Matches in SemOpenAlex for { <https://semopenalex.org/work/W4381953139> ?p ?o ?g. }
- W4381953139 endingPage "144400" @default.
- W4381953139 startingPage "144400" @default.
- W4381953139 abstract "Metal-organic frameworks (MOFs) are a novel class of crystalline porous materials, consisting of metal ions and organic linkers. These hybrid materials possess exceptional porosity and specific surface area, which have recently garnered significant interest due to their potential applications in gas separation and storage, energy storage, biomedical imaging, and drug delivery. As MOFs are being explored for biomedical applications, it is essential to comprehensively assess their toxicity. Although nearly ninety thousand MOFs have been investigated, evaluating and optimizing their physico-chemical properties in relevant biological systems remain critical for their clinical translation. In this review article, we first provide a brief classification of MOFs based on their chemical structures. We then conduct a comprehensive evaluation of in vitro and in vivo studies that assess the biocompatibility of MOFs. Additionally, we discuss various approaches to mitigate the critical factors associated with MOF toxicity. To this end, the effects of chemistry, particle size, morphology, and particle aggregation are examined. To better understand MOFs' potential toxicity to living organisms, we also delve into the toxicity mechanisms of nanoparticles (NPs). Furthermore, we introduce and evaluate strategies such as surface modification to reduce the inherent toxicity of MOFs. Finally, we discuss current challenges, the path to clinical trials, and new research directions." @default.
- W4381953139 created "2023-06-26" @default.
- W4381953139 creator A5001001125 @default.
- W4381953139 creator A5007028844 @default.
- W4381953139 creator A5076294682 @default.
- W4381953139 creator A5080290886 @default.
- W4381953139 creator A5080365197 @default.
- W4381953139 date "2023-09-01" @default.
- W4381953139 modified "2023-10-15" @default.
- W4381953139 title "Mitigating metal-organic framework (MOF) toxicity for biomedical applications" @default.
- W4381953139 cites W1677747913 @default.
- W4381953139 cites W1762545184 @default.
- W4381953139 cites W1867547547 @default.
- W4381953139 cites W1978954246 @default.
- W4381953139 cites W1984753398 @default.
- W4381953139 cites W1987186905 @default.
- W4381953139 cites W1989722183 @default.
- W4381953139 cites W2000379890 @default.
- W4381953139 cites W2017912998 @default.
- W4381953139 cites W2027834183 @default.
- W4381953139 cites W2041270553 @default.
- W4381953139 cites W2041368761 @default.
- W4381953139 cites W2054997209 @default.
- W4381953139 cites W2064405498 @default.
- W4381953139 cites W2080733627 @default.
- W4381953139 cites W2084063536 @default.
- W4381953139 cites W2094986951 @default.
- W4381953139 cites W2103229089 @default.
- W4381953139 cites W2105761150 @default.
- W4381953139 cites W2120078902 @default.
- W4381953139 cites W2126846737 @default.
- W4381953139 cites W2129735227 @default.
- W4381953139 cites W2135465393 @default.
- W4381953139 cites W2138574167 @default.
- W4381953139 cites W2141939342 @default.
- W4381953139 cites W2147710759 @default.
- W4381953139 cites W2166828161 @default.
- W4381953139 cites W2229332918 @default.
- W4381953139 cites W2298537182 @default.
- W4381953139 cites W2326895271 @default.
- W4381953139 cites W2438694947 @default.
- W4381953139 cites W2531259979 @default.
- W4381953139 cites W2553696468 @default.
- W4381953139 cites W2594317240 @default.
- W4381953139 cites W2608941817 @default.
- W4381953139 cites W2786119245 @default.
- W4381953139 cites W2793824718 @default.
- W4381953139 cites W2794046203 @default.
- W4381953139 cites W2794203233 @default.
- W4381953139 cites W2805982534 @default.
- W4381953139 cites W2888184188 @default.
- W4381953139 cites W2901774267 @default.
- W4381953139 cites W2920443714 @default.
- W4381953139 cites W2922408224 @default.
- W4381953139 cites W2944995286 @default.
- W4381953139 cites W2964660076 @default.
- W4381953139 cites W2964933170 @default.
- W4381953139 cites W3000336454 @default.
- W4381953139 cites W3001055318 @default.
- W4381953139 cites W3004060960 @default.
- W4381953139 cites W3010747828 @default.
- W4381953139 cites W3011479803 @default.
- W4381953139 cites W3018182959 @default.
- W4381953139 cites W3036828620 @default.
- W4381953139 cites W3048908832 @default.
- W4381953139 cites W3048976449 @default.
- W4381953139 cites W3049430787 @default.
- W4381953139 cites W3081718800 @default.
- W4381953139 cites W3084054617 @default.
- W4381953139 cites W3088965891 @default.
- W4381953139 cites W3093344513 @default.
- W4381953139 cites W3094778884 @default.
- W4381953139 cites W3096743843 @default.
- W4381953139 cites W3097770873 @default.
- W4381953139 cites W3100669944 @default.
- W4381953139 cites W3110926367 @default.
- W4381953139 cites W3123035107 @default.
- W4381953139 cites W3126041711 @default.
- W4381953139 cites W3127807986 @default.
- W4381953139 cites W3137094874 @default.
- W4381953139 cites W3152047692 @default.
- W4381953139 cites W3161467378 @default.
- W4381953139 cites W3161728961 @default.
- W4381953139 cites W3163738557 @default.
- W4381953139 cites W3176093553 @default.
- W4381953139 cites W3182903427 @default.
- W4381953139 cites W3194729348 @default.
- W4381953139 cites W3194982782 @default.
- W4381953139 cites W3199466626 @default.
- W4381953139 cites W3200925360 @default.
- W4381953139 cites W3202545629 @default.
- W4381953139 cites W3209511263 @default.
- W4381953139 cites W3210416416 @default.
- W4381953139 cites W3212010726 @default.
- W4381953139 cites W3214743823 @default.
- W4381953139 cites W3217588757 @default.
- W4381953139 cites W4206501868 @default.
- W4381953139 cites W4206597312 @default.