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• W4381839585 abstract "With the change in global environment, respiratory disorders are becoming more threatening to the health of people all over the world. These diseases are closely linked to performance of immune system. Within the innate arm of immune system, Neutrophils are an important moiety to serve as an immune defense barrier. They are one of the first cells recruited to the site of infection and plays a critical role in pathogenesis of various pulmonary diseases. It is established that the migration and activation of neutrophils can lead to inflammation either directly or indirectly and this inflammation caused is very crucial for the clearance of pathogens and resolution of infection. However, the immunopathological mechanisms involved to carry out the same is very complex and not well understood. Despite there being studies concentrating on the role of neutrophils in multiple respiratory diseases, there is still a long way to go in order to completely understand the complexity of the participation of neutrophils and mechanisms involved in the development of these respiratory diseases. In the present article, we have reviewed the literature to comprehensively provide an insight in the current development and advancements about the role of neutrophils in infectious respiratory disorders including viral respiratory disorders such as Coronavirus disease (COVID-19) and bacterial pulmonary disorders with a focused review on pulmonary tuberculosis as well as in noninfectious disorders like Chronic obstructive pulmonary disease (COPD) and asthma. Also, future directions into research and therapeutic targets have been discussed for further exploration.Respiratory illnesses are becoming more prevalent and a substantial source of sickness and mortality worldwide as a result of the changes in the global environment. Although diagnostic and therapeutic approaches for respiratory disorders have improved over the years, a thorough and in-depth approach is still required to understand the underlying immuno-pathophysiological mechanisms. Neutrophils are a crucial part of innate immune system which functions as a first line defense against various pulmonary infections. They are known to be involved in resistance against invading pulmonary pathogens and also play an important role in repairing of damaged lung tissue by removing debris. However, emerging evidences suggest that neutrophils may also be involved in promoting and aggravating the unabating inflammation in several pulmonary disorders by release of various proteases, forming neutrophil extracellular traps or by attracting and activating other immune cells at the site of inflammation. In this article, we have discussed diverse roles and responses of neutrophils and their use in potential future research and therapeutic approaches in infectious pulmonary disorders like Tuberculosis and COVID-19 and noninfectious pulmonary disorders like Chronic obstructive pulmonary disease (COPD) and asthma." @default.
• W4381839585 created "2023-06-25" @default.
• W4381839585 creator A5011011876 @default.
• W4381839585 creator A5022896054 @default.
• W4381839585 date "2023-06-24" @default.
• W4381839585 modified "2023-09-27" @default.
• W4381839585 title "Exploring the role of neutrophils in infectious and noninfectious pulmonary disorders" @default.
• W4381839585 cites W1520991027 @default.
• W4381839585 cites W1531616236 @default.
• W4381839585 cites W1675847437 @default.
• W4381839585 cites W1739234479 @default.
• W4381839585 cites W1763507289 @default.
• W4381839585 cites W1814027404 @default.
• W4381839585 cites W1926302666 @default.
• W4381839585 cites W1961361211 @default.
• W4381839585 cites W1963626500 @default.
• W4381839585 cites W1964669406 @default.
• W4381839585 cites W1966050190 @default.
• W4381839585 cites W1966678873 @default.
• W4381839585 cites W1967270772 @default.
• W4381839585 cites W1973664534 @default.
• W4381839585 cites W1976646654 @default.
• W4381839585 cites W1981871099 @default.
• W4381839585 cites W1982948902 @default.
• W4381839585 cites W1983139081 @default.
• W4381839585 cites W1983247852 @default.
• W4381839585 cites W1990621187 @default.
• W4381839585 cites W1990674750 @default.
• W4381839585 cites W1992761610 @default.
• W4381839585 cites W2003544664 @default.
• W4381839585 cites W2008882251 @default.
• W4381839585 cites W2014262351 @default.
• W4381839585 cites W2014693052 @default.
• W4381839585 cites W2016029872 @default.
• W4381839585 cites W2016355432 @default.
• W4381839585 cites W2022384658 @default.
• W4381839585 cites W2023280240 @default.
• W4381839585 cites W2024949965 @default.
• W4381839585 cites W2036965973 @default.
• W4381839585 cites W2045819100 @default.
• W4381839585 cites W2048801137 @default.
• W4381839585 cites W2049934590 @default.
• W4381839585 cites W2051930121 @default.
• W4381839585 cites W2068466537 @default.
• W4381839585 cites W2072322888 @default.
• W4381839585 cites W2074724331 @default.
• W4381839585 cites W2080536634 @default.
• W4381839585 cites W2081325862 @default.
• W4381839585 cites W2084141237 @default.
• W4381839585 cites W2085945130 @default.
• W4381839585 cites W2087763300 @default.
• W4381839585 cites W2091662968 @default.
• W4381839585 cites W2093023410 @default.
• W4381839585 cites W2093940946 @default.
• W4381839585 cites W2094289253 @default.
• W4381839585 cites W2094908805 @default.
• W4381839585 cites W2100461999 @default.
• W4381839585 cites W2102011095 @default.
• W4381839585 cites W2102888433 @default.
• W4381839585 cites W2106248075 @default.
• W4381839585 cites W2106582806 @default.
• W4381839585 cites W2112200553 @default.
• W4381839585 cites W2114695306 @default.
• W4381839585 cites W2118217258 @default.
• W4381839585 cites W2118228748 @default.
• W4381839585 cites W2119636028 @default.
• W4381839585 cites W2119724532 @default.
• W4381839585 cites W2123547619 @default.
• W4381839585 cites W2125762027 @default.
• W4381839585 cites W2127882921 @default.
• W4381839585 cites W2129081132 @default.
• W4381839585 cites W2129823429 @default.
• W4381839585 cites W2130608493 @default.
• W4381839585 cites W2131917465 @default.
• W4381839585 cites W2133896129 @default.
• W4381839585 cites W2136349095 @default.
• W4381839585 cites W2137298291 @default.
• W4381839585 cites W2137522692 @default.
• W4381839585 cites W2137665452 @default.
• W4381839585 cites W2138843880 @default.
• W4381839585 cites W2138892734 @default.
• W4381839585 cites W2139480869 @default.
• W4381839585 cites W2142436361 @default.
• W4381839585 cites W2145181045 @default.
• W4381839585 cites W2148750103 @default.
• W4381839585 cites W2152502508 @default.
• W4381839585 cites W2155283077 @default.
• W4381839585 cites W2156400407 @default.
• W4381839585 cites W2157653043 @default.
• W4381839585 cites W2161619131 @default.
• W4381839585 cites W2162723764 @default.
• W4381839585 cites W2162789710 @default.
• W4381839585 cites W2163529289 @default.
• W4381839585 cites W2165485317 @default.
• W4381839585 cites W2165658158 @default.
• W4381839585 cites W2165892419 @default.
• W4381839585 cites W2168177150 @default.
• W4381839585 cites W2168796298 @default.

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