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- W4381954956 abstract "Our body sites are colonized by microbes that have different types of interactions with our organs. In the past decades, the complex interactions between the host and the microbiome are being deciphered, due to the development of molecular tools and techniques, such as metagenomics, metabolomics, lipidomics, and metatranscriptomics. Microbiome, as an invisible “organ that inhabits a particular environment and especially the collection of microorganisms living in or on the human body.” “Normal” microbiome is described as a microbial community with high diversity, good balance, and normal functions in host-microbial interactions for immunity, barriers, nutrients, and metabolism. In this chapter, we discuss the definition of “normal” microbiome, methods to study/quantify microbiome, and potential strategies to restore its healthy status in human diseases. The contribution of the microbiome to homeostatic regulation extends beyond the gut to almost all organs, e.g., eyes, in the human body. Thus, microbiome definition and functions have location and organ specificity. We also outline the challenges in the field and future directions for functional studies, physiological relevance, host-microbial interactions, and metabolites. Insights into healthy microbiomes will help us to develop new strategies to maintain healthy status and prevent/treat diseases." @default.
- W4381954956 created "2023-06-26" @default.
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- W4381954956 date "2023-01-01" @default.
- W4381954956 modified "2023-09-27" @default.
- W4381954956 title "The “normal” gut microbiome and human health" @default.
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- W4381954956 doi "https://doi.org/10.1016/b978-0-323-98338-9.00001-3" @default.
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