FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381850315> ?p ?o ?g. }

• W4381850315 endingPage "1155.e4" @default.
• W4381850315 startingPage "1144" @default.
• W4381850315 abstract "Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. We recently discovered that neuronal regeneration-related protein (NREP/P311), an epigenetically regulated gene reprogrammed by parental metabolic syndrome, is downregulated in human NAFLD. To investigate the impact of NREP insufficiency, we used RNA-sequencing, lipidomics, and antibody microarrays on primary human hepatocytes. NREP knockdown induced transcriptomic remodeling that overlapped with key pathways impacted in human steatosis and steatohepatitis. Additionally, we observed enrichment of pathways involving phosphatidylinositol signaling and one-carbon metabolism. Lipidomics analyses also revealed an increase in cholesterol esters and triglycerides and decreased phosphatidylcholine levels in NREP-deficient hepatocytes. Signalomics identified calcium signaling as a potential mediator of NREP insufficiency’s effects. Our results, together with the encouraging observation that several single nucleotide polymorphisms (SNPs) spanning the NREP locus are associated with metabolic traits, provide a strong rationale for targeting hepatic NREP to improve NAFLD pathophysiology." @default.
• W4381850315 created "2023-06-25" @default.
• W4381850315 creator A5042315373 @default.
• W4381850315 creator A5045869434 @default.
• W4381850315 creator A5083294804 @default.
• W4381850315 creator A5087698300 @default.
• W4381850315 date "2023-09-01" @default.
• W4381850315 modified "2023-10-17" @default.
• W4381850315 title "NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes" @default.
• W4381850315 cites W1546286343 @default.
• W4381850315 cites W1993652778 @default.
• W4381850315 cites W1994605397 @default.
• W4381850315 cites W2031131470 @default.
• W4381850315 cites W2034317592 @default.
• W4381850315 cites W2083192581 @default.
• W4381850315 cites W2085251552 @default.
• W4381850315 cites W2086947816 @default.
• W4381850315 cites W2093824918 @default.
• W4381850315 cites W2095900642 @default.
• W4381850315 cites W2110256992 @default.
• W4381850315 cites W2123500593 @default.
• W4381850315 cites W2124649657 @default.
• W4381850315 cites W2134167042 @default.
• W4381850315 cites W2146512944 @default.
• W4381850315 cites W2153974854 @default.
• W4381850315 cites W2158422709 @default.
• W4381850315 cites W2169067272 @default.
• W4381850315 cites W2182856316 @default.
• W4381850315 cites W2298645640 @default.
• W4381850315 cites W2412148034 @default.
• W4381850315 cites W2509717357 @default.
• W4381850315 cites W2536412663 @default.
• W4381850315 cites W2553298154 @default.
• W4381850315 cites W2589097437 @default.
• W4381850315 cites W2605431828 @default.
• W4381850315 cites W2609371482 @default.
• W4381850315 cites W2612989432 @default.
• W4381850315 cites W2683363718 @default.
• W4381850315 cites W2759997926 @default.
• W4381850315 cites W2760988474 @default.
• W4381850315 cites W2766761391 @default.
• W4381850315 cites W2794200923 @default.
• W4381850315 cites W2804408552 @default.
• W4381850315 cites W2810762819 @default.
• W4381850315 cites W2905995230 @default.
• W4381850315 cites W2920594898 @default.
• W4381850315 cites W2924975078 @default.
• W4381850315 cites W2941112903 @default.
• W4381850315 cites W2946849576 @default.
• W4381850315 cites W2951912016 @default.
• W4381850315 cites W2964606140 @default.
• W4381850315 cites W2971733377 @default.
• W4381850315 cites W2994930208 @default.
• W4381850315 cites W2999527080 @default.
• W4381850315 cites W3014319237 @default.
• W4381850315 cites W3118192526 @default.
• W4381850315 cites W3129180292 @default.
• W4381850315 cites W3160163020 @default.
• W4381850315 cites W4200408214 @default.
• W4381850315 cites W4248772239 @default.
• W4381850315 doi "https://doi.org/10.1016/j.chembiol.2023.06.001" @default.
• W4381850315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37354909" @default.
• W4381850315 hasPublicationYear "2023" @default.
• W4381850315 type Work @default.
• W4381850315 citedByCount "0" @default.
• W4381850315 crossrefType "journal-article" @default.
• W4381850315 hasAuthorship W4381850315A5042315373 @default.
• W4381850315 hasAuthorship W4381850315A5045869434 @default.
• W4381850315 hasAuthorship W4381850315A5083294804 @default.
• W4381850315 hasAuthorship W4381850315A5087698300 @default.
• W4381850315 hasConcept C104317684 @default.
• W4381850315 hasConcept C126322002 @default.
• W4381850315 hasConcept C134018914 @default.
• W4381850315 hasConcept C135763542 @default.
• W4381850315 hasConcept C153209595 @default.
• W4381850315 hasConcept C2107291 @default.
• W4381850315 hasConcept C2776175330 @default.
• W4381850315 hasConcept C2778772119 @default.
• W4381850315 hasConcept C2779134260 @default.
• W4381850315 hasConcept C2779478299 @default.
• W4381850315 hasConcept C4733338 @default.
• W4381850315 hasConcept C54355233 @default.
• W4381850315 hasConcept C58017582 @default.
• W4381850315 hasConcept C60644358 @default.
• W4381850315 hasConcept C71924100 @default.
• W4381850315 hasConcept C86803240 @default.
• W4381850315 hasConcept C95444343 @default.
• W4381850315 hasConceptScore W4381850315C104317684 @default.
• W4381850315 hasConceptScore W4381850315C126322002 @default.
• W4381850315 hasConceptScore W4381850315C134018914 @default.
• W4381850315 hasConceptScore W4381850315C135763542 @default.
• W4381850315 hasConceptScore W4381850315C153209595 @default.
• W4381850315 hasConceptScore W4381850315C2107291 @default.
• W4381850315 hasConceptScore W4381850315C2776175330 @default.
• W4381850315 hasConceptScore W4381850315C2778772119 @default.
• W4381850315 hasConceptScore W4381850315C2779134260 @default.
• W4381850315 hasConceptScore W4381850315C2779478299 @default.
• W4381850315 hasConceptScore W4381850315C4733338 @default.

• next