FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381929713> ?p ?o ?g. }

• W4381929713 abstract "Introduction Although SARS-CoV-2 infection can lead to severe COVID-19 in children, the role of biomarkers for assessing the risk of progression to severe disease is not well established in the pediatric population. Given the differences in monocyte signatures associated with worsening COVID-19 in adults, we aimed to determine whether monocyte anisocytosis early in the infectious course would correspond with increasing severity of COVID-19 in children. Methods We performed a multicenter retrospective study of 215 children with SARS-CoV-2 infection, Multisystem Inflammatory Syndrome in Children (MIS-C), convalescent COVID-19, and healthy age-matched controls to determine whether monocyte anisocytosis, quantified by monocyte distribution width (MDW) on complete blood count, was associated with increasing severity of COVID-19. We performed exploratory analyses to identify other hematologic parameters in the inflammatory signature of pediatric SARS-CoV-2 infection and determine the most effective combination of markers for assessing COVID-19 severity in children. Results Monocyte anisocytosis increases with COVID-19 severity and need for hospitalization. Although other inflammatory markers such as lymphocyte count, neutrophil/lymphocyte ratio, C-reactive protein, and cytokines correlate with disease severity, these parameters were not as sensitive as MDW for identifying severe disease in children. An MDW threshold of 23 offers a sensitive marker for severe pediatric COVID-19, with improved accuracy when assessed in combination with other hematologic parameters. Conclusion Monocyte anisocytosis corresponds with shifting hematologic profiles and inflammatory markers in children with COVID-19, and MDW serves as a clinically accessible biomarker for severe COVID-19 in children." @default.
• W4381929713 created "2023-06-25" @default.
• W4381929713 creator A5011315216 @default.
• W4381929713 creator A5019729863 @default.
• W4381929713 creator A5033552715 @default.
• W4381929713 creator A5063658652 @default.
• W4381929713 creator A5066034005 @default.
• W4381929713 creator A5067177144 @default.
• W4381929713 creator A5068141892 @default.
• W4381929713 creator A5074348958 @default.
• W4381929713 creator A5076825767 @default.
• W4381929713 creator A5089858754 @default.
• W4381929713 date "2023-06-23" @default.
• W4381929713 modified "2023-09-24" @default.
• W4381929713 title "Monocyte anisocytosis corresponds with increasing severity of COVID-19 in children" @default.
• W4381929713 cites W2336490219 @default.
• W4381929713 cites W2625249854 @default.
• W4381929713 cites W2802511398 @default.
• W4381929713 cites W2945881004 @default.
• W4381929713 cites W3020992444 @default.
• W4381929713 cites W3022702097 @default.
• W4381929713 cites W3033161765 @default.
• W4381929713 cites W3033363134 @default.
• W4381929713 cites W3040205736 @default.
• W4381929713 cites W3047880178 @default.
• W4381929713 cites W3080819661 @default.
• W4381929713 cites W3081389914 @default.
• W4381929713 cites W3083424448 @default.
• W4381929713 cites W3088839942 @default.
• W4381929713 cites W3089858402 @default.
• W4381929713 cites W3093789911 @default.
• W4381929713 cites W3108943464 @default.
• W4381929713 cites W3112637330 @default.
• W4381929713 cites W3117267883 @default.
• W4381929713 cites W3130964932 @default.
• W4381929713 cites W3142193354 @default.
• W4381929713 cites W3150010507 @default.
• W4381929713 cites W3175817142 @default.
• W4381929713 cites W3179390030 @default.
• W4381929713 cites W3199868674 @default.
• W4381929713 cites W3201477552 @default.
• W4381929713 cites W3207722453 @default.
• W4381929713 cites W3209401229 @default.
• W4381929713 cites W3214911904 @default.
• W4381929713 cites W4200418021 @default.
• W4381929713 cites W4206091204 @default.
• W4381929713 cites W4210681940 @default.
• W4381929713 cites W4213157591 @default.
• W4381929713 cites W4213211303 @default.
• W4381929713 cites W4225713221 @default.
• W4381929713 cites W4226349976 @default.
• W4381929713 cites W4283156351 @default.
• W4381929713 cites W4295787964 @default.
• W4381929713 cites W4311488300 @default.
• W4381929713 cites W4318485191 @default.
• W4381929713 doi "https://doi.org/10.3389/fped.2023.1177048" @default.
• W4381929713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37425266" @default.
• W4381929713 hasPublicationYear "2023" @default.
• W4381929713 type Work @default.
• W4381929713 citedByCount "0" @default.
• W4381929713 crossrefType "journal-article" @default.
• W4381929713 hasAuthorship W4381929713A5011315216 @default.
• W4381929713 hasAuthorship W4381929713A5019729863 @default.
• W4381929713 hasAuthorship W4381929713A5033552715 @default.
• W4381929713 hasAuthorship W4381929713A5063658652 @default.
• W4381929713 hasAuthorship W4381929713A5066034005 @default.
• W4381929713 hasAuthorship W4381929713A5067177144 @default.
• W4381929713 hasAuthorship W4381929713A5068141892 @default.
• W4381929713 hasAuthorship W4381929713A5074348958 @default.
• W4381929713 hasAuthorship W4381929713A5076825767 @default.
• W4381929713 hasAuthorship W4381929713A5089858754 @default.
• W4381929713 hasBestOaLocation W43819297131 @default.
• W4381929713 hasConcept C126322002 @default.
• W4381929713 hasConcept C185592680 @default.
• W4381929713 hasConcept C203014093 @default.
• W4381929713 hasConcept C2776376844 @default.
• W4381929713 hasConcept C2777761686 @default.
• W4381929713 hasConcept C2777901627 @default.
• W4381929713 hasConcept C2778248108 @default.
• W4381929713 hasConcept C2781184567 @default.
• W4381929713 hasConcept C2781197716 @default.
• W4381929713 hasConcept C30036603 @default.
• W4381929713 hasConcept C55493867 @default.
• W4381929713 hasConcept C71924100 @default.
• W4381929713 hasConceptScore W4381929713C126322002 @default.
• W4381929713 hasConceptScore W4381929713C185592680 @default.
• W4381929713 hasConceptScore W4381929713C203014093 @default.
• W4381929713 hasConceptScore W4381929713C2776376844 @default.
• W4381929713 hasConceptScore W4381929713C2777761686 @default.
• W4381929713 hasConceptScore W4381929713C2777901627 @default.
• W4381929713 hasConceptScore W4381929713C2778248108 @default.
• W4381929713 hasConceptScore W4381929713C2781184567 @default.
• W4381929713 hasConceptScore W4381929713C2781197716 @default.
• W4381929713 hasConceptScore W4381929713C30036603 @default.
• W4381929713 hasConceptScore W4381929713C55493867 @default.
• W4381929713 hasConceptScore W4381929713C71924100 @default.
• W4381929713 hasFunder F4320337338 @default.
• W4381929713 hasFunder F4320337354 @default.
• W4381929713 hasFunder F4320337364 @default.
• W4381929713 hasLocation W43819297131 @default.

• next