Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381802247> ?p ?o ?g. }
- W4381802247 endingPage "10" @default.
- W4381802247 startingPage "1" @default.
- W4381802247 abstract "Background. Both high-fat diet (HFD) and 4-nonylphenol (4-NP) could affect fat formation in adipose tissue individually. We investigated whether HFD promote abnormal adipose tissue formation caused by early exposure to 4-NP in life and preliminarily explore the possible mechanisms involved. Methods. The first-generation rats were treated with HFD on postnatal day after pregnant rats exposure to 5 ug/kg/day 4-NP. Then, the second generation rats started to only receive normal diet without 4-NP or HFD. We analyzed organ coefficient and histopathology of fat tissues, biochemical index, and gene level involved in lipid metabolism in female offspring rats. Results. HFD and 4-NP interaction synergistically increased birth weight, body weight, and organ coefficients of adipose tissue in offspring female rats. HFD accelerately aggravated abnormal lipid metabolism and increased the adipocyte mean areas around the uterus of the offspring female rats induced by prenatal exposure to 4-NP. HFD also facilitate the regulation of gene expression involved lipid metabolism in offspring female rats induced by perinatal exposure to 4-NP, even passed on to the second generation of female rats. Moreover, HFD and 4-NP interaction synergistically declined the gene and protein expression of estrogen receptor (ER) in the adipose tissue of second-generation female rats. Conclusion. HFD and 4-NP synergistically regulate the expression of lipid metabolism genes in adipose tissue of F2 female rats and promote adipose tissue generation, leading to obesity in offspring rats, which is closely related to low expression of ER. Therefore, ER genes and proteins may be involved in the synergistic effect of HFD and 4-NP." @default.
- W4381802247 created "2023-06-24" @default.
- W4381802247 creator A5000995491 @default.
- W4381802247 creator A5017243775 @default.
- W4381802247 creator A5041105225 @default.
- W4381802247 creator A5048718607 @default.
- W4381802247 creator A5051072389 @default.
- W4381802247 creator A5058691896 @default.
- W4381802247 creator A5062371490 @default.
- W4381802247 creator A5076442862 @default.
- W4381802247 creator A5080183359 @default.
- W4381802247 creator A5085654199 @default.
- W4381802247 creator A5089840020 @default.
- W4381802247 date "2023-06-23" @default.
- W4381802247 modified "2023-10-17" @default.
- W4381802247 title "High-Fat Diet Promotes Adipogenesis in Offspring Female Rats Induced by Perinatal Exposure to 4-Nonylphenol" @default.
- W4381802247 cites W1832924936 @default.
- W4381802247 cites W1974867893 @default.
- W4381802247 cites W2014418023 @default.
- W4381802247 cites W2060216215 @default.
- W4381802247 cites W2062736591 @default.
- W4381802247 cites W2063536020 @default.
- W4381802247 cites W2075085475 @default.
- W4381802247 cites W2075732399 @default.
- W4381802247 cites W2091934134 @default.
- W4381802247 cites W2130597092 @default.
- W4381802247 cites W2152688545 @default.
- W4381802247 cites W2222832814 @default.
- W4381802247 cites W2417815475 @default.
- W4381802247 cites W2466677251 @default.
- W4381802247 cites W2553727184 @default.
- W4381802247 cites W2751277785 @default.
- W4381802247 cites W2766393670 @default.
- W4381802247 cites W2774549531 @default.
- W4381802247 cites W2793066282 @default.
- W4381802247 cites W2883293309 @default.
- W4381802247 cites W2911115446 @default.
- W4381802247 cites W2969781866 @default.
- W4381802247 cites W2971953119 @default.
- W4381802247 cites W2975171312 @default.
- W4381802247 cites W2991382489 @default.
- W4381802247 cites W3023490346 @default.
- W4381802247 cites W3080877752 @default.
- W4381802247 cites W3083805463 @default.
- W4381802247 cites W3104502335 @default.
- W4381802247 cites W3139037035 @default.
- W4381802247 cites W3150863389 @default.
- W4381802247 cites W3158355150 @default.
- W4381802247 cites W3161404038 @default.
- W4381802247 cites W3165057978 @default.
- W4381802247 cites W3199231291 @default.
- W4381802247 cites W3204032047 @default.
- W4381802247 cites W4205283001 @default.
- W4381802247 cites W4221098109 @default.
- W4381802247 cites W4282930530 @default.
- W4381802247 doi "https://doi.org/10.1155/2023/6540585" @default.
- W4381802247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37398946" @default.
- W4381802247 hasPublicationYear "2023" @default.
- W4381802247 type Work @default.
- W4381802247 citedByCount "0" @default.
- W4381802247 crossrefType "journal-article" @default.
- W4381802247 hasAuthorship W4381802247A5000995491 @default.
- W4381802247 hasAuthorship W4381802247A5017243775 @default.
- W4381802247 hasAuthorship W4381802247A5041105225 @default.
- W4381802247 hasAuthorship W4381802247A5048718607 @default.
- W4381802247 hasAuthorship W4381802247A5051072389 @default.
- W4381802247 hasAuthorship W4381802247A5058691896 @default.
- W4381802247 hasAuthorship W4381802247A5062371490 @default.
- W4381802247 hasAuthorship W4381802247A5076442862 @default.
- W4381802247 hasAuthorship W4381802247A5080183359 @default.
- W4381802247 hasAuthorship W4381802247A5085654199 @default.
- W4381802247 hasAuthorship W4381802247A5089840020 @default.
- W4381802247 hasBestOaLocation W43818022471 @default.
- W4381802247 hasConcept C112672928 @default.
- W4381802247 hasConcept C121608353 @default.
- W4381802247 hasConcept C122927707 @default.
- W4381802247 hasConcept C126322002 @default.
- W4381802247 hasConcept C134018914 @default.
- W4381802247 hasConcept C171089720 @default.
- W4381802247 hasConcept C2776175234 @default.
- W4381802247 hasConcept C2779234561 @default.
- W4381802247 hasConcept C4733338 @default.
- W4381802247 hasConcept C530470458 @default.
- W4381802247 hasConcept C54355233 @default.
- W4381802247 hasConcept C71924100 @default.
- W4381802247 hasConcept C84606932 @default.
- W4381802247 hasConcept C86803240 @default.
- W4381802247 hasConceptScore W4381802247C112672928 @default.
- W4381802247 hasConceptScore W4381802247C121608353 @default.
- W4381802247 hasConceptScore W4381802247C122927707 @default.
- W4381802247 hasConceptScore W4381802247C126322002 @default.
- W4381802247 hasConceptScore W4381802247C134018914 @default.
- W4381802247 hasConceptScore W4381802247C171089720 @default.
- W4381802247 hasConceptScore W4381802247C2776175234 @default.
- W4381802247 hasConceptScore W4381802247C2779234561 @default.
- W4381802247 hasConceptScore W4381802247C4733338 @default.
- W4381802247 hasConceptScore W4381802247C530470458 @default.
- W4381802247 hasConceptScore W4381802247C54355233 @default.