Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382010513> ?p ?o ?g. }
- W4382010513 abstract "Bisphenol S (BPS) is a novel bisphenol A (BPA) analogue, a ubiquitous environmental pollutant that disrupts male reproductive system. Whether BPS affects Leydig cell maturation in male puberty remains unclear. Male Sprague–Dawley rats (age of 35 days) were daily gavaged to 0, 1, 10, 100, and 200 mg/kg/day from postnatal days 35–56. BPS at 1–10 mg/kg/day and higher doses markedly reduced serum testosterone and progesterone levels but it at 200 mg/kg/day significantly increased estradiol level. BPS at 100 and 200 mg/kg/day significantly elevated serum luteinizing hormone (LH) levels. BPS at 1–10 mg/kg/day and higher doses significantly reduced inhibin A and inhibin B levels. BPS at 100 and 200 mg/kg/day markedly increased CYP11A1+ Leydig cell number, but did not affect HSD11B1+ (a mature Leydig cell marker) cell number. BPS at 10 mg/kg/day and higher doses significantly downregulated the expression of Cyp11a1 and at 100 and 200 mg/kg/d significantly lowered Cyp17a1, Hsd11b1, and Nr5a1 in the testes. BPS at 100 and/or 200 mg/kg/day significantly elevated Lhb in the pituitary. BPS at 100 and 200 mg/kg/day significantly increased the phosphorylation of AKT1, AKT2, and CREB without affecting total AKT1, AKT2, and CREB levels. BPS at 1–100 μM significantly suppressed testosterone production and induced proliferation of primary immature Leydig cells after 24 h of treatment and these actions were reversed by estrogen receptor α antagonist, ICI 182780, and partially reversed by vitamin E. BPS at 0.1–10 μM significantly increased oxidative stress of Leydig cells in vitro. BPS also directly inhibited 17β-hydroxysteroid dehydrogenase 3 activity at 10–100 μM. In conclusion, BPS causes hypergonadotropic androgen deficiency in male rats during pubertal exposure via activating ESR1 and inducing ROS in immature Leydig cells and directly inhibiting 17β-hydroxysteroid dehydrogenase 3 activity." @default.
- W4382010513 created "2023-06-27" @default.
- W4382010513 creator A5002627636 @default.
- W4382010513 creator A5005066593 @default.
- W4382010513 creator A5009921747 @default.
- W4382010513 creator A5014945281 @default.
- W4382010513 creator A5024090220 @default.
- W4382010513 creator A5027516492 @default.
- W4382010513 creator A5030269921 @default.
- W4382010513 creator A5037458478 @default.
- W4382010513 creator A5040406694 @default.
- W4382010513 creator A5054993481 @default.
- W4382010513 creator A5062193442 @default.
- W4382010513 creator A5066862028 @default.
- W4382010513 creator A5068517442 @default.
- W4382010513 creator A5091243949 @default.
- W4382010513 date "2023-06-26" @default.
- W4382010513 modified "2023-10-17" @default.
- W4382010513 title "Bisphenol S stimulates Leydig cell proliferation but inhibits differentiation in pubertal male rats through multiple mechanisms" @default.
- W4382010513 cites W1526525763 @default.
- W4382010513 cites W1965891907 @default.
- W4382010513 cites W1967203069 @default.
- W4382010513 cites W1974367155 @default.
- W4382010513 cites W1978761842 @default.
- W4382010513 cites W1980416742 @default.
- W4382010513 cites W1982788880 @default.
- W4382010513 cites W1983300755 @default.
- W4382010513 cites W1988246318 @default.
- W4382010513 cites W1989461872 @default.
- W4382010513 cites W1994990062 @default.
- W4382010513 cites W2006104250 @default.
- W4382010513 cites W2007232450 @default.
- W4382010513 cites W2013082510 @default.
- W4382010513 cites W2025811822 @default.
- W4382010513 cites W2028728873 @default.
- W4382010513 cites W2033124168 @default.
- W4382010513 cites W2033873142 @default.
- W4382010513 cites W2043226290 @default.
- W4382010513 cites W2045059986 @default.
- W4382010513 cites W2049577228 @default.
- W4382010513 cites W2053952619 @default.
- W4382010513 cites W2065634561 @default.
- W4382010513 cites W2080845101 @default.
- W4382010513 cites W2081044535 @default.
- W4382010513 cites W2095047112 @default.
- W4382010513 cites W2119248051 @default.
- W4382010513 cites W2138484830 @default.
- W4382010513 cites W2140167385 @default.
- W4382010513 cites W2159071962 @default.
- W4382010513 cites W2171192677 @default.
- W4382010513 cites W2328448114 @default.
- W4382010513 cites W2493863175 @default.
- W4382010513 cites W2732818952 @default.
- W4382010513 cites W2809122330 @default.
- W4382010513 cites W2885303424 @default.
- W4382010513 cites W2898903301 @default.
- W4382010513 cites W2946275766 @default.
- W4382010513 cites W2965708146 @default.
- W4382010513 cites W2983514836 @default.
- W4382010513 cites W2995121947 @default.
- W4382010513 cites W2996286278 @default.
- W4382010513 cites W2996686258 @default.
- W4382010513 cites W3046400337 @default.
- W4382010513 cites W3084496879 @default.
- W4382010513 cites W3161426911 @default.
- W4382010513 cites W4211158689 @default.
- W4382010513 doi "https://doi.org/10.1002/tox.23873" @default.
- W4382010513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37357847" @default.
- W4382010513 hasPublicationYear "2023" @default.
- W4382010513 type Work @default.
- W4382010513 citedByCount "0" @default.
- W4382010513 crossrefType "journal-article" @default.
- W4382010513 hasAuthorship W4382010513A5002627636 @default.
- W4382010513 hasAuthorship W4382010513A5005066593 @default.
- W4382010513 hasAuthorship W4382010513A5009921747 @default.
- W4382010513 hasAuthorship W4382010513A5014945281 @default.
- W4382010513 hasAuthorship W4382010513A5024090220 @default.
- W4382010513 hasAuthorship W4382010513A5027516492 @default.
- W4382010513 hasAuthorship W4382010513A5030269921 @default.
- W4382010513 hasAuthorship W4382010513A5037458478 @default.
- W4382010513 hasAuthorship W4382010513A5040406694 @default.
- W4382010513 hasAuthorship W4382010513A5054993481 @default.
- W4382010513 hasAuthorship W4382010513A5062193442 @default.
- W4382010513 hasAuthorship W4382010513A5066862028 @default.
- W4382010513 hasAuthorship W4382010513A5068517442 @default.
- W4382010513 hasAuthorship W4382010513A5091243949 @default.
- W4382010513 hasConcept C104317684 @default.
- W4382010513 hasConcept C126322002 @default.
- W4382010513 hasConcept C134018914 @default.
- W4382010513 hasConcept C1629964 @default.
- W4382010513 hasConcept C170493617 @default.
- W4382010513 hasConcept C185592680 @default.
- W4382010513 hasConcept C2776885963 @default.
- W4382010513 hasConcept C2777736315 @default.
- W4382010513 hasConcept C2778575703 @default.
- W4382010513 hasConcept C2779279991 @default.
- W4382010513 hasConcept C526171541 @default.
- W4382010513 hasConcept C55493867 @default.
- W4382010513 hasConcept C62231903 @default.
- W4382010513 hasConcept C71315377 @default.