Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381930863> ?p ?o ?g. }
- W4381930863 endingPage "102787" @default.
- W4381930863 startingPage "102787" @default.
- W4381930863 abstract "Irisin is a newly discovered myokine which links exercise to inflammation and inflammation-related diseases through macrophage regulation. However, the effect of irisin on the activity of inflammation related immune cells (such as neutrophils) has not been clearly described. The objective of our study was to explore the effect of irisin on the neutrophil extracellular traps (NETs) formation. Phorbol-12-myristate-13-acetate (PMA) was used to construct a classic neutrophil inflammation model that was used to observe the formation of NETs in vitro. We studied the effect of irisin on NETs formation and its regulation mechanism. Subsequently, acute pancreatitis (AP) was used to verify the protective effect of irisin in vivo, which was an acute aseptic inflammatory response disease model closely related to NETs. Our study found that addition of irisin significantly reduced the formation of NETs via regulation of the P38/MAPK pathway through integrin αVβ5, which might be the one of key pathways in NETs formation, and which could theoretically offset the immunoregulatory effect of irisin. Systemic treatment with irisin reduced the severity of tissue damage common in the disease and inhibited the formation of NETs in pancreatic necrotic tissue of two classical AP mouse models. The findings confirmed for the first time that irisin could inhibit NETs formation and protect mice from pancreatic injury, which further elucidated the protective effect of exercise on acute inflammatory injury." @default.
- W4381930863 created "2023-06-25" @default.
- W4381930863 creator A5001807969 @default.
- W4381930863 creator A5001853423 @default.
- W4381930863 creator A5019238809 @default.
- W4381930863 creator A5030866090 @default.
- W4381930863 creator A5036883662 @default.
- W4381930863 creator A5038170144 @default.
- W4381930863 creator A5042591178 @default.
- W4381930863 creator A5055625705 @default.
- W4381930863 creator A5056534747 @default.
- W4381930863 creator A5074732881 @default.
- W4381930863 creator A5075930842 @default.
- W4381930863 creator A5077440225 @default.
- W4381930863 creator A5089812245 @default.
- W4381930863 date "2023-08-01" @default.
- W4381930863 modified "2023-10-18" @default.
- W4381930863 title "Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice" @default.
- W4381930863 cites W1578284790 @default.
- W4381930863 cites W1600560134 @default.
- W4381930863 cites W1822135553 @default.
- W4381930863 cites W1869061972 @default.
- W4381930863 cites W19101126 @default.
- W4381930863 cites W2004070141 @default.
- W4381930863 cites W2009571354 @default.
- W4381930863 cites W2014776493 @default.
- W4381930863 cites W2031474938 @default.
- W4381930863 cites W2043265447 @default.
- W4381930863 cites W2044045006 @default.
- W4381930863 cites W2049676951 @default.
- W4381930863 cites W2104934425 @default.
- W4381930863 cites W2121134187 @default.
- W4381930863 cites W2141783082 @default.
- W4381930863 cites W2156293127 @default.
- W4381930863 cites W2235165689 @default.
- W4381930863 cites W2261479737 @default.
- W4381930863 cites W2588296676 @default.
- W4381930863 cites W2600882296 @default.
- W4381930863 cites W2601150704 @default.
- W4381930863 cites W2606375388 @default.
- W4381930863 cites W2768317241 @default.
- W4381930863 cites W2785530199 @default.
- W4381930863 cites W2790943882 @default.
- W4381930863 cites W2800031275 @default.
- W4381930863 cites W2800328649 @default.
- W4381930863 cites W2811115492 @default.
- W4381930863 cites W2885986504 @default.
- W4381930863 cites W2891400614 @default.
- W4381930863 cites W2911942299 @default.
- W4381930863 cites W2925230746 @default.
- W4381930863 cites W2955771536 @default.
- W4381930863 cites W2984551404 @default.
- W4381930863 cites W2992068102 @default.
- W4381930863 cites W3040124259 @default.
- W4381930863 cites W3047659763 @default.
- W4381930863 cites W3120670329 @default.
- W4381930863 cites W3134306191 @default.
- W4381930863 cites W3135348615 @default.
- W4381930863 cites W4211022384 @default.
- W4381930863 cites W4223588309 @default.
- W4381930863 doi "https://doi.org/10.1016/j.redox.2023.102787" @default.
- W4381930863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37392517" @default.
- W4381930863 hasPublicationYear "2023" @default.
- W4381930863 type Work @default.
- W4381930863 citedByCount "1" @default.
- W4381930863 countsByYear W43819308632023 @default.
- W4381930863 crossrefType "journal-article" @default.
- W4381930863 hasAuthorship W4381930863A5001807969 @default.
- W4381930863 hasAuthorship W4381930863A5001853423 @default.
- W4381930863 hasAuthorship W4381930863A5019238809 @default.
- W4381930863 hasAuthorship W4381930863A5030866090 @default.
- W4381930863 hasAuthorship W4381930863A5036883662 @default.
- W4381930863 hasAuthorship W4381930863A5038170144 @default.
- W4381930863 hasAuthorship W4381930863A5042591178 @default.
- W4381930863 hasAuthorship W4381930863A5055625705 @default.
- W4381930863 hasAuthorship W4381930863A5056534747 @default.
- W4381930863 hasAuthorship W4381930863A5074732881 @default.
- W4381930863 hasAuthorship W4381930863A5075930842 @default.
- W4381930863 hasAuthorship W4381930863A5077440225 @default.
- W4381930863 hasAuthorship W4381930863A5089812245 @default.
- W4381930863 hasBestOaLocation W43819308631 @default.
- W4381930863 hasConcept C117365660 @default.
- W4381930863 hasConcept C126322002 @default.
- W4381930863 hasConcept C134018914 @default.
- W4381930863 hasConcept C134897094 @default.
- W4381930863 hasConcept C185592680 @default.
- W4381930863 hasConcept C203014093 @default.
- W4381930863 hasConcept C2776670229 @default.
- W4381930863 hasConcept C2776914184 @default.
- W4381930863 hasConcept C2779959927 @default.
- W4381930863 hasConcept C51551487 @default.
- W4381930863 hasConcept C57074206 @default.
- W4381930863 hasConcept C62478195 @default.
- W4381930863 hasConcept C71924100 @default.
- W4381930863 hasConcept C86803240 @default.
- W4381930863 hasConcept C95444343 @default.
- W4381930863 hasConceptScore W4381930863C117365660 @default.
- W4381930863 hasConceptScore W4381930863C126322002 @default.