Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381736500> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4381736500 endingPage "3013" @default.
- W4381736500 startingPage "3003" @default.
- W4381736500 abstract "Background/Aim: Dendritic cells (DCs) are difficult to evaluate in lung regional lymph nodes because of region-specific structures, such as abundant trabeculae connecting the medullary and subcapsular sinuses, the latter of which contains few anthracotic macrophages. Therefore, DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DCsign)-positive DCs and CD68-positive macrophages are unlikely to show a typical distribution. The present study therefore explored quantitative factors connecting the nodal DC morphology to the patient outcome. Materials and Methods: Lymph nodes from 34 non-small-cell lung cancer patients who underwent complete resection were used for immunohistochemical assessments of DCsign and CD68 and terminal deoxynucleotidyl transferase dUTP nick-end labeling. Preoperative patient blood samples were used for the quantitative evaluation of monocytes. Results: The nodal DCs showed a complementary distribution with macrophages, thus few DCs were seen in clusters of macrophages. DCs often presented as a mesh-like rosette that was solitary or connected to a DC cluster. DCs disappeared, and some macrophages were apoptotic when surrounded by cancer cells that have metastasized to lymph nodes. The proportional area of a DC cluster was significantly associated with the histological differentiation of cancer (p=0.013), with a higher ratio tending to lead to a better overall survival (p=0.059), and significantly so in adenocarcinoma (p=0.007). The rosette number was significantly correlated with the smoking index and blood monocyte number (p=0.013 and p=0.005, respectively). Conclusion: The nodal DC morphology appears useful as a prognostic factor and may lead to a new phase of clinicopathological studies of solid cancers." @default.
- W4381736500 created "2023-06-24" @default.
- W4381736500 creator A5001047459 @default.
- W4381736500 creator A5012082251 @default.
- W4381736500 creator A5017814647 @default.
- W4381736500 creator A5025451148 @default.
- W4381736500 creator A5026891445 @default.
- W4381736500 creator A5033696516 @default.
- W4381736500 creator A5050353361 @default.
- W4381736500 creator A5059253184 @default.
- W4381736500 creator A5072184987 @default.
- W4381736500 creator A5083469095 @default.
- W4381736500 creator A5087669950 @default.
- W4381736500 creator A5091072914 @default.
- W4381736500 date "2023-06-23" @default.
- W4381736500 modified "2023-10-18" @default.
- W4381736500 title "Clinical Significance of Nodal DCsign Expression in Non-small-cell Lung Cancer Patients" @default.
- W4381736500 doi "https://doi.org/10.21873/anticanres.16471" @default.
- W4381736500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37351958" @default.
- W4381736500 hasPublicationYear "2023" @default.
- W4381736500 type Work @default.
- W4381736500 citedByCount "0" @default.
- W4381736500 crossrefType "journal-article" @default.
- W4381736500 hasAuthorship W4381736500A5001047459 @default.
- W4381736500 hasAuthorship W4381736500A5012082251 @default.
- W4381736500 hasAuthorship W4381736500A5017814647 @default.
- W4381736500 hasAuthorship W4381736500A5025451148 @default.
- W4381736500 hasAuthorship W4381736500A5026891445 @default.
- W4381736500 hasAuthorship W4381736500A5033696516 @default.
- W4381736500 hasAuthorship W4381736500A5050353361 @default.
- W4381736500 hasAuthorship W4381736500A5059253184 @default.
- W4381736500 hasAuthorship W4381736500A5072184987 @default.
- W4381736500 hasAuthorship W4381736500A5083469095 @default.
- W4381736500 hasAuthorship W4381736500A5087669950 @default.
- W4381736500 hasAuthorship W4381736500A5091072914 @default.
- W4381736500 hasConcept C121608353 @default.
- W4381736500 hasConcept C126322002 @default.
- W4381736500 hasConcept C142724271 @default.
- W4381736500 hasConcept C147483822 @default.
- W4381736500 hasConcept C203014093 @default.
- W4381736500 hasConcept C204232928 @default.
- W4381736500 hasConcept C2776256026 @default.
- W4381736500 hasConcept C2776460901 @default.
- W4381736500 hasConcept C2778170410 @default.
- W4381736500 hasConcept C2779720271 @default.
- W4381736500 hasConcept C2780849966 @default.
- W4381736500 hasConcept C2781182431 @default.
- W4381736500 hasConcept C2781184567 @default.
- W4381736500 hasConcept C71924100 @default.
- W4381736500 hasConceptScore W4381736500C121608353 @default.
- W4381736500 hasConceptScore W4381736500C126322002 @default.
- W4381736500 hasConceptScore W4381736500C142724271 @default.
- W4381736500 hasConceptScore W4381736500C147483822 @default.
- W4381736500 hasConceptScore W4381736500C203014093 @default.
- W4381736500 hasConceptScore W4381736500C204232928 @default.
- W4381736500 hasConceptScore W4381736500C2776256026 @default.
- W4381736500 hasConceptScore W4381736500C2776460901 @default.
- W4381736500 hasConceptScore W4381736500C2778170410 @default.
- W4381736500 hasConceptScore W4381736500C2779720271 @default.
- W4381736500 hasConceptScore W4381736500C2780849966 @default.
- W4381736500 hasConceptScore W4381736500C2781182431 @default.
- W4381736500 hasConceptScore W4381736500C2781184567 @default.
- W4381736500 hasConceptScore W4381736500C71924100 @default.
- W4381736500 hasIssue "7" @default.
- W4381736500 hasLocation W43817365001 @default.
- W4381736500 hasLocation W43817365002 @default.
- W4381736500 hasOpenAccess W4381736500 @default.
- W4381736500 hasPrimaryLocation W43817365001 @default.
- W4381736500 hasRelatedWork W2010703875 @default.
- W4381736500 hasRelatedWork W2055408311 @default.
- W4381736500 hasRelatedWork W2067190873 @default.
- W4381736500 hasRelatedWork W2079965339 @default.
- W4381736500 hasRelatedWork W2355691812 @default.
- W4381736500 hasRelatedWork W2357370115 @default.
- W4381736500 hasRelatedWork W2363326412 @default.
- W4381736500 hasRelatedWork W2386518922 @default.
- W4381736500 hasRelatedWork W2411770056 @default.
- W4381736500 hasRelatedWork W4301944521 @default.
- W4381736500 hasVolume "43" @default.
- W4381736500 isParatext "false" @default.
- W4381736500 isRetracted "false" @default.
- W4381736500 workType "article" @default.