FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4382011336> ?p ?o ?g. }

• W4382011336 endingPage "985" @default.
• W4382011336 startingPage "968" @default.
• W4382011336 abstract "Abstract Background and Objectives Periodontitis, a prevalent chronic inflammatory condition, poses a significant risk of tooth loosening and subsequent tooth loss. Within the realm of programmed cell death, a recently recognized process known as necroptosis has garnered attention for its involvement in numerous inflammatory diseases. Nevertheless, its correlation with periodontitis is indistinct. Our study aimed to identify necroptosis‐related lncRNAs and crucial lncRNA‐miRNA‐mRNA regulatory axes in periodontitis to further understand the pathogenesis of periodontitis. Materials and Methods Gene expression profiles in gingival tissues were acquired from the Gene Expression Omnibus (GEO) database. Selecting hub necroptosis‐related lncRNA and extracting the key lncRNA‐miRNA‐mRNA axes based on the ceRNA network by adding novel machine‐learning models based on conventional analysis and combining qRT‐PCR validation. Then, an artificial neural network (ANN) model was constructed for lncRNA in regulatory axes, and the accuracy of the model was validated by receiver operating characteristic (ROC) curve analysis. The clinical effect of the model was evaluated by decision curve analysis (DCA). Weighted correlation network analysis (WGCNA) and single‐sample gene set enrichment analysis (ssGSEA) was performed to explore how these lncRNAs work in periodontitis. Results Seven hub necroptosis‐related lncRNAs and three lncRNA‐miRNA‐mRNA regulatory axes (RP11‐138A9.1/hsa‐miR‐98‐5p/ZBP1 axis, RP11‐96D1.11/hsa‐miR‐185‐5p/EZH2 axis, and RP4‐773 N10.4/hsa‐miR‐21‐5p/TLR3 axis) were predicted. WGCNA revealed that RP11‐138A9.1 was significantly correlated with the “purple module”. Functional enrichment analysis and ssGSEA demonstrated that the RP11‐138A9.1/hsa‐miR‐98‐5p/ZBP1 axis is closely related to the inflammation and immune processes in periodontitis. Conclusion Our study predicted a crucial necroptosis‐related regulatory axis (RP11‐138A9.1/hsa‐miR‐98‐5p/ZBP1) based on the ceRNA network, which may aid in elucidating the role and mechanism of necroptosis in periodontitis." @default.
• W4382011336 created "2023-06-27" @default.
• W4382011336 creator A5010174180 @default.
• W4382011336 creator A5016496688 @default.
• W4382011336 creator A5035604684 @default.
• W4382011336 creator A5046206386 @default.
• W4382011336 creator A5078644299 @default.
• W4382011336 date "2023-06-26" @default.
• W4382011336 modified "2023-09-27" @default.
• W4382011336 title "Revealing a potential necroptosis‐related axis (RP11‐138A9.1/hsa‐miR‐98‐5p/ZBP1) in periodontitis by construction of the ceRNA network" @default.
• W4382011336 cites W1958065935 @default.
• W4382011336 cites W1966977448 @default.
• W4382011336 cites W1972784467 @default.
• W4382011336 cites W1983626608 @default.
• W4382011336 cites W1990974422 @default.
• W4382011336 cites W2021838232 @default.
• W4382011336 cites W2033968700 @default.
• W4382011336 cites W2045030989 @default.
• W4382011336 cites W2046387002 @default.
• W4382011336 cites W2051026238 @default.
• W4382011336 cites W2077317536 @default.
• W4382011336 cites W2078553040 @default.
• W4382011336 cites W2087232320 @default.
• W4382011336 cites W2090543816 @default.
• W4382011336 cites W2091363184 @default.
• W4382011336 cites W2142480686 @default.
• W4382011336 cites W2144722732 @default.
• W4382011336 cites W2146739467 @default.
• W4382011336 cites W2159707944 @default.
• W4382011336 cites W2161074777 @default.
• W4382011336 cites W2547911415 @default.
• W4382011336 cites W2610021903 @default.
• W4382011336 cites W2741223751 @default.
• W4382011336 cites W2741274618 @default.
• W4382011336 cites W2789926271 @default.
• W4382011336 cites W2809048536 @default.
• W4382011336 cites W2886522935 @default.
• W4382011336 cites W2888114389 @default.
• W4382011336 cites W2893914219 @default.
• W4382011336 cites W2911922390 @default.
• W4382011336 cites W2918308219 @default.
• W4382011336 cites W2949273159 @default.
• W4382011336 cites W2949864406 @default.
• W4382011336 cites W2950266491 @default.
• W4382011336 cites W2973075799 @default.
• W4382011336 cites W2975919851 @default.
• W4382011336 cites W2983652778 @default.
• W4382011336 cites W2996628744 @default.
• W4382011336 cites W3010018464 @default.
• W4382011336 cites W3013796529 @default.
• W4382011336 cites W3016824803 @default.
• W4382011336 cites W3029341961 @default.
• W4382011336 cites W3062744587 @default.
• W4382011336 cites W3081504108 @default.
• W4382011336 cites W3082317940 @default.
• W4382011336 cites W3107691017 @default.
• W4382011336 cites W3133204674 @default.
• W4382011336 cites W3144674846 @default.
• W4382011336 cites W3160374037 @default.
• W4382011336 cites W3166110253 @default.
• W4382011336 cites W3195851235 @default.
• W4382011336 cites W3198527956 @default.
• W4382011336 cites W4211223324 @default.
• W4382011336 cites W4214700578 @default.
• W4382011336 cites W4237844339 @default.
• W4382011336 cites W4281481679 @default.
• W4382011336 cites W4281972476 @default.
• W4382011336 cites W4283157384 @default.
• W4382011336 cites W4283718992 @default.
• W4382011336 cites W4284694966 @default.
• W4382011336 cites W4285493052 @default.
• W4382011336 cites W4295015652 @default.
• W4382011336 cites W4312076951 @default.
• W4382011336 doi "https://doi.org/10.1111/jre.13157" @default.
• W4382011336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37357608" @default.
• W4382011336 hasPublicationYear "2023" @default.
• W4382011336 type Work @default.
• W4382011336 citedByCount "0" @default.
• W4382011336 crossrefType "journal-article" @default.
• W4382011336 hasAuthorship W4382011336A5010174180 @default.
• W4382011336 hasAuthorship W4382011336A5016496688 @default.
• W4382011336 hasAuthorship W4382011336A5035604684 @default.
• W4382011336 hasAuthorship W4382011336A5046206386 @default.
• W4382011336 hasAuthorship W4382011336A5078644299 @default.
• W4382011336 hasConcept C104317684 @default.
• W4382011336 hasConcept C119857082 @default.
• W4382011336 hasConcept C126322002 @default.
• W4382011336 hasConcept C127561419 @default.
• W4382011336 hasConcept C145059251 @default.
• W4382011336 hasConcept C150194340 @default.
• W4382011336 hasConcept C190283241 @default.
• W4382011336 hasConcept C2780385504 @default.
• W4382011336 hasConcept C31573885 @default.
• W4382011336 hasConcept C41008148 @default.
• W4382011336 hasConcept C54355233 @default.
• W4382011336 hasConcept C58471807 @default.
• W4382011336 hasConcept C60365752 @default.
• W4382011336 hasConcept C60644358 @default.

• next