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- W4381848533 abstract "We carefully read the study of Martín-González et al. examining the relationship between mean platelet volume (MPV) and mortality in patients with alcohol use disorder [ [1] Martín-González C., Ribot-Hernández I., Fernández-Rodríguez C.M., et al. Mean platelet volume and mortality in patients with alcohol use disorder. Dig Liver Dis, doi:10.1016/j.dld.2023.05.022. Google Scholar ]. They found that MPV values were associated with the inflammatory cytokines tumor necrosis factor-alpha, interleukin-8, and interleukin-6 and that decreased MPV value was associated with both short-term and long-term mortality. They suggested that decreased MPV value indicates poor prognosis among patients with alcohol use disorder. In this study, we would like to express the existence of some factors that may have adversely affected MPV results and may have led to erroneous interpretations. Mean platelet volume and mortality in patients with alcohol use disorderDigestive and Liver DiseaseVol. 55Issue 9PreviewSeveral recent studies have pointed out the relationship of platelet size with increased mortality or adverse clinical course. Most studies show that increased mean platelet volume (MPV) may be associated with a deleterious outcome in different settings such as sepsis or neoplasia, whereas other researchers have found the opposite. In inflammatory conditions there is an altered secretion of several cytokines, some of them exerting a marked influence on platelet biogenesis and/or on platelet activation and aggregation. Full-Text PDF Open Access" @default.
- W4381848533 created "2023-06-25" @default.
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- W4381848533 date "2023-10-01" @default.
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- W4381848533 title "Mean platelet volume may not be an indicator for prognosis in patients with alcohol use disorder" @default.
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- W4381848533 doi "https://doi.org/10.1016/j.dld.2023.06.013" @default.
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