Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381930379> ?p ?o ?g. }
- W4381930379 abstract "In the course of the screening of plants from Niger for antiprotozoal activity, the methanol extract of Cassia sieberiana , and the dichloromethane extracts of Ziziphus mauritiana and Sesamun alatum were found to be active against protozoan parasites, namely Trypanosoma brucei rhodesiense , Trypanosoma cruzi , Leishmania donovani and/or Plasmodium falciparum . Myricitrin ( 1 ), quercitrin ( 2 ) and 1-palmitoyl-lysolecithin ( 3 ) were isolated from C. sieberiana . From Z. mauritiana , the three triterpene derivatives 13 , 15 , and 16 are described here for the first time. Their chemical structures were determined by 1D and 2D NMR experiments, UV, IR and HRESIMS data. The absolute configurations were assigned via comparison of the experimental and calculated ECD spectra. In addition, eight known cyclopeptide alkaloids ( 4 , 5 , 7 – 12 ), and five known triterpenoids ( 6 , 14 , 17–19 ) were isolated. The antiprotozoal activity of the isolated compounds, as well as of eleven quinone derivatives ( 20–30 ) previously isolated from S. alatum was determined in vitro. The cytotoxicity in L6 rat myoblast cells was also evaluated. Compound 18 showed the highest antiplasmodial activity (IC 50 = 0.2 µm) and compound 24 inhibited T. b. rhodesiense with an IC 50 value of 0.007 µ M. However, it also displayed significant cytotoxicity in L6 cells (IC 50 = 0.4 µm)." @default.
- W4381930379 created "2023-06-25" @default.
- W4381930379 creator A5010850019 @default.
- W4381930379 creator A5012139965 @default.
- W4381930379 creator A5016053202 @default.
- W4381930379 creator A5022895918 @default.
- W4381930379 creator A5032276052 @default.
- W4381930379 creator A5035641019 @default.
- W4381930379 creator A5084090049 @default.
- W4381930379 creator A5084123396 @default.
- W4381930379 creator A5085582414 @default.
- W4381930379 date "2023-06-23" @default.
- W4381930379 modified "2023-09-25" @default.
- W4381930379 title "Antiprotozoal activity of natural products from Nigerien plants used in folk medicine" @default.
- W4381930379 cites W1087878786 @default.
- W4381930379 cites W1604596395 @default.
- W4381930379 cites W1634324966 @default.
- W4381930379 cites W1965291586 @default.
- W4381930379 cites W1967406119 @default.
- W4381930379 cites W1968390188 @default.
- W4381930379 cites W1982080107 @default.
- W4381930379 cites W1982116813 @default.
- W4381930379 cites W1988299739 @default.
- W4381930379 cites W1993713669 @default.
- W4381930379 cites W1997967098 @default.
- W4381930379 cites W2000600053 @default.
- W4381930379 cites W2000881860 @default.
- W4381930379 cites W2001685835 @default.
- W4381930379 cites W2012934900 @default.
- W4381930379 cites W2016847274 @default.
- W4381930379 cites W2020088487 @default.
- W4381930379 cites W2048429707 @default.
- W4381930379 cites W2060323430 @default.
- W4381930379 cites W2065029529 @default.
- W4381930379 cites W2067349986 @default.
- W4381930379 cites W2071134391 @default.
- W4381930379 cites W2082861607 @default.
- W4381930379 cites W2105523385 @default.
- W4381930379 cites W2121128070 @default.
- W4381930379 cites W2125105740 @default.
- W4381930379 cites W2126420606 @default.
- W4381930379 cites W2151438517 @default.
- W4381930379 cites W2201091886 @default.
- W4381930379 cites W2323822169 @default.
- W4381930379 cites W2335658487 @default.
- W4381930379 cites W2395384671 @default.
- W4381930379 cites W2519702121 @default.
- W4381930379 cites W2585943218 @default.
- W4381930379 cites W2767574288 @default.
- W4381930379 cites W2774482550 @default.
- W4381930379 cites W2807507381 @default.
- W4381930379 cites W2886499486 @default.
- W4381930379 cites W2901924484 @default.
- W4381930379 cites W2981583610 @default.
- W4381930379 cites W2983109795 @default.
- W4381930379 cites W3129386044 @default.
- W4381930379 cites W4205265340 @default.
- W4381930379 cites W4224310790 @default.
- W4381930379 cites W4312181986 @default.
- W4381930379 doi "https://doi.org/10.3389/fphar.2023.1190241" @default.
- W4381930379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37426806" @default.
- W4381930379 hasPublicationYear "2023" @default.
- W4381930379 type Work @default.
- W4381930379 citedByCount "0" @default.
- W4381930379 crossrefType "journal-article" @default.
- W4381930379 hasAuthorship W4381930379A5010850019 @default.
- W4381930379 hasAuthorship W4381930379A5012139965 @default.
- W4381930379 hasAuthorship W4381930379A5016053202 @default.
- W4381930379 hasAuthorship W4381930379A5022895918 @default.
- W4381930379 hasAuthorship W4381930379A5032276052 @default.
- W4381930379 hasAuthorship W4381930379A5035641019 @default.
- W4381930379 hasAuthorship W4381930379A5084090049 @default.
- W4381930379 hasAuthorship W4381930379A5084123396 @default.
- W4381930379 hasAuthorship W4381930379A5085582414 @default.
- W4381930379 hasBestOaLocation W43819303791 @default.
- W4381930379 hasConcept C104317684 @default.
- W4381930379 hasConcept C109316439 @default.
- W4381930379 hasConcept C136764020 @default.
- W4381930379 hasConcept C142724271 @default.
- W4381930379 hasConcept C185592680 @default.
- W4381930379 hasConcept C202751555 @default.
- W4381930379 hasConcept C203014093 @default.
- W4381930379 hasConcept C206103511 @default.
- W4381930379 hasConcept C2776171842 @default.
- W4381930379 hasConcept C2776555147 @default.
- W4381930379 hasConcept C2776635100 @default.
- W4381930379 hasConcept C2777625466 @default.
- W4381930379 hasConcept C2778689377 @default.
- W4381930379 hasConcept C2779502636 @default.
- W4381930379 hasConcept C2780867653 @default.
- W4381930379 hasConcept C2781333301 @default.
- W4381930379 hasConcept C2781421772 @default.
- W4381930379 hasConcept C2909346784 @default.
- W4381930379 hasConcept C41008148 @default.
- W4381930379 hasConcept C55493867 @default.
- W4381930379 hasConcept C556039675 @default.
- W4381930379 hasConcept C59822182 @default.
- W4381930379 hasConcept C71240020 @default.
- W4381930379 hasConcept C71924100 @default.
- W4381930379 hasConcept C71928629 @default.