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• W4381891946 abstract "Abstract Background Psychopathy is characterized by antisocial behavior, poor behavioral control and lacking empathy, and structural alterations in the corresponding neural circuits. Molecular brain basis of psychopathy remains poorly characterized. Methods Here we studied type 2 dopamine receptor (D2R) and mu-opioid receptor (MOR) availability in convicted violent offenders with high psychopathic traits (n=11) and healthy matched controls (n=19) using positron emission tomography (PET). D2R were measured with radioligand [ 11 C]raclopride and MORs with radioligand [ 11 C]carfentanil. Results Psychopathic subjects had lowered D2R availability in caudate and putamen, and D2R striatal availability was also associated with degree of psychopathic traits in this prisoner sample. No group differences were found in MOR availability, although in the prisoner sample, psychopathic traits were negatively correlated with MOR availability amygdala and nucleus accumbens. Conclusions We conclude that D2R signaling could be the putative neuromolecular pathway for psychopathy, whereas evidence for the aberrant MOR system is more limited." @default.
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• W4381891946 date "2023-06-24" @default.
• W4381891946 modified "2023-10-02" @default.
• W4381891946 title "Aberrant type 2 dopamine receptor availability in criminal psychopathy" @default.
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• W4381891946 doi "https://doi.org/10.1101/2023.06.21.545877" @default.
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