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- W4381793896 abstract "Abstract Data on the effects of heterologous antilymphocyte sera (ALS) on the cellular kinetics of the immune response of mice to sheep erythrocytes were obtained using the hemolytic plaque technique as an assay system. Mice given progressively increasing amounts of ALS had exponential decreases in the number of splenic plaque-forming cells (PFC) 4 days following primary immunization. There was a linear relationship between the logarithms of the numbers of PFC and the dilutions of ALS used. Combined treatment with ALS and anti-sheep cell serum produced complete suppression of splenic PFC against sheep erythrocytes, whereas treatment with either serum alone did not. Since the mechanism of action of anti-sheep cell antibody is believed to involve the inactivation of immunogenic antigen at stages later than induction, it acts synergistically with ALS. The inability of ALS to suppress “background” PFC further supports the view that its primary effects are on inductive events of the immune response. Increasing the antigenic stimulus only slightly enhanced the immune response of ALS-treated mice. Infusion of ALS-treated mice with 5 × 107 syngeneic spleen or thymus cells resulted in an 8- to 10-fold increase in the number of splenic PFC. Removal of an adherent cell population markedly reduced the ability of these infused cells to restore immunocompetence. These data support the view that ALS has a preferential effect on antigen-sensitive, thymus-derived cells." @default.
- W4381793896 created "2023-06-24" @default.
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- W4381793896 date "1969-10-01" @default.
- W4381793896 modified "2023-10-10" @default.
- W4381793896 title "Studies on Heterologous Antilymphocyte and Antithymocyte Sera" @default.
- W4381793896 doi "https://doi.org/10.4049/jimmunol.103.4.648" @default.
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