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- W4381856360 abstract "Abstract Brain pericytes are critical for regulating endothelial barrier function and activity, thus ensuring adequate blood flow to the brain. The genetic pathways guiding undifferentiated cells into mature pericytes are not well understood. We show here that precursor populations from both neural crest and head mesoderm express the transcription factor nkx3.1 develop into brain pericytes. We identify the gene signature of these precursors, and show that an nkx3.1, foxf2a , and cxcl12b -expressing pericyte precursor population is present around the basilar artery prior to artery formation and pericyte recruitment. The precursors later spread throughout the brain and differentiate to express canonical pericyte markers. Cxcl12b-Cxcr4 signaling is required for pericyte attachment and differentiation. Further, both nkx3.1 and cxcl12 b are necessary and sufficient in regulating pericyte number as loss inhibits and gain increases pericyte number. Through genetic experiments we have defined a precursor population for brain pericytes and identified genes critical for their differentiation." @default.
- W4381856360 created "2023-06-25" @default.
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- W4381856360 date "2023-06-22" @default.
- W4381856360 modified "2023-10-16" @default.
- W4381856360 title "A genetic program for vascular pericyte precursors" @default.
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- W4381856360 doi "https://doi.org/10.1101/2023.06.21.545941" @default.
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