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• W4381848178 abstract "ObjectiveThe participation of patients with advanced cancer(s) in clinical trials is vital for new drug development. We aimed to investigate patients’ decision-making processes and satisfaction with their decision to participate (SWD); the study’s purpose was to provide results that can help support high-quality research in clinical trials. In addition, we explored how shared decision-making (SDM) mediates the relationship between understanding informed consent forms and SWD to participate in a clinical trial.MethodsA cross-sectional study was conducted. A purposive sample of 111 cancer patients was recruited, and they completed a questionnaire on demographic characteristics, SDM, and decision-making satisfaction to participate in a clinical trial. Correlation and mediation analyses were used.ResultsParticipants under 65 and with higher education reported high SWDs, and SDM significantly mediated the relationship between self-assessed understanding of informed consent forms and SWDs related to clinical trials.ConclusionsSDM in patients with lung or liver cancer was a significant mediator between understanding the informed consent form and the patient’s SWD. The higher the SWD level of participating in clinical trials, the better study team members’ SDM involvement and the better the comprehension of informed consent forms. In addition, patients’ age and education level should also be considered influencing factors in SWD. This survey is the first in Taiwan to examine SDM in drug-related clinical trials. The study results provide evidence to support SDM in a clinical trial model and develop informed consent process policies in research facilities." @default.
• W4381848178 created "2023-06-25" @default.
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• W4381848178 date "2023-08-01" @default.
• W4381848178 modified "2023-10-17" @default.
• W4381848178 title "The mediating effect of shared decision-making in enhancing patient satisfaction with participation in cancer clinical trials" @default.
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• W4381848178 doi "https://doi.org/10.1016/j.apjon.2023.100265" @default.
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