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• W4381888131 abstract "Objectives Mycobacterium abscessus complex is responsible for 2.6%–13.0% of all non-tuberculous mycobacterial pulmonary infections and these are notoriously difficult to treat due to the complex regimens required, drug resistance and adverse effects. Hence, bacteriophages have been considered in clinical practice as an additional treatment option. Here, we evaluated antibiotic and phage susceptibility profiles of M. abscessus clinical isolates. Whole genome sequencing (WGS) revealed the phylogenetic relationships, dominant circulating clones (DCC), the likelihood of patient-to-patient transmission and the presence of prophages. Methods Antibiotic susceptibility testing was performed using CLSI breakpoints (n = 95), and plaque assays were used for phage susceptibility testing (subset of n = 88, 35 rough and 53 smooth morphology). WGS was completed using the Illumina platform and analysed using Snippy/snp-dists and DEPhT. Results Amikacin and Tigecycline were the most active drugs (with two strains resistant to Amikacin, and one strain with Tigecycline MIC of 4 μg/ml). Most strains were resistant to all other drugs tested, with Linezolid and Imipenem showing the least resistance, at 38% (36/95) and 55% (52/95), respectively. Rough colony morphotype strains were more phage-susceptible than smooth strains (77% - 27/35 - versus 48% - 25/53 - in the plaque assays, but smooth strains are not killed efficiently by those phages in liquid infection assay). We have also identified 100 resident prophages, some of which were propagated lytically. DCC1 (20% - 18/90) and DCC4 (22% - 20/90) were observed to be the major clones and WGS identified six events of possible patient-to-patient transmission. Conclusion Many strains of M. abscessus complex are intrinsically resistant to available antibiotics and bacteriophages represent an alternative therapeutic option, but only for strains with rough morphology. Further studies are needed to elucidate the role of hospital-borne M. abscessus transmission." @default.
• W4381888131 created "2023-06-25" @default.
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• W4381888131 date "2023-10-01" @default.
• W4381888131 modified "2023-09-27" @default.
• W4381888131 title "The problem of Mycobacterium abscessus complex: multi-drug resistance, bacteriophage susceptibility and potential healthcare transmission" @default.
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• W4381888131 doi "https://doi.org/10.1016/j.cmi.2023.06.026" @default.
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• W4381888131 hasPublicationYear "2023" @default.
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