Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381951388> ?p ?o ?g. }
- W4381951388 abstract "ABSTRACT Host resistance to a common protozoan parasite Toxoplasma gondii relies on a coordinated immune response involving multiple cell types, including macrophages. Embryonically seeded tissue-resident macrophages (TRMs) play a critical role in maintaining tissue homeostasis but their role in parasite clearance is poorly understood. In this study, we uncovered a crucial aspect of host defense against T. gondii mediated by TRMs. Through the use of neutralizing antibodies and conditional IFN-γ receptor-deficient mice, we demonstrated that IFN-γ directly mediated the elimination of TRMs. Mechanistically, IFN-γ stimulation rendered macrophages unresponsive to macrophage colony-stimulating factor (M-CSF) and inactivated mTOR signaling by causing the shedding of CD115 (CSFR1), the receptor for M-CSF. Further experiments revealed the essential role of macrophage IFN-γ responsiveness in host resistance to T. gondii. The elimination of peritoneal TRMs emerged as a host defense mechanism aimed at limiting the parasite’s reservoir. The identified mechanism, involving IFN-γ-induced CD115 and mTOR-dependent cell death, provides insights into the adaptation of macrophage subsets during infection and highlights a crucial aspect of host defense against intracellular pathogens." @default.
- W4381951388 created "2023-06-26" @default.
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- W4381951388 date "2023-06-25" @default.
- W4381951388 modified "2023-09-27" @default.
- W4381951388 title "Parasite-Induced IFN-γ Regulates Host Defense via CD115 and mTOR-Dependent Mechanism of Tissue-Resident Macrophage Death" @default.
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- W4381951388 doi "https://doi.org/10.1101/2023.06.23.546211" @default.
- W4381951388 hasPublicationYear "2023" @default.
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