Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381949231> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4381949231 endingPage "863" @default.
- W4381949231 startingPage "848" @default.
- W4381949231 abstract "The lack of effective conventional therapies against dengue has created an interest in herbal preparations as alternative therapies. In the present study, in vitroeffects of Cordia curassavicaessential oil (EO) on both dengue virus replication and cytokine production were examined. Predictions ofmolecular interactions between EO compounds and virus and cell proteins were performed with AutoDock Vina. The EO inhibited replication of dengue virus serotypes at IC50< 30 μg/mL, and it reduced 87% TNF-α, 67% IL-8 and 46% IFN-α in LPS-stimulated PBMCs.The main EO compounds were trans-β-caryophyllene (21.4%), germacrene D (17.8%), α-copaene (16.5%), trans-β-guaiene (8.2%), and α-pinene (6.0%). The first two compounds, δ-cadinene, α-muurolene, α-cubebene and β-burbonene were coupled to proteins involved in the TLR-4 cytokine effector pathway. 3,7-Guaiadiene was coupled to the viral E and C proteins. This study demonstrates the potential of C. curassavicaEO as a starting point for discovering novel therapeutic for dengue." @default.
- W4381949231 created "2023-06-26" @default.
- W4381949231 creator A5005172693 @default.
- W4381949231 creator A5022224090 @default.
- W4381949231 creator A5025935450 @default.
- W4381949231 creator A5037285612 @default.
- W4381949231 creator A5079452020 @default.
- W4381949231 creator A5089149293 @default.
- W4381949231 date "2023-11-30" @default.
- W4381949231 modified "2023-09-27" @default.
- W4381949231 title "Essential oil of Cordia curassavica(Jacq) Roem. & Schult: in vitroand in silicoevaluation of effects on dengue virus replication and cytokines production" @default.
- W4381949231 doi "https://doi.org/10.37360/blacpma.23.22.6.57" @default.
- W4381949231 hasPublicationYear "2023" @default.
- W4381949231 type Work @default.
- W4381949231 citedByCount "0" @default.
- W4381949231 crossrefType "journal-article" @default.
- W4381949231 hasAuthorship W4381949231A5005172693 @default.
- W4381949231 hasAuthorship W4381949231A5022224090 @default.
- W4381949231 hasAuthorship W4381949231A5025935450 @default.
- W4381949231 hasAuthorship W4381949231A5037285612 @default.
- W4381949231 hasAuthorship W4381949231A5079452020 @default.
- W4381949231 hasAuthorship W4381949231A5089149293 @default.
- W4381949231 hasBestOaLocation W43819492311 @default.
- W4381949231 hasConcept C140704245 @default.
- W4381949231 hasConcept C159047783 @default.
- W4381949231 hasConcept C185592680 @default.
- W4381949231 hasConcept C203014093 @default.
- W4381949231 hasConcept C2522874641 @default.
- W4381949231 hasConcept C2777278459 @default.
- W4381949231 hasConcept C2778004101 @default.
- W4381949231 hasConcept C2778690821 @default.
- W4381949231 hasConcept C2779635636 @default.
- W4381949231 hasConcept C533803919 @default.
- W4381949231 hasConcept C55493867 @default.
- W4381949231 hasConcept C556039675 @default.
- W4381949231 hasConcept C59822182 @default.
- W4381949231 hasConcept C70899900 @default.
- W4381949231 hasConcept C71924100 @default.
- W4381949231 hasConcept C86803240 @default.
- W4381949231 hasConceptScore W4381949231C140704245 @default.
- W4381949231 hasConceptScore W4381949231C159047783 @default.
- W4381949231 hasConceptScore W4381949231C185592680 @default.
- W4381949231 hasConceptScore W4381949231C203014093 @default.
- W4381949231 hasConceptScore W4381949231C2522874641 @default.
- W4381949231 hasConceptScore W4381949231C2777278459 @default.
- W4381949231 hasConceptScore W4381949231C2778004101 @default.
- W4381949231 hasConceptScore W4381949231C2778690821 @default.
- W4381949231 hasConceptScore W4381949231C2779635636 @default.
- W4381949231 hasConceptScore W4381949231C533803919 @default.
- W4381949231 hasConceptScore W4381949231C55493867 @default.
- W4381949231 hasConceptScore W4381949231C556039675 @default.
- W4381949231 hasConceptScore W4381949231C59822182 @default.
- W4381949231 hasConceptScore W4381949231C70899900 @default.
- W4381949231 hasConceptScore W4381949231C71924100 @default.
- W4381949231 hasConceptScore W4381949231C86803240 @default.
- W4381949231 hasIssue "6" @default.
- W4381949231 hasLocation W43819492311 @default.
- W4381949231 hasOpenAccess W4381949231 @default.
- W4381949231 hasPrimaryLocation W43819492311 @default.
- W4381949231 hasRelatedWork W1751219545 @default.
- W4381949231 hasRelatedWork W2049763445 @default.
- W4381949231 hasRelatedWork W2076100628 @default.
- W4381949231 hasRelatedWork W2080259596 @default.
- W4381949231 hasRelatedWork W2096105915 @default.
- W4381949231 hasRelatedWork W2100364502 @default.
- W4381949231 hasRelatedWork W2108939276 @default.
- W4381949231 hasRelatedWork W2124479668 @default.
- W4381949231 hasRelatedWork W2580307449 @default.
- W4381949231 hasRelatedWork W3204874602 @default.
- W4381949231 hasVolume "22" @default.
- W4381949231 isParatext "false" @default.
- W4381949231 isRetracted "false" @default.
- W4381949231 workType "article" @default.