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- W4381894152 abstract "Objectives Lung adenocarcinoma associated with cystic airspaces (LACA) is a unique entity with limited understanding. Our aim was to evaluate the radiological characteristics of LACA and to study which criteria were predictive of invasiveness. Methods A retrospective monocentric analysis of consecutive patients with pathologically confirmed LACA was performed. The diagnosed adenocarcinomas were classified into preinvasive (atypical adenomatous hyperplasia, adenocarcinoma in situ, or minimally invasive adenocarcinoma) and invasive adenocarcinomas. Eight clinical features and twelve CT features were evaluated. Univariable and multivariable analyses were performed to analyse the correlation between invasiveness, and CT and clinical features. The inter-observer agreement was evaluated using κ statistics and intraclass correlation coefficients. The predictive performance of the model was evaluated using the area under the receiver operating characteristic curve (AUC). Results A total of 252 patients with 265 lesions (128 men and 124 women; mean age, 58.0±11.1 years) were enrolled. Multivariable logistic regression indicated that multiple cystic airspaces (OR, 5.599; 95% CI, 1.865-16.802), irregular shape of cystic airspace (OR, 3.236; 95% CI, 1.073-9.761), entire tumour size (OR, 1.281; 95% CI, 1.075–1.526), and attenuation (OR, 1.007; 95% CI, 1.005–1.010) were independent risk factors for invasive LACA. The AUC of the logistic regression model was 0.964 (95% CI, 0.944-0.985). Conclusion Multiple cystic airspaces, irregular shape of cystic airspace, entire tumour size, and attenuation were identified as independent risk factors for invasive LACA. The prediction model gives a good predictive performance, providing additional diagnostic information." @default.
- W4381894152 created "2023-06-25" @default.
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- W4381894152 date "2023-08-01" @default.
- W4381894152 modified "2023-10-14" @default.
- W4381894152 title "Lung adenocarcinoma associated with cystic airspaces: Predictive value of CT features in assessing pathologic invasiveness" @default.
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- W4381894152 doi "https://doi.org/10.1016/j.ejrad.2023.110947" @default.
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