Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381850042> ?p ?o ?g. }
- W4381850042 endingPage "104664" @default.
- W4381850042 startingPage "104664" @default.
- W4381850042 abstract "Oral absorption and room temperature storage remain two major challenges limiting the bioavailability of recombinant human growth hormone (rhGH) due to the need to overcome the unfavorable gastrointestinal environment and resist temperature effects on rhGH structure, Therefore, we designed a multifunctional nanoplatform to address both problems simultaneously. The carrier consists of PLGA, ionic liquid (IL) and deoxycholic acid (DCA). In this nanosystem, IL acts as a green non-toxic solvent and helps the nanoparticles to open tight junctions between cells, and acts as a room temperature protectant to improve the room temperature stability of rhGH. Endogenous DCA as a ligand increases intestinal absorption of nanoparticles through receptor-mediated endocytosis. The nanoparticles have the following advantages: 1) Protects rhGH in the gastrointestinal tract from being degraded by gastric acid and proteases. 2) The absorption of rhGH in intestinal tract was increased and its bioavailability was enhanced. 3) The storage time of rhGH at room temperature was prolonged. These materials are cheap, readily available and easily synthesized and these studies provide a basis for the clinical application of rhGH." @default.
- W4381850042 created "2023-06-25" @default.
- W4381850042 creator A5026231812 @default.
- W4381850042 creator A5029359864 @default.
- W4381850042 creator A5039133027 @default.
- W4381850042 creator A5055174519 @default.
- W4381850042 creator A5058599920 @default.
- W4381850042 creator A5071086210 @default.
- W4381850042 creator A5081561154 @default.
- W4381850042 creator A5085415981 @default.
- W4381850042 date "2023-09-01" @default.
- W4381850042 modified "2023-09-25" @default.
- W4381850042 title "Ionic liquid combined with bile acid pathway for oral delivery of rhGH" @default.
- W4381850042 cites W1011520582 @default.
- W4381850042 cites W1511036913 @default.
- W4381850042 cites W1973158756 @default.
- W4381850042 cites W1974056971 @default.
- W4381850042 cites W1979245725 @default.
- W4381850042 cites W1984548348 @default.
- W4381850042 cites W2003530563 @default.
- W4381850042 cites W2012539929 @default.
- W4381850042 cites W2029514712 @default.
- W4381850042 cites W2041988114 @default.
- W4381850042 cites W2047534346 @default.
- W4381850042 cites W2052239784 @default.
- W4381850042 cites W2060292269 @default.
- W4381850042 cites W2064281079 @default.
- W4381850042 cites W2066646178 @default.
- W4381850042 cites W2074979419 @default.
- W4381850042 cites W2075234837 @default.
- W4381850042 cites W2077361512 @default.
- W4381850042 cites W2078639851 @default.
- W4381850042 cites W2083666482 @default.
- W4381850042 cites W2091690415 @default.
- W4381850042 cites W2180519749 @default.
- W4381850042 cites W2499371617 @default.
- W4381850042 cites W2514640387 @default.
- W4381850042 cites W2602315347 @default.
- W4381850042 cites W2752697009 @default.
- W4381850042 cites W2756011546 @default.
- W4381850042 cites W2789600782 @default.
- W4381850042 cites W2809845028 @default.
- W4381850042 cites W2810098751 @default.
- W4381850042 cites W2903293966 @default.
- W4381850042 cites W2908903548 @default.
- W4381850042 cites W2931814280 @default.
- W4381850042 cites W2972856019 @default.
- W4381850042 cites W3098944663 @default.
- W4381850042 cites W3131565642 @default.
- W4381850042 cites W3170874205 @default.
- W4381850042 cites W2531323781 @default.
- W4381850042 doi "https://doi.org/10.1016/j.jddst.2023.104664" @default.
- W4381850042 hasPublicationYear "2023" @default.
- W4381850042 type Work @default.
- W4381850042 citedByCount "0" @default.
- W4381850042 crossrefType "journal-article" @default.
- W4381850042 hasAuthorship W4381850042A5026231812 @default.
- W4381850042 hasAuthorship W4381850042A5029359864 @default.
- W4381850042 hasAuthorship W4381850042A5039133027 @default.
- W4381850042 hasAuthorship W4381850042A5055174519 @default.
- W4381850042 hasAuthorship W4381850042A5058599920 @default.
- W4381850042 hasAuthorship W4381850042A5071086210 @default.
- W4381850042 hasAuthorship W4381850042A5081561154 @default.
- W4381850042 hasAuthorship W4381850042A5085415981 @default.
- W4381850042 hasBestOaLocation W43818500422 @default.
- W4381850042 hasConcept C11268172 @default.
- W4381850042 hasConcept C125287762 @default.
- W4381850042 hasConcept C154881586 @default.
- W4381850042 hasConcept C155672457 @default.
- W4381850042 hasConcept C159985019 @default.
- W4381850042 hasConcept C161790260 @default.
- W4381850042 hasConcept C170493617 @default.
- W4381850042 hasConcept C171250308 @default.
- W4381850042 hasConcept C178790620 @default.
- W4381850042 hasConcept C181389837 @default.
- W4381850042 hasConcept C184651966 @default.
- W4381850042 hasConcept C185592680 @default.
- W4381850042 hasConcept C192562407 @default.
- W4381850042 hasConcept C2779399885 @default.
- W4381850042 hasConcept C2780512811 @default.
- W4381850042 hasConcept C2780749602 @default.
- W4381850042 hasConcept C28005876 @default.
- W4381850042 hasConcept C55493867 @default.
- W4381850042 hasConcept C71924100 @default.
- W4381850042 hasConcept C98274493 @default.
- W4381850042 hasConceptScore W4381850042C11268172 @default.
- W4381850042 hasConceptScore W4381850042C125287762 @default.
- W4381850042 hasConceptScore W4381850042C154881586 @default.
- W4381850042 hasConceptScore W4381850042C155672457 @default.
- W4381850042 hasConceptScore W4381850042C159985019 @default.
- W4381850042 hasConceptScore W4381850042C161790260 @default.
- W4381850042 hasConceptScore W4381850042C170493617 @default.
- W4381850042 hasConceptScore W4381850042C171250308 @default.
- W4381850042 hasConceptScore W4381850042C178790620 @default.
- W4381850042 hasConceptScore W4381850042C181389837 @default.
- W4381850042 hasConceptScore W4381850042C184651966 @default.
- W4381850042 hasConceptScore W4381850042C185592680 @default.
- W4381850042 hasConceptScore W4381850042C192562407 @default.