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- W4382011134 abstract "Adult stem cells (ASCs) are pluripotent cells with the capacity to self-renew and constantly replace lost cells due to physiological turnover or injury. Understanding the molecular mechanisms of the precise coordination of stem cell proliferation and proper cell fate decision is important to regeneration and organismal homeostasis. The planarian epidermis provides a highly tractable model to study ASC complex dynamic due to the distinct spatiotemporal differentiation stages during lineage development. Here, we identified the myosin regulatory light chain (MRLC) homologue in the Dugesia japonica transcriptome. We found high expression levels of MRLC in wound region during regeneration and also expressed in late epidermal progenitors as an essential regulator of the lineage from neoblasts to mature epidermal cells. We investigated the function of MRLC using in situ hybridization, real-time polymerase chain reaction and double fluorescent and uncovered the potential mechanism. Knockdown of MRLC leads to a remarkable increase in cell death, causes severe abnormalities during regeneration and homeostasis and eventually leads to animal death. The global decrease in epidermal cell in MRLC RNAi animals induces accelerated epidermal proliferation and differentiation. Additionally, we find that MRLC is co-expressed with cdc42 and acts cooperatively to control the epidermal lineage development by affecting cell death. Our results uncover an important role of MRLC, as an inhibitor of apoptosis, involves in epidermal development." @default.
- W4382011134 created "2023-06-27" @default.
- W4382011134 creator A5011822382 @default.
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- W4382011134 date "2023-06-25" @default.
- W4382011134 modified "2023-09-25" @default.
- W4382011134 title "<scp><i>MRLC</i></scp> controls apoptotic cell death and functions to regulate epidermal development during planarian regeneration and homeostasis" @default.
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- W4382011134 doi "https://doi.org/10.1111/cpr.13524" @default.
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- W4382011134 hasPublicationYear "2023" @default.
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