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- W4381839237 abstract "Background: Left atrial enlargement and fibrosis have been linked to the pathogenesis of atrial fibrillation (AF). We aimed to introduce a novel concept and develop a new procedure for AF treatment based on these characteristics. Methods: The study included three stages. The first stage was a descriptive study to clarify the characteristics of the left atrial enlargement and fibrosis’ distribution in patients with mitral valve disease and long-standing persistent AF. Based on these characteristics, we introduced a novel concept for AF treatment, and then translated it into a new procedure. The second stage was a proof-of-concept study with this new procedure. The third stage was a comparative effectiveness research to compare the clinical outcomes between patients with this new procedure and those who received Cox-Maze IV treatment. Results: Based on non-uniform fashion of left atrial enlargement and fibrosis’ distribution, we introduced a novel concept: reconstructing a left atrium with appropriate geometry and uniform fibrosis’ distribution for proper cardiac conduction, and translated it into a new procedure: left atrial geometric volume reduction combined with left appendage base closure. As compared to Cox-Maze IV procedure, the new procedure spent significantly shorter total surgery time, cardiopulmonary bypass time and aortic cross-clamp time (P<0.001). Besides, the new procedure was related to a shorter ICU stay period (OR=0.45, 95%CI=0.26-0.78), lower costs (OR=0.15, 95%CI=0.08-0.29) and a higher rate of A wave of transmitral and transtricuspid flow reappearance (OR=1.76, 95%CI=1.02-3.04). Conclusions: The new procedure is safe and effective for eliminating AF associated with mitral valve disease." @default.
- W4381839237 created "2023-06-25" @default.
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- W4381839237 date "2023-06-22" @default.
- W4381839237 modified "2023-10-11" @default.
- W4381839237 title "A new procedure for elimination of atrial fibrillation associated with mitral valve disease：a proof-of-concept study" @default.
- W4381839237 doi "https://doi.org/10.1097/js9.0000000000000566" @default.
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