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• W4381952290 endingPage "101035" @default.
• W4381952290 startingPage "101035" @default.
• W4381952290 abstract "This review aimed to summarise evidence about the impact of pharmacological and non-pharmacological interventions on survival in COPD patients. We performed a narrative literature review on the effect of pharmacological and non-pharmacological interventions on survival in COPD patients. Inhaled therapies are central to reduce symptoms in COPD. In particular, inhaled steroids seem to have the greatest effect on mortality. Despite the anti-inflammatory effects attributed to statins, their benefit in COPD has been shown only in cases of combined cardiovascular diseases. The use of beta-blockers in COPD has not been associated with increased COPD-related mortality and a beneficial effect on all-cause mortality has even been shown in COPD patients with cardiovascular diseases. Influenza and pneumococcal vaccination reduced the occurrence of exacerbations and mortality due to COPD. In addition, long-term oxygen therapy (LTOT) (≥15h/day) in COPD patients with severe hypoxemia had a positive effect on survival. Regarding non-pharmacological interventions, it has been demonstrated that smoking cessation, treatment compliance and nutritional supplementation for underweight patients also have a positive effect on survival. Non-invasive ventilation results were dependent on patient PaCO2 levels. In patients with advanced COPD, further prospective studies are needed to know the effect of bronchoscopic lung volume reduction and lung transplant on COPD survival. Regarding lung transplant, a survival benefit in patients with a pre-transplant BODE score of ≥7 has been shown in retrospective studies. Most of the studies did not evaluate survival as the main criteria and further long-term studies on the global management of COPD are required." @default.
• W4381952290 created "2023-06-26" @default.
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• W4381952290 creator A5083251348 @default.
• W4381952290 date "2023-11-01" @default.
• W4381952290 modified "2023-10-03" @default.
• W4381952290 title "Impact of pharmacological and non-pharmacological interventions on mortality in chronic obstructive pulmonary disease (COPD) patients" @default.
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• W4381952290 doi "https://doi.org/10.1016/j.resmer.2023.101035" @default.
• W4381952290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37651981" @default.
• W4381952290 hasPublicationYear "2023" @default.
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