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- W4381738791 abstract "Background. Patients with Bipolar Disorder (BD) are frequently exposed to traumatic events which worsen disease course, but this study is the first multicentre randomised controlled trial to test the efficacy of a trauma-focused adjunctive psychotherapy in reducing BD affective relapse rates.Methods. This multicentre RCT included 77 patients with BD and current trauma-related symptoms. Participants were randomised to either 20 sessions of trauma-focused Eye Movement Desensitization and Reprocessing (EMDR) therapy for BD, or 20 sessions of supportive therapy (ST). The primary outcome was relapse rates over 24-months, and secondary outcomes were improvements in affective and trauma symptoms, general functioning, and cognitive impairment, assessed at baseline, post-treatment, and at 12- and 24-month follow-up. The trial was registered prior to starting enrolment in clinical trials (NCT02634372) and carried out in accordance with CONSORT guidelines.Results. There was no significant difference between treatment conditions in terms of relapse rates either with or without hospitalization. EMDR was significantly superior to ST at the 12-month follow up in terms of reducing depressive symptoms (p=0.0006, d=0.969), manic symptoms (p=0.027, d=0.513), and improving functioning (p=0.038, d=0.486). There was no significant difference in dropout between treatment arms.Conclusions. Although the primary efficacy criterion was not met in the current study, trauma-focused EMDR led to the reduction of affective symptoms and improvement of functioning, with benefits maintained at six months following the end of treatment. Importantly, focusing on traumatic events did increase relapses or dropouts, suggesting psychological trauma can safely be addressed in a BD population using this protocol." @default.
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- W4381738791 date "2023-06-22" @default.
- W4381738791 modified "2023-10-18" @default.
- W4381738791 title "EMDR therapy vs. Supportive Therapy as adjunctive treatment in trauma-exposed bipolar patients: a randomized controlled trial." @default.
- W4381738791 doi "https://doi.org/10.31234/osf.io/s5hrf" @default.
- W4381738791 hasPublicationYear "2023" @default.
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