.
- W4381736315 cites W2046182783 @default.
- W4381736315 cites W2050205112 @default.
- W4381736315 cites W2053319140 @default.
- W4381736315 cites W2076449193 @default.
- W4381736315 cites W2088080828 @default.
- W4381736315 cites W2095553811 @default.
- W4381736315 cites W2113619184 @default.
- W4381736315 cites W2140489687 @default.
- W4381736315 cites W2140516603 @default.
- W4381736315 cites W2161496722 @default.
- W4381736315 cites W2178825899 @default.
- W4381736315 cites W2223009545 @default.
- W4381736315 cites W2233887337 @default.
- W4381736315 cites W2317056394 @default.
- W4381736315 cites W2325393979 @default.
- W4381736315 cites W2339658610 @default.
- W4381736315 cites W2345882213 @default.
- W4381736315 cites W2405819699 @default.
- W4381736315 cites W2436853049 @default.
- W4381736315 cites W2491163602 @default.
- W4381736315 cites W2575638356 @default.
- W4381736315 cites W2733010680 @default.
- W4381736315 cites W2755028013 @default.
- W4381736315 cites W2766254284 @default.
- W4381736315 cites W2778112560 @default.
- W4381736315 cites W2788587230 @default.
- W4381736315 cites W2788753373 @default.
- W4381736315 cites W2791782653 @default.
- W4381736315 cites W2898721059 @default.
- W4381736315 cites W2949064374 @default.
- W4381736315 cites W296750810 @default.
- W4381736315 cites W3044721763 @default.
- W4381736315 cites W3092014111 @default.
- W4381736315 cites W3134299762 @default.
- W4381736315 cites W4220841727 @default.
- W4381736315 cites W4220879443 @default.
- W4381736315 cites W4226151758 @default.
- W4381736315 cites W4239538531 @default.
- W4381736315 cites W4240323392 @default.
- W4381736315 doi "https://doi.org/10.1126/sciimmunol.adg9459" @default.
- W4381736315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37352373" @default.
- W4381736315 hasPublicationYear "2023" @default.
- W4381736315 type Work @default.
- W4381736315 citedByCount "1" @default.
- W4381736315 countsByYear W43817363152023 @default.
- W4381736315 crossrefType "journal-article" @default.
- W4381736315 hasAuthorship W4381736315A5043764806 @default.
- W4381736315 hasAuthorship W4381736315A5066666004 @default.
- W4381736315 hasAuthorship W4381736315A5081514135 @default.
- W4381736315 hasAuthorship W4381736315A5085586317 @default.
- W4381736315 hasConcept C109316439 @default.
- W4381736315 hasConcept C134164806 @default.
- W4381736315 hasConcept C142724271 @default.
- W4381736315 hasConcept C159047783 @default.
- W4381736315 hasConcept C159654299 @default.
- W4381736315 hasConcept C202751555 @default.
- W4381736315 hasConcept C203014093 @default.
- W4381736315 hasConcept C2522874641 @default.
- W4381736315 hasConcept C2777538117 @default.
- W4381736315 hasConcept C2777546802 @default.
- W4381736315 hasConcept C2779134260 @default.
- W4381736315 hasConcept C2781442963 @default.
- W4381736315 hasConcept C3008058167 @default.
- W4381736315 hasConcept C36394416 @default.
- W4381736315 hasConcept C524204448 @default.
- W4381736315 hasConcept C55493867 @default.
- W4381736315 hasConcept C71924100 @default.
- W4381736315 hasConcept C86803240 @default.
- W4381736315 hasConcept C8891405 @default.
- W4381736315 hasConcept C89423630 @default.
- W4381736315 hasConcept C956191 @default.
- W4381736315 hasConceptScore W4381736315C109316439 @default.
- W4381736315 hasConceptScore W4381736315C134164806 @default.
- W4381736315 hasConceptScore W4381736315C142724271 @default.
- W4381736315 hasConceptScore W4381736315C159047783 @default.
- W4381736315 hasConceptScore W4381736315C159654299 @default.
- W4381736315 hasConceptScore W4381736315C202751555 @default.
- W4381736315 hasConceptScore W4381736315C203014093 @default.
- W4381736315 hasConceptScore W4381736315C2522874641 @default.
- W4381736315 hasConceptScore W4381736315C2777538117 @default.
- W4381736315 hasConceptScore W4381736315C2777546802 @default.
- W4381736315 hasConceptScore W4381736315C2779134260 @default.
- W4381736315 hasConceptScore W4381736315C2781442963 @default.
- W4381736315 hasConceptScore W4381736315C3008058167 @default.
- W4381736315 hasConceptScore W4381736315C36394416 @default.
- W4381736315 hasConceptScore W4381736315C524204448 @default.