Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381738619> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4381738619 endingPage "3212" @default.
- W4381738619 startingPage "3203" @default.
- W4381738619 abstract "Background/Aim: Ramucirumab has been approved for the management of hepatocellular carcinoma (HCC) after progression on sorafenib; however, the data on ramucirumab in heavily pretreated HCC are limited. This study aimed to investigate the real-world efficacy and safety of ramucirumab in patients with heavily pretreated advanced HCC. Patients and Methods: Patients with advanced HCC who received intravenous ramucirumab as second-line and later therapy were retrospectively reviewed. Kaplan–Meier method was used to analyze progression-free survival (PFS) and overall survival (OS). Additionally, prognostic factors were estimated using hazard ratios with 95% confidence intervals. Results: In total, 31 patients with advanced HCC who received ramucirumab were enrolled, including 11 patients with second-line treatment and 20 with third-line and later-line treatment. The objective response rate was 3.2% with a disease control rate (DCR) of 45.2%, and the DCR of ramucirumab between the second-line group and the third-line and later-line groups did not differ. The median PFS and OS were 2.1 months and 6.7 months, respectively, in the whole population. In the multivariate analyses, alpha-fetoprotein <1,000 ng/ml was an independent prognostic factor for better PFS and OS. All adverse events were classified as grade 1-2 without grade 3-4 toxicities or drug-related mortality. Additionally, 51.6% of patients received subsequent therapy after progression on ramucirumab. Conclusion: The results of our study show the efficacy and safety of ramucirumab in patients with heavily pretreated HCC in real-world practice." @default.
- W4381738619 created "2023-06-24" @default.
- W4381738619 creator A5001467169 @default.
- W4381738619 creator A5020836140 @default.
- W4381738619 creator A5024318722 @default.
- W4381738619 creator A5030906835 @default.
- W4381738619 creator A5044171856 @default.
- W4381738619 creator A5080384965 @default.
- W4381738619 creator A5082950787 @default.
- W4381738619 date "2023-06-23" @default.
- W4381738619 modified "2023-09-27" @default.
- W4381738619 title "The Efficacy and Safety of Ramucirumab in Heavily Pretreated Advanced Hepatocellular Carcinoma" @default.
- W4381738619 doi "https://doi.org/10.21873/anticanres.16494" @default.
- W4381738619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37351980" @default.
- W4381738619 hasPublicationYear "2023" @default.
- W4381738619 type Work @default.
- W4381738619 citedByCount "0" @default.
- W4381738619 crossrefType "journal-article" @default.
- W4381738619 hasAuthorship W4381738619A5001467169 @default.
- W4381738619 hasAuthorship W4381738619A5020836140 @default.
- W4381738619 hasAuthorship W4381738619A5024318722 @default.
- W4381738619 hasAuthorship W4381738619A5030906835 @default.
- W4381738619 hasAuthorship W4381738619A5044171856 @default.
- W4381738619 hasAuthorship W4381738619A5080384965 @default.
- W4381738619 hasAuthorship W4381738619A5082950787 @default.
- W4381738619 hasConcept C126322002 @default.
- W4381738619 hasConcept C143998085 @default.
- W4381738619 hasConcept C197934379 @default.
- W4381738619 hasConcept C207103383 @default.
- W4381738619 hasConcept C2776694085 @default.
- W4381738619 hasConcept C2778019345 @default.
- W4381738619 hasConcept C2778695046 @default.
- W4381738619 hasConcept C2779551604 @default.
- W4381738619 hasConcept C44249647 @default.
- W4381738619 hasConcept C71924100 @default.
- W4381738619 hasConcept C90924648 @default.
- W4381738619 hasConceptScore W4381738619C126322002 @default.
- W4381738619 hasConceptScore W4381738619C143998085 @default.
- W4381738619 hasConceptScore W4381738619C197934379 @default.
- W4381738619 hasConceptScore W4381738619C207103383 @default.
- W4381738619 hasConceptScore W4381738619C2776694085 @default.
- W4381738619 hasConceptScore W4381738619C2778019345 @default.
- W4381738619 hasConceptScore W4381738619C2778695046 @default.
- W4381738619 hasConceptScore W4381738619C2779551604 @default.
- W4381738619 hasConceptScore W4381738619C44249647 @default.
- W4381738619 hasConceptScore W4381738619C71924100 @default.
- W4381738619 hasConceptScore W4381738619C90924648 @default.
- W4381738619 hasIssue "7" @default.
- W4381738619 hasLocation W43817386191 @default.
- W4381738619 hasLocation W43817386192 @default.
- W4381738619 hasOpenAccess W4381738619 @default.
- W4381738619 hasPrimaryLocation W43817386191 @default.
- W4381738619 hasRelatedWork W1990960836 @default.
- W4381738619 hasRelatedWork W2378315152 @default.
- W4381738619 hasRelatedWork W2381257096 @default.
- W4381738619 hasRelatedWork W2754556903 @default.
- W4381738619 hasRelatedWork W2934884265 @default.
- W4381738619 hasRelatedWork W2957827266 @default.
- W4381738619 hasRelatedWork W2996489733 @default.
- W4381738619 hasRelatedWork W3149838050 @default.
- W4381738619 hasRelatedWork W3152395983 @default.
- W4381738619 hasRelatedWork W3204411353 @default.
- W4381738619 hasVolume "43" @default.
- W4381738619 isParatext "false" @default.
- W4381738619 isRetracted "false" @default.
- W4381738619 workType "article" @default.