Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381802010> ?p ?o ?g. }
- W4381802010 abstract "Stringent control of type I interferon (IFN-I) signaling is critical to potent innate immune responses against viral infection, yet the underlying molecular mechanisms are still elusive. Here, we found that Van Gogh-like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator to suppress IFN-I signaling during vesicular stomatitis virus (VSV) infection. Mechanistically, VANGL2 interacted with TBK1 and promoted the selective autophagic degradation of TBK1 via K48-linked polyubiquitination at Lys372 by the E3 ligase TRIP, which serves as a recognition signal for the cargo receptor OPTN. Furthermore, myeloid-specific deletion of VANGL2 in mice showed enhanced IFN-I production against VSV infection and improved survival. In general, these findings revealed a negative feedback loop of IFN-I signaling through the VANGL2-TRIP-TBK1-OPTN axis and highlighted the cross-talk between IFN-I and autophagy in preventing viral infection. VANGL2 could be a potential clinical therapeutic target for viral infectious diseases, including COVID-19." @default.
- W4381802010 created "2023-06-24" @default.
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- W4381802010 date "2023-06-23" @default.
- W4381802010 modified "2023-09-25" @default.
- W4381802010 title "VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation" @default.
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- W4381802010 doi "https://doi.org/10.1126/sciadv.adg2339" @default.
- W4381802010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37352355" @default.
- W4381802010 hasPublicationYear "2023" @default.
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