FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381851507> ?p ?o ?g. }

• W4381851507 endingPage "224" @default.
• W4381851507 startingPage "207" @default.
• W4381851507 abstract "Interleukin-6 (IL-6) is a cytokine synthesized by many cells in the human body. IL-6 binds to a membrane-bound receptor (IL-6R), which is only present on hepatocytes, some epithelial cells, and some leukocytes. The complex of IL-6 and IL-6R binds to the ubiquitously expressed receptor subunit gp130, which forms a homodimer and thereby initiates intracellular signaling, e.g., the JAK/STAT and MAPK pathways. Proteases can cleave the membrane-bound IL-6R from the cell surface and generate a soluble IL-6R (sIL-6R), which retains its ability to bind IL-6. The IL-6/sIL-6R complex associates with gp130 and induces signaling even on cells which do not express the IL-6R. This paradigm has been called IL-6 trans-signaling, whereas signaling via the membrane-bound IL-6R is referred to as classic signaling. We have generated several molecular tools to differentiate between both pathways and to analyze the consequences of cellular IL-6 signaling in vivo. One of these tools is soluble gp130Fc, which selectively inhibits IL-6 trans-signaling. This protein under the WHO name Olamkicept has successfully undergone phase II clinical trials in patients with autoimmune diseases. Here, in this chapter, we describe several molecular tools to differentiate between IL-6 classic and trans-signaling and to analyze the consequences of cellular IL-6 signaling in vivo." @default.
• W4381851507 created "2023-06-25" @default.
• W4381851507 creator A5025552082 @default.
• W4381851507 creator A5089057275 @default.
• W4381851507 date "2023-01-01" @default.
• W4381851507 modified "2023-09-24" @default.
• W4381851507 title "Dissecting Interleukin-6 Classic and Trans-signaling in Inflammation and Cancer" @default.
• W4381851507 cites W1487227918 @default.
• W4381851507 cites W1597588755 @default.
• W4381851507 cites W1707503595 @default.
• W4381851507 cites W1776476655 @default.
• W4381851507 cites W1810441673 @default.
• W4381851507 cites W1849537180 @default.
• W4381851507 cites W1858549592 @default.
• W4381851507 cites W1904767156 @default.
• W4381851507 cites W1904816508 @default.
• W4381851507 cites W1971308765 @default.
• W4381851507 cites W1979540550 @default.
• W4381851507 cites W1982134009 @default.
• W4381851507 cites W1994607862 @default.
• W4381851507 cites W1996548067 @default.
• W4381851507 cites W2005432188 @default.
• W4381851507 cites W2011400811 @default.
• W4381851507 cites W2012967865 @default.
• W4381851507 cites W2015200774 @default.
• W4381851507 cites W2017223857 @default.
• W4381851507 cites W2036439151 @default.
• W4381851507 cites W2036988498 @default.
• W4381851507 cites W2038479043 @default.
• W4381851507 cites W2040736784 @default.
• W4381851507 cites W2046396043 @default.
• W4381851507 cites W2074944279 @default.
• W4381851507 cites W2077231697 @default.
• W4381851507 cites W2082626794 @default.
• W4381851507 cites W2082974347 @default.
• W4381851507 cites W2085433278 @default.
• W4381851507 cites W2086624123 @default.
• W4381851507 cites W2087639358 @default.
• W4381851507 cites W2092511207 @default.
• W4381851507 cites W2100478793 @default.
• W4381851507 cites W2102768377 @default.
• W4381851507 cites W2104859674 @default.
• W4381851507 cites W2111091679 @default.
• W4381851507 cites W2112019903 @default.
• W4381851507 cites W2114853101 @default.
• W4381851507 cites W2117521006 @default.
• W4381851507 cites W2122402883 @default.
• W4381851507 cites W2124173277 @default.
• W4381851507 cites W2152181022 @default.
• W4381851507 cites W2157233685 @default.
• W4381851507 cites W2165332266 @default.
• W4381851507 cites W2165797008 @default.
• W4381851507 cites W2226127569 @default.
• W4381851507 cites W2266423547 @default.
• W4381851507 cites W2319958192 @default.
• W4381851507 cites W2532470837 @default.
• W4381851507 cites W2558510664 @default.
• W4381851507 cites W2566679826 @default.
• W4381851507 cites W2625304812 @default.
• W4381851507 cites W2771055284 @default.
• W4381851507 cites W2783733036 @default.
• W4381851507 cites W2789334209 @default.
• W4381851507 cites W2793384878 @default.
• W4381851507 cites W2794173683 @default.
• W4381851507 cites W2802379102 @default.
• W4381851507 cites W2946801582 @default.
• W4381851507 cites W2952979335 @default.
• W4381851507 cites W3133637024 @default.
• W4381851507 cites W3144922262 @default.
• W4381851507 cites W3168121042 @default.
• W4381851507 cites W3193523037 @default.
• W4381851507 cites W3200789175 @default.
• W4381851507 cites W3205881691 @default.
• W4381851507 cites W4246291556 @default.
• W4381851507 cites W4285742707 @default.
• W4381851507 cites W4306252862 @default.
• W4381851507 doi "https://doi.org/10.1007/978-1-0716-3331-1_16" @default.
• W4381851507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37355548" @default.
• W4381851507 hasPublicationYear "2023" @default.
• W4381851507 type Work @default.
• W4381851507 citedByCount "0" @default.
• W4381851507 crossrefType "book-chapter" @default.
• W4381851507 hasAuthorship W4381851507A5025552082 @default.
• W4381851507 hasAuthorship W4381851507A5089057275 @default.
• W4381851507 hasConcept C126037660 @default.
• W4381851507 hasConcept C150555746 @default.
• W4381851507 hasConcept C170493617 @default.
• W4381851507 hasConcept C203014093 @default.
• W4381851507 hasConcept C2778690821 @default.
• W4381851507 hasConcept C2778923194 @default.
• W4381851507 hasConcept C55493867 @default.
• W4381851507 hasConcept C62478195 @default.
• W4381851507 hasConcept C74172505 @default.
• W4381851507 hasConcept C86803240 @default.
• W4381851507 hasConcept C95444343 @default.
• W4381851507 hasConcept C98119934 @default.
• W4381851507 hasConceptScore W4381851507C126037660 @default.
• W4381851507 hasConceptScore W4381851507C150555746 @default.

• next