Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381805120> ?p ?o ?g. }
- W4381805120 endingPage "2835" @default.
- W4381805120 startingPage "2835" @default.
- W4381805120 abstract "Diabetes is associated with an imbalance between oxidants and antioxidants, leading to oxidative stress. This imbalance contributes to the development and progression of diabetic complications. Similarly, renal and liver diseases are characterised by oxidative stress, where an excess of oxidants overwhelms the antioxidant defense mechanisms, causing tissue damage and dysfunction. Restoring the oxidant-antioxidant balance is essential for mitigating oxidative stress-related damage under these conditions. In this current study, the efficacy of stingless bee honey (SBH) and its phenolic-rich extract (PRE) in controlling the oxidant-antioxidant balance in high-fat diet- and streptozotocin/nicotinamide-induced diabetic rats was investigated. The administration of SBH and PRE improved systemic antioxidant defense and oxidative stress-related measures without compromising liver and renal functioning. Analyses of the liver, skeletal muscle and adipose tissues revealed differences in their capacities to scavenge free radicals and halt lipid peroxidation. Transcriptional alterations hypothesised tissue-specific control of KEAP1-NRF2 signalling by upregulation of Nrf2, Ho1 and Sod1 in a tissue-specific manner. In addition, hepatic translational studies demonstrated the stimulation of downstream antioxidant-related protein with upregulated expression of SOD-1 and HOD-1 protein. Overall, the results indicated that PRE and SBH can be exploited to restore the oxidant-antioxidant imbalance generated by diabetes via regulating the KEAP1-NRF2 signalling pathway." @default.
- W4381805120 created "2023-06-24" @default.
- W4381805120 creator A5005805356 @default.
- W4381805120 creator A5046673765 @default.
- W4381805120 creator A5069798044 @default.
- W4381805120 creator A5079153355 @default.
- W4381805120 creator A5080343832 @default.
- W4381805120 creator A5080735931 @default.
- W4381805120 creator A5085899243 @default.
- W4381805120 date "2023-06-22" @default.
- W4381805120 modified "2023-09-30" @default.
- W4381805120 title "Stingless Bee (Heterotrigona Itama) Honey and Its Phenolic-Rich Extract Ameliorate Oxidant–Antioxidant Balance via KEAP1-NRF2 Signalling Pathway" @default.
- W4381805120 cites W1174839022 @default.
- W4381805120 cites W1481426999 @default.
- W4381805120 cites W1979731512 @default.
- W4381805120 cites W1980308976 @default.
- W4381805120 cites W1990412203 @default.
- W4381805120 cites W2013857037 @default.
- W4381805120 cites W2029132541 @default.
- W4381805120 cites W2041813594 @default.
- W4381805120 cites W2046561887 @default.
- W4381805120 cites W2064889863 @default.
- W4381805120 cites W2084141237 @default.
- W4381805120 cites W2086526886 @default.
- W4381805120 cites W2092769218 @default.
- W4381805120 cites W2103623970 @default.
- W4381805120 cites W2115337518 @default.
- W4381805120 cites W2136361542 @default.
- W4381805120 cites W2140780405 @default.
- W4381805120 cites W2172034700 @default.
- W4381805120 cites W2178581000 @default.
- W4381805120 cites W2484520098 @default.
- W4381805120 cites W2547134376 @default.
- W4381805120 cites W2652575518 @default.
- W4381805120 cites W2737200287 @default.
- W4381805120 cites W2748095317 @default.
- W4381805120 cites W2755606774 @default.
- W4381805120 cites W2775529898 @default.
- W4381805120 cites W2779347175 @default.
- W4381805120 cites W2783454183 @default.
- W4381805120 cites W2801393350 @default.
- W4381805120 cites W2820707192 @default.
- W4381805120 cites W2962762119 @default.
- W4381805120 cites W2976366656 @default.
- W4381805120 cites W2989279702 @default.
- W4381805120 cites W3001161839 @default.
- W4381805120 cites W3005457075 @default.
- W4381805120 cites W3014264983 @default.
- W4381805120 cites W3015784228 @default.
- W4381805120 cites W3036457333 @default.
- W4381805120 cites W3038041948 @default.
- W4381805120 cites W3117136930 @default.
- W4381805120 cites W3197178742 @default.
- W4381805120 cites W3210494598 @default.
- W4381805120 cites W4223542076 @default.
- W4381805120 cites W4224062070 @default.
- W4381805120 cites W4226161394 @default.
- W4381805120 cites W4312720700 @default.
- W4381805120 cites W598738849 @default.
- W4381805120 doi "https://doi.org/10.3390/nu15132835" @default.
- W4381805120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37447162" @default.
- W4381805120 hasPublicationYear "2023" @default.
- W4381805120 type Work @default.
- W4381805120 citedByCount "0" @default.
- W4381805120 crossrefType "journal-article" @default.
- W4381805120 hasAuthorship W4381805120A5005805356 @default.
- W4381805120 hasAuthorship W4381805120A5046673765 @default.
- W4381805120 hasAuthorship W4381805120A5069798044 @default.
- W4381805120 hasAuthorship W4381805120A5079153355 @default.
- W4381805120 hasAuthorship W4381805120A5080343832 @default.
- W4381805120 hasAuthorship W4381805120A5080735931 @default.
- W4381805120 hasAuthorship W4381805120A5085899243 @default.
- W4381805120 hasBestOaLocation W43818051201 @default.
- W4381805120 hasConcept C104317684 @default.
- W4381805120 hasConcept C127561419 @default.
- W4381805120 hasConcept C185592680 @default.
- W4381805120 hasConcept C2776151105 @default.
- W4381805120 hasConcept C2776529522 @default.
- W4381805120 hasConcept C2778004101 @default.
- W4381805120 hasConcept C2778027074 @default.
- W4381805120 hasConcept C2780829032 @default.
- W4381805120 hasConcept C31903555 @default.
- W4381805120 hasConcept C55493867 @default.
- W4381805120 hasConcept C71924100 @default.
- W4381805120 hasConcept C86339819 @default.
- W4381805120 hasConcept C98274493 @default.
- W4381805120 hasConceptScore W4381805120C104317684 @default.
- W4381805120 hasConceptScore W4381805120C127561419 @default.
- W4381805120 hasConceptScore W4381805120C185592680 @default.
- W4381805120 hasConceptScore W4381805120C2776151105 @default.
- W4381805120 hasConceptScore W4381805120C2776529522 @default.
- W4381805120 hasConceptScore W4381805120C2778004101 @default.
- W4381805120 hasConceptScore W4381805120C2778027074 @default.
- W4381805120 hasConceptScore W4381805120C2780829032 @default.
- W4381805120 hasConceptScore W4381805120C31903555 @default.
- W4381805120 hasConceptScore W4381805120C55493867 @default.
- W4381805120 hasConceptScore W4381805120C71924100 @default.
- W4381805120 hasConceptScore W4381805120C86339819 @default.