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• W4381885503 endingPage "109409" @default.
• W4381885503 startingPage "109409" @default.
• W4381885503 abstract "Tissue/cellular actions of butyrate on energy metabolism and intestinal barrier in normal metabolic conditions or prediabetes are still unclear. In this work, we investigated the beneficial effect of dietary supplementation with sodium butyrate on energy metabolism, body mass composition, and intestinal epithelial barrier mediated by tight junction (TJ) in chow diet-fed normal and high-fat diet (HF)-fed prediabetic mice, considering the well-known butyrate action as an epigenetic and inflammatory regulator. Butyrate significantly reduced the fat/lean mass ratio, slightly ameliorated dyslipidemia, restored oral glucose tolerance, and increased basal energy expenditure in prediabetic HF-fed mice but had no effect on control animals. Such effects were observed in the absence of significant alterations in the hypothalamic expression of orexigenic and anorexigenic genes and motor activity. Also, butyrate suppressed the whitening effect of HF on brown adipose tissue but did not affect cell bioenergetics in immortalized UCP1-positive adipocytes in vitro. Butyrate reinforced the intestinal epithelial barrier in HF-fed mice and in Caco-2 monolayers, which involved higher trafficking of TJ proteins to the cell-cell contact region of the intestinal epithelia, without affecting TJ gene expression or the acetylation level of histones H3 and H4 in vivo. All metabolic and intestinal effects of butyrate in prediabetic mice occurred in the absence of detectable changes in systemic or local inflammation, or alterations in endotoxemia markers. Butyrate has no effect on chow diet-fed mice but, in the context of HF-induced prediabetes, it prevents metabolic and intestinal dysfunctions independently of its anti-inflammatory and epigenetic actions." @default.
• W4381885503 created "2023-06-25" @default.
• W4381885503 creator A5002773978 @default.
• W4381885503 creator A5008217736 @default.
• W4381885503 creator A5018372390 @default.
• W4381885503 creator A5018443469 @default.
• W4381885503 creator A5022080816 @default.
• W4381885503 creator A5025962777 @default.
• W4381885503 creator A5048638699 @default.
• W4381885503 creator A5065211643 @default.
• W4381885503 creator A5066994848 @default.
• W4381885503 creator A5089990483 @default.
• W4381885503 date "2023-10-01" @default.
• W4381885503 modified "2023-10-06" @default.
• W4381885503 title "Butyrate restores the fat/lean mass ratio balance and energy metabolism and reinforces the tight junction-mediated intestinal epithelial barrier in prediabetic mice independently of its anti-inflammatory and epigenetic actions" @default.
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