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- W4381948765 abstract "The Lead-DBS imaging toolbox reconstructs the location of β-oscillations in the subthalamic nucleus (STN) in patients with Parkinson’s disease. The objective was to compare this probabilistic location with those of intraoperative monopolar β-oscillations (Vercise Cartesia directional electrodes, Boston Scientific). Also, the efficacy of stimulated structures in reducing motor symptoms were analysed. β-oscillations were computed from local field potentials [0.5-3kHz] by using shielded wires for monopolar recordings with an extracranial shielded reference. For each electrode contact, power spectral densities of the β-band [13-31Hz] were compared with those of all eight electrode contacts. The DISTAL, electrophysiological, and DBS target atlases of the Lead-DBS toolbox were applied to the reconstructed electrodes from preoperative MRI and postoperative CT. Thirty-six electrodes (20 patients: 7 female, 13 male; 16/20 both, 4/20 single STN) were analysed. Stimulation sites dorsal and/or lateral to the sensorimotor STN were most efficient. In 33/36 electrodes at least one contact was measured with stronger β-oscillations, 23 in or touching the ventral subpart of the probabilistic volume with β-oscillations, 10 not located in or touching but adjacent to this volume; in 3/36 electrodes, no contact was found with β-oscillations, they were distant from this volume. Monopolar local field potentials confirmed the ventral subpart of the probabilistic β-oscillations." @default.
- W4381948765 created "2023-06-26" @default.
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- W4381948765 date "2023-06-23" @default.
- W4381948765 modified "2023-09-23" @default.
- W4381948765 title "Validation of Lead-DBS β-oscillation Localization with Directional Electrodes" @default.
- W4381948765 doi "https://doi.org/10.20944/preprints202306.1675.v1" @default.
- W4381948765 hasPublicationYear "2023" @default.
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